Olink Explorer >5400
Closed Solicitation Posted
- Solicitation number
- 75N98026Q00800
- Agency
-
Office of Logisitics and Acquisition Operations
National Institutes of Health, Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 541380 Testing Laboratories and Services
- PSC
- Q301 Reference Laboratory Testing
- Place of performance
- Bethesda, Maryland 20892, United States
- Points of contact
Notice details come from SAM.gov. Updated .
About this opportunity
The Department of Health and Human Services National Institutes of Health Office of Logistics and Acquisition Operations seeks procurement of an Olink Explorer >5400 proteomics platform, with proposals due July 25, 2026. No set-aside applies.
Place of performance is Bethesda, Maryland. The requirement specifies the Olink Explorer >5400 platform to measure approximately 5,400 or more human proteins simultaneously in a single workflow using Proximity Extension Assay technology with dual antibody recognition coupled to DNA barcoding and next-generation sequencing readout. The platform must require only 2 microliters of plasma, serum, or other sample types as input; deliver reported 99.5% specificity with negligible cross-reactivity; and provide approximately 10 orders of magnitude dynamic range (fg/mL to mg/mL) to detect both low- and high-abundance proteins. The platform will support laboratory research on the role of inflammation, innate resistance, and commensal microbiota in carcinogenesis, cancer progression, and cancer therapy. Key capabilities include broad proteome coverage with antibody-based specificity, excellent sensitivity for low-abundance circulating proteins such as cytokines and signaling proteins, and standardization suitable for epidemiology and multi-omics studies. The NAICS code is 541380, Testing Laboratories and Services; the PSC code is Q301, Reference Laboratory Testing.
Notice text
Requirements:
2.0 BACKGROUND
Our lab studies the role of inflammation/innate resistance and commensal microbiota in carcinogenesis, cancer progression and therapy of cancer.
The following product features/characteristics are required for this requirement:
Protein Coverage - Measures ~5,400+ human proteins simultaneously in a single workflow.
Technology - Uses Proximity Extension Assay (PEA) with dual antibody recognition coupled to DNA barcoding and next-generation sequencing (NGS) readout.
Sample input – requires only 2 ul of plasma, serum, and other sample types
Specificity - Reported 99.5% specificity with negligible cross-reactivity due to dual-recognition antibody design.
Dynamic Range - Approximately 10 orders of magnitude (fg/mL to mg/mL), enabling detection of both low- and high-abundance proteins.
Key strengths
- Very broad proteome coverage while maintaining antibody-based specificity.
- Excellent sensitivity for low-abundance circulating proteins (especially cytokines and signaling proteins).
- Extremely low sample-volume requirement.
- Highly standardized platform, making it attractive for epidemiology and multi-omics studies.
Files
| File | Type | Posted |
|---|---|---|
| Requirement 7.docx | DOCX document |
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