VT - Attachment B - Additional Instructions.pdf
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- Venous Thrombosis (VT)
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- 80JSC026Q0014
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This document is Attachment B of a Request for Quotation (RFQ) for Venus Thrombosis research, issued by NASA dated September 24, 2026. The RFQ solicits quotes addressing one or more areas: development and validation of approaches to surveil, reduce risk of, and prevent or treat venous thrombosis (VT) during spaceflight and exploration missions; point-of-care assessment devices capable of functioning in weightlessness or reduced gravity; mechanical countermeasures to prevent or treat VT; and future spaceflight or spaceflight analog research relevant to VT. Prospective research and retrospective analysis are both acceptable, including novel approaches to analyze existing astronaut imaging datasets (2-D ultrasound, Doppler ultrasound, and MRI) and measurement of biomarkers in stored frozen samples (blood, saliva, and/or urine). Respondents must provide applicable qualifications and certifications for team members and facilities/equipment, and schedules and budgets must be realistic and include stated assumptions, accounting for NASA's inability to guarantee manifesting on commercial providers.
Responses must comply with the Human Exploration Research Opportunities (HERO) Notice of Funding Opportunities (NOFO) framework with modifications, including implementation of Dual-Anonymous Peer Review (DAPR) guidelines whereby information non-compliant with DAPR guidelines will be redacted prior to technical review. An NSPIRES cover page is not required, and all attributable information must be segregated into a separate non-anonymized section from the anonymized quote. Specific page limits apply: the anonymized portion includes Table of Contents (as needed), Map to Human Research Roadmap (2 pages), Project Description (10 pages), Statistical Approach (1 page), Management Approach (as needed), Data Management Plan (2 pages), and Budget with Narrative and Details (as needed); the non-anonymized portion includes Table of Contents (as needed), List of Team Members and Organizations (as needed), Team Expertise (1 page), Biographical Sketches/Curriculum Vitae (2 pages preferred), Current and Pending Support (as needed), Bibliography of Current and Past HRP Funded Projects (as needed), Statements of Commitment and Letters of Support (as needed), Assurance of Compliance if applicable (as needed), Facilities and Equipment (as needed), Flight Experiment Resource Worksheet (as needed), and Retrospective Data Request Study Feasibility Assessment Form (as needed).
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Venus Thrombosis Attachment B – Additional Submission Instructions 9/24/2026
Additional Submission Instructions
Appropriate responses to this RFQ shall address one or more of the following:
1. Quotes for the development and validation of approach(es) to surveil, reduce risk of, and/or prevent/treat (either prophylactic or treatment countermeasures) VT during spaceflight and exploration missions, including rationale and methodology. This could include:
a. Provision of a point-of-care assessment device capable of functioning in weightlessness or reduced gravity, the development of novel technologies to assess VT risk (e.g., venous flow dynamics, biomarkers) etc.
b. Countermeasures, specifically mechanical countermeasures, to prevent or treat VT during spaceflight and exploration missions.
c. Quotes for future spaceflight and/or spaceflight analog research relevant to VT during spaceflight and exploration missions. Relevant applications might include short- and long-duration missions in low-Earth orbit, missions beyond low-Earth orbit, and habitation in partial gravity environments. Ground-based research may include investigations in relevant patient populations or parabolic flight.
2. Quotes may include prospective research and/or retrospective analysis. Retrospective analysis may include:
a. Novel approaches to analyze existing astronaut imaging datasets (i.e., 2-D ultrasound, Doppler ultrasound, and magnetic resonance imaging (MRI))
b. Measurement of biomarkers in stored frozen samples (i.e., blood, saliva and/or urine)
3. Schedule must be reflective of the type of quote submitted (e.g., spaceflight project, patient populations, etc.). Given the RFQ mechanism allows for varying schedule and budget submissions, budget and schedule assumptions must be included in all responses. NASA cannot guarantee manifesting on commercial providers, this should be taken into account in generating schedule and budget assumptions.
4. Provide applicable qualifications/certifications for team members and/or facility/equipment.
5. Human Exploration Research Opportunities (HERO) Notice of Funding Opportunities (NOFO) Resources shall be used as necessary by proposers with the following modifications:
a. Dual-Anonymous Peer Review (DAPR);
https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=10 31521/solicitationId=%7B0FCFE162-702B-B48A-F815- 7D6E4C6C85E7%7D/viewSolicitationDocument=1/2025%20HERO%20- %20DAPR%20Guidelines.pdf NOTE: Information not compliant with the DAPR guidelines will be subject to redaction prior to the Technical Acceptability review.
i. An NSPIRES cover page is not required.
ii. All attributable information must be included in a separate section from the quote (i.e., team identities/expertise, CV/biosketches, letters of resource support, assurances of compliance, facilities and equipment special forms https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031521/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/2025%20HERO%20-%20DAPR%20Guidelines.pdf https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031521/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/2025%20HERO%20-%20DAPR%20Guidelines.pdf https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031521/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/2025%20HERO%20-%20DAPR%20Guidelines.pdf https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031521/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/2025%20HERO%20-%20DAPR%20Guidelines.pdf
Venus Thrombosis Attachment B – Additional Submission Instructions 9/24/2026 or worksheets [Flight Experiment Resource Worksheet, Retrospective Data Request Feasibility Assessment Form]).
b. Flight Experiment Resource Worksheet;
https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=10 31516/solicitationId=%7B0FCFE162-702B-B48A-F815- 7D6E4C6C85E7%7D/viewSolicitationDocument=1/HRP%20Flight%20Experiment% 20Information%20Package_April2024_final.pdf
c. Retrospective Data Request Feasibility Assessment Form;
https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=10 31518/solicitationId=%7B0FCFE162-702B-B48A-F815- 7D6E4C6C85E7%7D/viewSolicitationDocument=1/2020+HRP+Retrospective+Data +Request+Guidelines_LSDA-LSAH.pdf
d. Statistical Approach details may be found at:
https://nspires.nasaprs.com/external/viewrepositorydocument?cmdocumentid=10 31509&solicitationId={0FCFE162-702B-B48A-F815- 7D6E4C6C85E7}&viewSolicitationDocument=1
e. Data Management Plan details may be found at:
https://nspires.nasaprs.com/external/viewrepositorydocument?cmdocumentid=10 31524&solicitationId={0FCFE162-702B-B48A-F815- 7D6E4C6C85E7}&viewSolicitationDocument=1
f. Quote Page Limits, all are required:
i. Anonymized Portion:
Section Page Limit Table of Contents As Needed Map to Human Research Roadmap 2 Project Description 10 Statistical Approach 1 Management Approach As Needed Data Management Plan 2 Budget with Budget Narrative and Budget Details As Needed
ii. Non-anonymized Portion:
Section Page Limit Table of Contents As Needed List of Team Members and Organizations As Needed Team Expertise 1 Biographical Sketches/Curriculum Vitae 2 pages preferred Current and Pending Support As Needed Bibliography of Current and Past HRP Funded Projects As Needed Statements of Commitment and Letters of Support, Feasibility, Endorsement
As Needed
Assurance of Compliance (if involving human subjects testing) As Needed Facilities and Equipment As Needed Flight Experiment Resource Worksheet As Needed Retrospective Data Request Study Feasibility Assessment Form As Needed https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031516/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/HRP%20Flight%20Experiment%20Information%20Package_April2024_final.pdf https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031516/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/HRP%20Flight%20Experiment%20Information%20Package_April2024_final.pdf https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031516/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/HRP%20Flight%20Experiment%20Information%20Package_April2024_final.pdf https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031516/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/HRP%20Flight%20Experiment%20Information%20Package_April2024_final.pdf https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031518/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/2020+HRP+Retrospective+Data+Request+Guidelines_LSDA-LSAH.pdf https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031518/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/2020+HRP+Retrospective+Data+Request+Guidelines_LSDA-LSAH.pdf https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031518/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/2020+HRP+Retrospective+Data+Request+Guidelines_LSDA-LSAH.pdf https://nspires.nasaprs.com/external/viewrepositorydocument/cmdocumentid=1031518/solicitationId=%7B0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7D/viewSolicitationDocument=1/2020+HRP+Retrospective+Data+Request+Guidelines_LSDA-LSAH.pdf https://nspires.nasaprs.com/external/viewrepositorydocument?cmdocumentid=1031509&solicitationId=%7b0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7d&viewSolicitationDocument=1 https://nspires.nasaprs.com/external/viewrepositorydocument?cmdocumentid=1031509&solicitationId=%7b0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7d&viewSolicitationDocument=1 https://nspires.nasaprs.com/external/viewrepositorydocument?cmdocumentid=1031509&solicitationId=%7b0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7d&viewSolicitationDocument=1 https://nspires.nasaprs.com/external/viewrepositorydocument?cmdocumentid=1031524&solicitationId=%7b0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7d&viewSolicitationDocument=1 https://nspires.nasaprs.com/external/viewrepositorydocument?cmdocumentid=1031524&solicitationId=%7b0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7d&viewSolicitationDocument=1 https://nspires.nasaprs.com/external/viewrepositorydocument?cmdocumentid=1031524&solicitationId=%7b0FCFE162-702B-B48A-F815-7D6E4C6C85E7%7d&viewSolicitationDocument=1
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