Miniature two-photon microscope system for mice

The National Institute on Drug Abuse (NIDA), part of the Department of Health and Human Services, has issued a Sources Sought Notice seeking vendors capable of providing a miniature two-photon microscope system for mice research. The required system must be lightweight and compact, weighing approximately 2.5 grams and measuring 20 x 10 x 30 millimeters, with the capability to record calcium-indicator activities of single neurons while mice are unrestrained and performing tasks. The system should preferably be compatible with the laboratory's existing Spectra-Physics Mai Tai HP laser and include installation and maintenance services. Interested companies must submit a five-page capability statement that addresses each project requirement, includes their total number of employees, any relevant GSA Schedule or government-wide acquisition contracts, and provides contact information. The response deadline is July 7, 2025, with submissions required electronically to Polina Klimenkova at polina.klimenkova@nih.gov.

This procurement opportunity does not utilize any federal contracting set-aside designations, making it open to all qualified vendors. No incumbent contractors or potential award values are specified in the notice, as this represents a market research effort rather than a formal solicitation for proposals. The anticipated delivery timeline requires the system to be delivered within three months of order placement. The government has expressed a preference for an extended warranty covering maintenance services beyond the standard delivery period. The opportunity falls under NAICS code 334516 for Analytical Laboratory Instrument Manufacturing and PSC code 6640 for Laboratory Equipment and Supplies, indicating the specialized nature of the required scientific instrumentation.