S02 - ATTACHMENT 3 - STATEMENT OF WORK - IRRADIATOR FOR COLONY OF HUMANIZED MICE - BRAND NAME OR EQUAL TO RAD SOURCE - 08-19-2026.pdf

B.3 STATEMENT OF WORK

STATEMENT OF WORK (SOW)

1. CONTRACTING OFFICER’S REPRESENTATIVE (COR):

Name: Tim Foley

Section: Research & Development Service (BT/151)

Address: VAMHCS, 10 North Greene Street Baltimore, Maryland 21201

Phone Number: 410-605-7000 x53421

Fax Number: 410-605-7906

E-Mail Address: timothy.foley2@va.gov

Technical Questions VA POC: Timothy Foley.

2. CONTRACT TITLE: Irradiator for Humanized Mice Core

3. BACKGROUND:

The VA Maryland Health Care System (VAMHCS) Research and Development (R&D) Service has received FY26 Lab Animal Major equipment (LAM) funding to establish a colony of ~400 mice with humanized immune systems. This will allow VAMHCS scientists to create more relevant animal models for preclinical biomedical research. Humanized mice enable the study of human immune mechanisms that underlie diseases disproportionately affect Veterans, including chronic viral infections (e.g, HIV), cancer, neuroinflammation, age-associated immune dysfunction, Gulf War Illness (GWI) and PTSD. Thus, humanized mice are crucial for bridging the gap between animal research and human clinical application, allowing for more accurate, "personalized" testing of treatments for Veteran-specific health challenges.

4. SCOPE: To create humanized mice, immunodeficient newborn pups will be exposed to x-ray radiation to irradicate their immune systems. Human CD34+ Hematopoietic Stem Cells (HSCs), isolated from human cord blood, will then be injected into mice and this will develop into immune systems which will have 30- 70% human characteristics. Treatments will then be trialed to better understand the molecular scientific mechanisms of how the disease interacts with the treatment.

IRRADIATOR SPECIFICATIONS: Brand name or equal to the Rad Source Technology RS 2000-Q2 X-ray Irradiator:

Line-Item Description Quantity

Rad Source RS 2000-Q2 Irradiator with:

• Self-contained X-ray emitter with non-isotopic operation/no radioactive source, requiring no nuclear licensing

1 each mailto:timothy.foley2@va.gov

• Dose uniformity ratio of 95% or greater

• Self-shielded requiring no specialized shielding in the room it operates in

• Meets all radiation safety requirements specified in Federal Regulation 21 CFR 1020.40

• 1,000-4,000 W generator

• Energy delivery output of at least 225 kV

• Electrical Requirements: 208-240 V, Single Phase, 30-50 A, 50-60 Hz

• Equipment Weight: Approx. 2,750-3,300 lbs

• Equipment Dimensions: 43-56” W x 75-76” H x 31-36” D

• Internal Chamber Dimensions: 17.5-25” W x 15.5-42” H x 16.75-27” D

• Data Recording Module (User ID, Date, Time, and Total Dose)

• Rodent cage- pie configuration preferred

Installation, Training, Warranty and RS 2000-Q2 1KW 12-month service agreement extended.

• Installation of the irradiator into room BB-120 once components are delivered. Installation includes assembly and calibration, dose mapping and radiation survey.

• Operational training for device usage after the installation is complete

• 1 year or 3,200 hours Warranty on Parts, Labor, and Travel

1 Each

5. SPECIFIC TASKS: The vendor will provide delivery of the irradiator, installation and training within 60 days of contract award. The place of performance is:

VA Maryland Health Care System Research and Development Veterinary Medical Unit

10 N. Green Street – BB-120 Baltimore, MD 21201

5.1 TASK 1 - ENTERPRISE MANAGEMENT CONTROLS.

5.1.1 Subtask 1 - Integration Management Control Planning. Provide the technical and functional activities at the required level for integration of all tasks specified within this

SOW. Include productivity and management methods such as quality assurance, progress/status reporting and program reviews. Provide centralized administrative, clerical, documentation and related functions.

The contractor will provide a brand name or equal to Rad Source Technologies

2000-Q2 X-ray Irradiator with:

Line-Item Description Quantity

Rad Source RS 2000-Q2 Irradiator with:

• Self-contained X-ray emitter with non-isotopic operation/no radioactive source, requiring no nuclear licensing

• Dose uniformity ratio of 95% or greater

1 each

• Self-shielded requiring no specialized shielding in the room it operates in

• Meets all radiation safety requirements specified in Federal Regulation 21 CFR 1020.40

• 1,000-4,000 W generator

• Energy delivery output of at least 225 kV

• Electrical Requirements: 208-240 V, Single Phase, 30-50 A, 50-60 Hz

• Equipment Weight: Approx. 2,750-3,300 lbs

• Equipment Dimensions: 43-56” W x 75-76” H x 31-36” D

• Internal Chamber Dimensions: 17.5-25” W x 15.5-42” H x 16.75-27” D

• Data Recording Module (User ID, Date, Time, and Total Dose)

• Rodent cage- pie configuration preferred

Installation, Training and Warranty (RS 2000-Q2 1KW 12-month service agreement extended).

• Installation of the irradiator into room BB-120 once components are delivered. Installation includes assembly and calibration, dose mapping and radiation survey.

• Operational training for device usage after the installation is complete

• 1 year or 3,200 hours Warranty on Parts, Labor, and Travel

1 Each

The COR should inspect and discuss with vendor to confirm that contracting tasks have been progressed and performed in accordance with SOW and in timely manner. He/She should report to evaluate the work in relation to contractual requirements.

DELIVERABLES:

The delivery of a Rad Source Technologies 2000-Q2 X-ray Irradiator

5.1.2 Subtask 2 - Contract Management. Prepare a Contract Management Plan describing the technical approach, organizational resources and management controls to be employed to meet the cost, performance and schedule requirements throughout

Contract execution. Provide a monthly status report monitoring the quality assurance, progress/status reporting and program reviews applied to this contract.

The contractor will include delivery, equipment installation and training, and a one-year warranty in the purchase price.

Deliverables: The equipment installation and training status report generated by the installation technician upon completion of installation and training.

6. PERFORMANCE MONITORING:

Principle Investigator will ensure validity of work in cooperation with sales engineers if the need arises. Technical support is available for the equipment by phone and email for the project. On-site consulting M-F 7:30 AM-5 PM EST with advanced notice is also available at extra charge.

7. SECURITY REQUIREMENTS: N/A. No special security requirements are necessary

8. GOVERNMENT-FURNISHED EQUIPMENT (GFE)/GOVERNMENT-FURNISHED

INFORMATION (GFI).

No special security requirements are necessary

9. OTHER PERTINENT INFORMATION OR SPECIAL CONSIDERATIONS.

a. Identification of Possible Follow-on Work. N/A

b. Identification of Potential Conflicts of Interest (COI). N/A

c. Identification of Non-Disclosure Requirements. N/A

d. Packaging, Packing and Shipping Instructions.

The P.I. and vendor will discuss any special requirements for sample shipping and set up.

Items will be packaged and itemized on all invoices. The equipment will be delivered to the main receiving dock at 10 N Greene St, the dock is approximately 4 feet high, 10 feet deep, and 20 feet wide-

A box truck is recommended for delivery rather than a semi-trailer because of the navigation to the dock from the street. Upon delivery the components of the irradiator will be unloaded and unpacked, positioned in rooms BB-120 then assembled. The dimensions of room BB-120 are 175 square feet. Usage training will then be provided.

e. Inspection and Acceptance Criteria.

Acceptance based on quality of performance at set-up. Dose mapping and a radiation survey will be conducted by the vendor using handheld multi-radiation survey meter on the entirety of the unit. This is to ensure compliance with FDA requirements of an emission limit of 0.5 mR in one hour at any point 5 cm from the external surface.

10. RISK CONTROL: There are no risk factors of concern, VAMHCS Radiation Safety has noted x-ray irradiators are self-shielded without a radioactive isotope. The vendor will ensure that the irradiator is compliance with FDA requirements of an emission limit of 0.5 mR in one hour at any point 5 cm from the external surface.

11. PLACE OF PERFORMANCE.

VA Maryland Health Care System - Research and Development Veterinary Medical Unit

10 N. Green Street – BB-120 Baltimore, MD 21201

12. PERIOD OF PERFORMANCE: Delivery is expected within 60 days ARO.

13. GOVERNMENT TAX EXEMPT STATUS:

This acquisition will be made by the United States government and as such is exempt from all federal, state and local taxes.

12. INVOICING: Contractor shall submit a consolidated invoice monthly in arrears of the month for which services are being billed. One all-inclusive monthly invoice shall be provided, which shall contain an invoice number, contract number, obligations order number, and an itemized list of services provided. An acceptable master (all-inclusive) itemized list of services shall be agreed to between the Contractor and the COR prior to submission of the first invoice.

All invoices from the contractor shall be submitted electronically in accordance with VAAR Clause 852.232-72 Electronic Submission of Payment Requests.

VA’s Electronic Invoice Presentment and Payment System (IPPS) – The VA Financial Services Center (FSC) uses a third-party contractor, Tungsten, to transition vendors from paper to electronic invoice submission. Please go to this website to begin submitting electronic invoices, free of charge:

http://www.tungsten-network.com/US/en/veterans-affairs/.

More information on the VA FSC is available at: http://www.fsc.va.gov/einvoice.asp.

Vendor e-Invoice Set-Up Information:

To begin submitting your electronic invoices to the VA FSC for payment processing, free of charge, please contact Tungsten at the phone number below or email address:

Tungsten e-Invoice Setup Information: 1-877-489-6135 Tungsten e-Invoice Email: VA.Registration@Tungsten-Network.com.

If you have a question about the e-invoicing program or Tungsten, please contact the FSC at the Below phone number email address.

• FSC e-Invoice Contact Information: 1-877-353-9791

• FSC e-Invoice Email: vafsccshd@va.gov

13. CONTRACT TYPE: Firm-Fixed Priced Contract.

14. EVALUATIONS FACTOR:

i. Brand Name or Equal to Rad Source Technologies. Required features in accordance with (IAW) SOW.

http://www.tungsten-network.com/US/en/veterans-affairs/ http://www.fsc.va.gov/einvoice.asp mailto:VA.Registration@Tungsten-Network.com mailto:vafsccshd@va.gov

ii. OEM Authorization/distributor letter from the manufacturer is required for all quotes, if no OEM letter is supplied the vendor will be considered non-responsive and the vendor will be dis-qualified at the time RFI will close.

iii. Delivery Lead Times.

iv. Must provide destination pricing – FAR 52.247-34 (F.O.B)

v. Must be in our local system (IFCAP) at the time RFQ close to qualify for solicitation (RFQ).

vi. Completed Trade Agreements Certificate.

vii. The Government will evaluate offers in IAW with the policies & procedures of part 25 of the Federal Acquisition Regulation (FAR).

viii. Price.