Final Innovative Solutions Opening (ISO) ARPA-H Rare Disease AI/ML for Precision Integrated Diagnostics (RAPID)
Closed Solicitation Posted
- Solicitation number
- ARPA-H-SOL-25-119
- Agency
- National Institutes of Health Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Place of performance
- United States
- Points of contact
-
- RAPID Email Box rapid@arpa-h.gov
Notice details come from SAM.gov. Updated .
About this opportunity
The Department of Health and Human Services National Institutes of Health is seeking innovative solutions for the Rare Disease AI/ML for Precision Integrated Diagnostics (RAPID) program, aimed at developing advanced diagnostic support tools to reduce diagnostic delays for rare disease patients worldwide. The solicitation covers three technical areas: aggregating longitudinal rare disease patient data, collecting novel multimodal patient data, and establishing a Rare Disease Data Commons for AI model development. Proposers must submit solution summaries by February 14, 2025, with full proposals due April 11, 2025, and a Proposers' Day scheduled for January 23, 2025. Evaluation will focus on the ability to systematically identify and diagnose rare diseases more efficiently and accurately, with an emphasis on developing population-scale diagnostic tools. Key submission deadlines include questions due by February 4, 2025, with the full program designed to run 4.5 years across two phases.
The solicitation is not set aside for any specific business type, encouraging participation from universities, non-profits, and small businesses, though FFRDCs and government entities are restricted from prime or sub-performer roles. The program targets aggregating data from at least 2,700 rare diseases and 80,550 patient samples by its conclusion, with awards to be made through Other Transaction Agreements. Performance will be conducted across the United States, with cost sharing possible but not required. The program will involve a 21-month base period followed by a 33-month option period, creating a comprehensive approach to rare disease diagnostics. While specific award values are not publicly disclosed, the solicitation indicates multiple awards are anticipated, with performers expected to collaborate and share data across the RAPID program's technical areas.
Notice text
6 versions
Update #6 · Latest ·
20 MAR: Note: It is permissible to join as many proposals as you would like within each RAPID program TA or across TAs. While there is statutory language that may suggest ARPA-H is limited in the number of awards it may make to one entity, there are circumstances in which ARPA-H may make more than three awards to a particular person or organization. ARPA-H encourages organizations to submit their research ideas notwithstanding this perceived limitation.This guidance supersedes the limitation noted in an earlier version of the FAQs published on the RAPID program webpage and in the Proposers' Day video. Both resources have been updated accordingly.
14 MAR: The deadline for proposals to the RAPID program (ARPA-H-SOL-25-119) is extended to April 24, 2025 05:00 pm EDT. Feedback on Solution Summaries is expected to be sent out the week of March 17-21, 2025.
Amendment 1 changes:
-The full proposal due date was extended to April 24, 2025
-All times were updated from EST to EDT
Visit the RAPID Program Page for additional materials and program updates.
21 FEB: The RAPID Patients’ Day (ARPA-H-SN-25-127) event is now CANCELLED. The RAPID team will post a video and other information when possible. Questions sent to RAPID@arpa-h.gov will be answered as soon as the RAPID team is able to respond.
23 JAN: Due to circumstances outside of ARPA-H’s control, the RAPID Proposers’ Day event is now CANCELLED. Questions sent to RAPID@arpa-h.gov ARE UNABLE TO BE ANSWERED AT THIS TIME.
22 JAN: RAPID proposers intending to participate in the RAPID Proposers' Day are encouraged to review ARPA-H Special Notice ARPA-H-SN-25-124. Due to circumstances outside of ARPA-H’s control, the RAPID Proposers’ Day event will now occur only virtually. Verified/accepted participants are encouraged to verify they have received the Zoom link/invitation. Questions sent to RAPID@arpa-h.gov will be addressed as quickly as possible.
The is the final ISO for the RAPID program. RAPID aims to end or significantly reduce the prolonged diagnostic odysseys affecting millions of rare disease patients worldwide. RAPID seeks to develop novel diagnostic support tools for population-scale rare disease detection, systematically identifying and diagnosing rare disease patients more efficiently and accurately.
Update #5 ·
14 MAR: The deadline for proposals to the RAPID program (ARPA-H-SOL-25-119) is extended to April 24, 2025 05:00 pm EDT. Feedback on Solution Summaries is expected to be sent out the week of March 17-21, 2025.
Amendment 1 changes:
-The full proposal due date was extended to April 24, 2025
-All times were updated from EST to EDT
Visit the RAPID Program Page for additional materials and program updates.
21 FEB: The RAPID Patients’ Day (ARPA-H-SN-25-127) event is now CANCELLED. The RAPID team will post a video and other information when possible. Questions sent to RAPID@arpa-h.gov will be answered as soon as the RAPID team is able to respond.
23 JAN: Due to circumstances outside of ARPA-H’s control, the RAPID Proposers’ Day event is now CANCELLED. Questions sent to RAPID@arpa-h.gov ARE UNABLE TO BE ANSWERED AT THIS TIME.
22 JAN: RAPID proposers intending to participate in the RAPID Proposers' Day are encouraged to review ARPA-H Special Notice ARPA-H-SN-25-124. Due to circumstances outside of ARPA-H’s control, the RAPID Proposers’ Day event will now occur only virtually. Verified/accepted participants are encouraged to verify they have received the Zoom link/invitation. Questions sent to RAPID@arpa-h.gov will be addressed as quickly as possible.
The is the final ISO for the RAPID program. RAPID aims to end or significantly reduce the prolonged diagnostic odysseys affecting millions of rare disease patients worldwide. RAPID seeks to develop novel diagnostic support tools for population-scale rare disease detection, systematically identifying and diagnosing rare disease patients more efficiently and accurately.
Update #4 ·
21 FEB: The RAPID Patients’ Day (ARPA-H-SN-25-127) event is now CANCELLED. The RAPID team will post a video and other information when possible. Questions sent to RAPID@arpa-h.gov will be answered as soon as the RAPID team is able to respond.
23 JAN: Due to circumstances outside of ARPA-H’s control, the RAPID Proposers’ Day event is now CANCELLED. Questions sent to RAPID@arpa-h.gov ARE UNABLE TO BE ANSWERED AT THIS TIME.
22 JAN: RAPID proposers intending to participate in the RAPID Proposers' Day are encouraged to review ARPA-H Special Notice ARPA-H-SN-25-124. Due to circumstances outside of ARPA-H’s control, the RAPID Proposers’ Day event will now occur only virtually. Verified/accepted participants are encouraged to verify they have received the Zoom link/invitation. Questions sent to RAPID@arpa-h.gov will be addressed as quickly as possible.
The is the final ISO for the RAPID program. RAPID aims to end or significantly reduce the prolonged diagnostic odysseys affecting millions of rare disease patients worldwide. RAPID seeks to develop novel diagnostic support tools for population-scale rare disease detection, systematically identifying and diagnosing rare disease patients more efficiently and accurately.
Update #3 ·
23 JAN: Due to circumstances outside of ARPA-H’s control, the RAPID Proposers’ Day event is now CANCELLED. Questions sent to RAPID@arpa-h.gov ARE UNABLE TO BE ANSWERED AT THIS TIME.
22 JAN: RAPID proposers intending to participate in the RAPID Proposers' Day are encouraged to review ARPA-H Special Notice ARPA-H-SN-25-124. Due to circumstances outside of ARPA-H’s control, the RAPID Proposers’ Day event will now occur only virtually. Verified/accepted participants are encouraged to verify they have received the Zoom link/invitation. Questions sent to RAPID@arpa-h.gov will be addressed as quickly as possible.
The is the final ISO for the RAPID program. RAPID aims to end or significantly reduce the prolonged diagnostic odysseys affecting millions of rare disease patients worldwide. RAPID seeks to develop novel diagnostic support tools for population-scale rare disease detection, systematically identifying and diagnosing rare disease patients more efficiently and accurately.
Update #2 ·
22 JAN: RAPID proposers intending to participate in the RAPID Proposers' Day are encouraged to review ARPA-H Special Notice ARPA-H-SN-25-124. Due to circumstances outside of ARPA-H’s control, the RAPID Proposers’ Day event will now occur only virtually. Verified/accepted participants are encouraged to verify they have received the Zoom link/invitation. Questions sent to RAPID@arpa-h.gov will be addressed as quickly as possible.
The is the final ISO for the RAPID program. RAPID aims to end or significantly reduce the prolonged diagnostic odysseys affecting millions of rare disease patients worldwide. RAPID seeks to develop novel diagnostic support tools for population-scale rare disease detection, systematically identifying and diagnosing rare disease patients more efficiently and accurately.
Update #1 ·
The is the final ISO for the RAPID program. RAPID aims to end or significantly reduce the prolonged diagnostic odysseys affecting millions of rare disease patients worldwide. RAPID seeks to develop novel diagnostic support tools for population-scale rare disease detection, systematically identifying and diagnosing rare disease patients more efficiently and accurately.
Attachments
| File | Type | Posted |
|---|---|---|
| RAPID_SOL_25_119_FINAL Amendment 1 March 14 2025.pdf | ||
| RAPID Rare Disease Prioritization TEMPLATE.xlsx | XLSX spreadsheet | |
| RAPID Cost Proposal Spreadsheet TEMPLATE.xlsx | XLSX spreadsheet | |
| RAPID_SOL_25_119_FINAL.pdf | ||
| RAPID Statement of Work TEMPLATE.docx | DOCX document |
Notice history
| Notice | Type | Posted |
|---|---|---|
| Final Innovative Solutions Opening (ISO) ARPA-H Rare Disease AI/ML for Precision Integrated Diagnostics (RAPID) | Solicitation | |
| ARPA-H Rare Disease AI/ML and Precision Integrated Diagnostics (RAPID) Patients’ Day | Special Notice | |
| DRAFT Innovative Solutions Opening (ISO) ARPA-H Rare disease AI/ML for Precision Integrated Diagnostics (RAPID) | Pre-Solicitation | |
| CANCELLED_ARPA-H Rare disease AI/ML for Precision Integrated Diagnostics (RAPID) Proposers' Day | Special Notice |
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