Sol_75N98027Q00027.pdf

REQUEST FOR QUOTATION

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10 Center Dr Bldg 10 Rm 3E-5216

National Institutes of Health OD - Office of Logistics and Acquisition Operations 6100 Executive Blvd., Room 6B05 Bethesda, MD 20892-7511

75N98027Q00027

NICHOLAS CAPOBIANCO

+10

000-000000

NIH/NHLBI

20892

10/22/2026

11/02/2026 0900 ES

Multiple

Bethesda

MD

The purpose of this NON-COMPETITIVE

COMBINED SYNOPSIS / SOLICITATION is to provide NHLBI with DNA Sequencing of

Bone Marrow Failure Syndromes.

The following FAR clauses and Provisions are applicable to this award.

FAR 52.204-13 System for Award

Management Maintenance (Oct 2018);

FAR 52.204-18 Commercial and Government

Entity Code Maintenance (Aug 2020);

HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity

Investigations (Dec 2015).

FAR 52.212-4 Contract Terms and

Continued...

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OPTIONAL FORM 336 (4-86)

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NSN 7540-01-152-8067

75N98027Q00027

Conditions -In addition to all the applicable commercial Products and Commercial Services

(Nov 2023)

FAR 52.252-2 CLAUSES INCORPORATED BY REFERENCE

To avoid delay in payment, all invoices must be uploaded into the invoicing processing platform

(IPP) (https://www.ipp.gov). The invoice must match the line item description on the purchase order. It must also state that payment is to be made using a three-way match.

NON-COMPETITIVE COMBINED SYNOPSIS / SOLICITATION

Title: DNA Sequencing of Bone Marrow Failure Syndromes (ArcherDX VariantPlex NGS Library Preparation Kits)

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued.

(ii) The solicitation number is 75N98027Q00027. This solicitation is issued as a Notice of Intent (NOI) for a non-competitive combined synopsis/solicitation to award a contract or purchase order without providing for full and open competition (including brand-name, if applicable).

This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold. Additional authority includes 41 U.S.C. 1901 and FAR 6.302-3(a)(2)(ii).

The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, intends to negotiate and award a firm-fixed-price purchase order on a non-competitive basis to Integrated DNA Technologies, Inc. (IDT), 1710 Commercial Park, Coralville, IA 52241, for custom-designed ArcherDX VariantPlex Next-Generation Sequencing (NGS) target-enrichment library preparation kits. Integrated DNA Technologies, Inc. is the sole owner, manufacturer, and distributor of the proprietary ArcherDX VariantPlex Anchored Multiplex PCR (AMP) chemistry, which has been utilized by the NHLBI Hematology Branch since 2019 to perform error-correcting sequencing (ECS) and is required to maintain scientific continuity, prevent technical batch effects across longitudinal patient cohorts, and ensure compatibility with the laboratory’s established Archer Analysis bioinformatics pipeline. All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.

(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2026-01, effective 03/13/2026.

(iv) The associated NAICS code is 325413 (In-Vitro Diagnostic Substance Manufacturing) and the small business size standard is 1,250 employees. This requirement is not set aside for small business.

(v) Description of Requirement:

The National Heart, Lung, and Blood Institute (NHLBI), Hematology Branch, Hematopoiesis and Bone Marrow Failure Laboratory requires custom-designed ArcherDX VariantPlex Next-Generation Sequencing (NGS) target-enrichment library preparation kits to screen more than 200 patient samples with aplastic anemia and bone marrow failure syndromes (BMF) for low-frequency somatic mutations (single nucleotide variations and indels below 2–4% variant allele frequency).

Salient Characteristics / Technical Requirements:

• Must utilize proprietary ArcherDX VariantPlex Anchored Multiplex PCR (AMP) target-enrichment chemistry to generate high-complexity NGS libraries from low-input DNA.

• Must incorporate pre-amplification ligation of unique molecular barcodes (MBCs) to enable unique molecule counting and error-correcting sequencing (ECS) for accurate distinction of true low-frequency variants from intrinsic NGS sequencing errors.

• Must be custom-configured to target the laboratory’s specific panel of bone marrow failure (BMF) and clonal hematopoiesis genes.

• Must be fully compatible with 150 bp paired-end sequencing on Illumina NovaSeq instruments and directly compatible with the laboratory’s existing Archer Analysis bioinformatics software pipeline established in 2019.

• Estimated Delivery Turnaround Time: 4–6 weeks after receipt of order (ARO).

(vi) Delivery Location:

National Institutes of Health (NIH) / NHLBI Hematopoiesis and Bone Marrow Failure Laboratory, Hematology Branch Attn: Fernanda Gutierrez Rodrigues, PharmD, PhD Building 10, Room 3E-5216 10 Center Drive Bethesda, MD 20892

(vii) [Reserved]

(viii) FAR 52.204-7, System for Award Management, applies to this acquisition.

(ix) The provision at FAR 52.212-1, Instructions to Offerors—Commercial Items, applies to this acquisition.

(x) The provision at FAR 52.212-2, Evaluation—Commercial Items, applies to this acquisition.

(a) A written notice of award or acceptance of an offer, issued to the successful offeror within the time specified in the offer, shall result in a binding contract without further action by either party. The Government reserves the right to accept any offer (or part of an offer) before the expiration date, whether or not discussions are conducted, unless a written notice of withdrawal is received prior to award.

(xi) FAR 52.212-4, Contract Terms and Conditions—Commercial Items, applies to this acquisition.

(xii) Additional contract requirements or terms and conditions, as determined necessary by the Contracting Officer and consistent with customary commercial practices: None.

(xiii) The Defense Priorities and Allocations System (DPAS) is not applicable to this requirement.

(xiv) Submission Requirements:

Responses must include sufficient information to demonstrate the respondent’s capability to provide the required product or service.

Price quotations shall include, at a minimum: unit price, list price, shipping and handling costs, delivery timeframe after award, delivery terms, prompt payment discount terms, F.O.B. point (destination or origin), product or catalog numbers, product descriptions, and any other relevant information.

Evaluation factors may include, but are not limited to: past performance, technical capability, special features, trade-in considerations, expected lifecycle, warranty, maintenance availability, and environmental or energy efficiency considerations.

Respondents claiming to be manufacturers or authorized resellers of a specified brand-name product must provide:

(a) Product, catalog, model, and/or part number(s);

(b) Product description;

(c) Documentation demonstrating that the offered item meets all required salient characteristics;

(d) Quantity;

(e) Estimated price or cost;

(f) Shipping, handling, and/or installation charges; and

(g) Delivery timeframe after receipt of order.

Responses must also include the Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification. All offerors must be actively registered in the System for Award Management (SAM) at www.sam.gov.

https://www.sam.gov/

All responses must be received by November 2, 2026 at 9:00 AM EST and must reference solicitation number 75N98027Q00027. Responses may be submitted electronically to nicholas.capobianco@nih.gov.

(xv) Point of Contact:

Nicholas Capobianco Contracting Specialist National Institutes of Health Email: nicholas.capobianco@nih.gov mailto:nicholas.capobianco@nih.gov mailto:nicholas.capobianco@nih.gov

Title

NON-COMPETITIVE COMBINED SYNOPSIS / SOLICITATION