Material Generation and Molecular Evaluation of 3 Antibodies R&D Services RFQ

The Department of Veterans Affairs Veterans Health Administration Veterans Integrated Service Network 20 is seeking a contractor to perform material generation and molecular evaluation of three human monoclonal antibodies with therapeutic potential through Request for Quote 36C26025Q0592. The scope of work includes comprehensive in silico developability assessment, biophysical profiling, and multi-attributed method analysis, encompassing tasks such as sequence evaluation, structure modeling, immunogenicity assessment, material generation via HEK293 cell transient transfection, protein A purification, and extensive analytical characterization including conformational and colloidal stability testing. The contract requires the contractor to deliver a sequence-level report, sufficient material for subsequent analyses, and an assessment analytical data package. Evaluation criteria will consider technical capability, past performance, and price, with technical and past performance weighted more heavily than price. The solicitation deadline has been extended multiple times, with the current response deadline set for July 23, 2025, at 3:00 PM PDT.

This solicitation does not utilize any set-aside designations and is classified under NAICS code 541714 (Research and Development in Biotechnology) with a size standard of 1000 employees for small business qualification. No current contractors or incumbents are identified in the documentation. The contract includes four Contract Line Items (CLINs) covering material generation, in silico analysis, biophysical characterization, and DNA synthesis, with optional CLINs 0001 and 0004 that may or may not be exercised depending on budget availability. The period of performance is six months, with work to be conducted at the contractor's facility and no on-site VA access required. The place of performance is associated with the Boise VA Medical Center in Idaho, with delivery of materials to the Portland VA Medical Center, while the contracting office operates from Vancouver, Washington.