HUBBLE Industry Day

The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office is hosting an Industry Day on September 25, 2026, from 12:00 PM to 5:00 PM at the SPA Arlington Research Collaboration Center in Arlington, Virginia, in support of the planned "High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators" (HUBBLE) program. Advance registration closes September 18, 2026, at 4:00 PM ET; a hybrid option is available for remote attendance, but all presenters must attend in person.

The HUBBLE program seeks to develop an in-silico capability for mapping protein-protein interactions (PPIs) to identify novel diagnostic and therapeutic targets. The program will generate a comprehensive human interactome representing both healthy and disrupted physiologies, using low-dimensional signatures of binding landscapes to overcome experimental time and resource constraints. By program end, HUBBLE will deliver a hypercatalog of context-aware interactions with predicted probabilities, affinities, and kinetics specific to cell types and conditions, with application to complex physiological states such as traumatic brain injury.

Interested parties may submit lightning talk presentations (one Adobe PDF slide deck per attendee) by September 21, 2026, at 4:00 PM ET to HUBBLE@darpa.mil on a first-come, first-served basis. Organizations may also submit one-page teaming profiles in MS Word or Adobe PDF format by September 21, 2026, describing technical competencies, facilities, and desired partner competencies; profiles will be distributed to all registered attendees by September 28, 2026. Non-U.S. citizens must submit a DARPA Form 60 or Official Visit Request by September 18, 2026. Attendance is not required for proposal submission or funding selection. This Special Notice is informational only and does not constitute a formal solicitation.