Solicitation Number: 75N98026Q01167 DRAGEN Tier 3 Throughput License and v4 Server

COMBINED SYNOPSIS–SOLICITATION

Solicitation number 75N98026Q01167 is issued as a [ X ] RFQ [ ] RFP [ ] IFB Acquisition Title: Illumina DRAGEN Tier 3 Throughput License and v4 Server NAICS Code: 541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) NAICS Size Standard: 1,000 PSC Code: AJ12 - GENERAL SCIENCE AND TECHNOLOGY R&D SERVICES; GENERAL SCIENCE

AND TECHNOLOGY; APPLIED RESEARCH

Procedures: 12.201-1, Simplified procedures Anticipated award date: 9/20/2026

This is a combined synopsis/solicitation for commercial products or commercial services prepared in accordance with RFO FAR part 12. This announcement constitutes the only solicitation. Offers are being requested and a separate written solicitation will not be issued.

POINT OF CONTACT

Contract Specialist: Sandra Daniels Agency/Office: NIH/OALM Email: Sandra.daniels@nih.gov Phone: 301.827.7654

Contracting Officer Name: Shirley Ruiz-Lundgren Agency/Office: NIH/OALM Email: shirley.ruiz-lundgren@nih.gov Phone: 301.594.1915

SET-ASIDE STATUS

x ] Not Set-Aside [ ] Total Set-Aside [ ] Partial Set-Aside [ ] Local Area Set-Aside

Additional Notes: ________________________________________

DESCRIPTION OF REQUIREMENT

The NHGRI Undiagnosed Diseases Program (UDP) requires both the Illumina DRAGEN 500,000Gb annual throughput license and the Illumina DRAGEN Server v4 to maintain secure, compliant, and high performance secondary analysis of next generation sequencing (NGS) data.

DRAGEN serves as an essential computational supplement when UDP’s sequencing workload exceeds CIT High Performance Computing Center allocations, enabling timely processing of whole genome, whole exome, and transcriptome datasets for patients with rare and unresolved diseases. The current DRAGEN server, procured in 2017, has reached end of support. Its CentOS 7 operating system lost vendor support and security updates on June 30, 2024, increasing operational risk. In addition, the legacy dual Intel Xeon processors, 512 Gb RAM, and first generation FPGA acceleration hardware cannot support updated DRAGEN pipelines, including pangenome references and improved germline/somatic variant calling workflows.

These limitations reduce analytical accuracy, throughput, and system stability. To prevent analysis delays, maintain compliance with NIH IT security requirements, and sustain mission critical genomic interpretation capacity, the UDP must acquire both the updated throughput license and the next generation DRAGEN Server v4.

For supplies/products (as applicable):

National Stock Numbers (NSNs): __________________________________ Manufacturer: _____________________________________ Part Number: ______________________________________ Form/Fit/Function: _________________________________ Size/Dimensions: ___________________________________ Predominant Material: ______________________________ Quantity & Unit of Issue: ___________________________ Delivery Schedule: _________________________________ Planned Contract Duration: __________________________

LINE ITEMS

CLIN/Line Item No.:1 Description: Illumina DRAGEN Server v4_ Quantity: 1 Unit: 1 No: 2 Description: Illumina DRAGEN License Quantity: 1 Unit: 1

[ ] Options included: None

PERFORMANCE / DELIVERY

Place(s) of Delivery/Performance/Acceptance: UDP Translational Laboratory 5625 Fishers Lane, Room 5N03 Rockville, ND 20852

Delivery Date(s)/Period of Performance: 30 days after award FOB Point: Destination

TRADE AGREEMENTS

Items subject to WTO GPA or a Free Trade Agreement:

[ ] Yes:

[ ] FAR 52.225-3, Buy American–Free Trade Agreements–Israeli Trade Act: “One or more of the items under this acquisition is subject to Free Trade Agreements.”

[ ] FAR 52.225-5, Trade Agreements: “One or more of the items under this acquisition is subject to the World Trade Organization Government Procurement Agreement and Free Trade Agreements.”

[ ] FAR 52.225-11, Buy American-Construction Materials under Trade Agreements: “One or more of the items under this acquisition is subject to the World Trade Organization Government Procurement Agreement and Free Trade Agreements.”

[ ] FAR 52.225-23, Required Use of American Iron, Steel, and Manufactured Goods-Buy American Statute-Construction Materials under Trade Agreements: “One or more of the items under this acquisition is subject to the World Trade Organization Government Procurement Agreement and Free Trade Agreements.”

[ ] No

[ x] N/A – Unknown

TECHNICAL DATA

Technical data required to respond will be included in solicitation:

[] Yes

[ ] No:

Can be obtained: ______________________________________________________

[ x] N/A – Not Required

SMALL BUSINESS CONSTRUCTION

[ ] Yes:

Include definitization/change order information:

[x ] No

RESTRICTING COMPETITION (INCLUDING BRAND-NAME)

[ x] Yes:

Statutory authority: FAR 13.106-1(b)(1) Intended Source: Sole Source

Justification/Documentation Attached:

x[ ] Yes

[ ] No: ____________________[Insert Justification]_______________________

[ ] No

QUALIFICATION REQUIREMENTS

Offeror or product/service must meet a qualification requirement:

[ ] Yes

Qualification Requirement: _____________________________________________________ Qualification may be obtained from: ___________________________________________

[ ] No

EVALUATION AND AWARD BASIS

The Government will award a contract resulting from this solicitation to the responsible Offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered.

The following factors will be used to evaluate offers: Technical, Price and Past performance.

Additional Notes: ________________________________________

SOLICITATION PROVISIONS

52.203-18 PROHIBITION ON CONTRACTING WITH ENTITIES THAT REQUIRE CERTAIN INTERNAL

52.204-13 SYSTEM FOR AWARD MANAGEMENT—MAINTENANCE

52.212-1 INSTRUCTIONS TO OFFERORS—COMMERCIAL PRODUCTS AND COMMERCIAL

SERVICES

52.212-2 EVALUATION—COMMERCIAL PRODUCTS AND COMMERCIAL SERVICES

52.240-91 SECURITY PROHIBITIONS AND EXCLUSIONS

CONTRACT CLAUSES

52.203-17 CONTRACTOR EMPLOYEE WHISTLEBLOWER RIGHTS

52.203-18 PROHIBITION ON CONTRACTING WITH ENTITIES THAT REQUIRE CERTAIN INTERNAL

CONFIDENTIALITY AGREEMENTS OR STATEMENTS—REPRESENTATION

52.203-19 PROHIBITION ON REQUIRING CERTAIN INTERNAL CONFIDENTIALITY AGREEMENTS

OR STATEMENTS

52.204-13 SYSTEM FOR AWARD MANAGEMENT—MAINTENANCE

52.209-10 PROHIBITION ON CONTRACTING WITH INVERTED DOMESTIC CORPORATIONS

52.212-1 INSTRUCTIONS TO OFFERORS—COMMERCIAL PRODUCTS AND COMMERCIAL

SERVICES

52.212-2 EVALUATION—COMMERCIAL PRODUCTS AND COMMERCIAL SERVICES

52.212-4 TERMS AND CONDITIONS—COMMERCIAL PRODUCTS AND COMMERCIAL SERVICES

52.217-9 OPTION TO EXTEND THE TERM OF THE CONTRACT

52.219-14 LIMITATIONS ON SUBCONTRACTING

52.219-28 POSTAWARD SMALL BUSINESS PROGRAM REREPRESENTATION

52.219-30 NOTICE OF SET-ASIDE FOR, OR SOLE-SOURCE AWARD TO, WOMEN-OWNED SMALL

BUSINESS CONCERNS ELIGIBLE UNDER THE WOMEN-OWNED SMALL BUSINESS PROGRAM

52.219-33 NONMANUFACTURER RULE

52.222-3 CONVICT LABOR

52.222-19 CHILD LABOR—COOPERATION WITH AUTHORITIES AND REMEDIES

52.222-36 EQUAL OPPORTUNITY FOR WORKERS WITH DISABILITIES

52.222-50 COMBATING TRAFFICKING IN PERSONS

52.222-90 ADDRESSING DEI DISCRIMINATION BY FEDERAL CONTRACTORS

52.223-23 SUSTAINABLE PRODUCTS AND SERVICES

52.226-8 ENCOURAGING CONTRACTOR POLICIES TO BAN TEXT MESSAGING WHILE DRIVING

52.232-33 PAYMENT BY ELECTRONIC FUNDS TRANSFER—SYSTEM FOR AWARD MANAGEMENT

52.232-40 PROVIDING ACCELERATED PAYMENTS TO SMALL BUSINESS SUBCONTRACTORS

52.233-3 PROTEST AFTER AWARD

52.233-4 APPLICABLE LAW FOR BREACH OF CONTRACT CLAIM

52.240-91 SECURITY PROHIBITIONS AND EXCLUSIONS

52.247-34 F.O.B. DESTINATION

352.232-71 ELECTRONIC SUBMISSION OF PAYMENT REQUESTS

352.239-79 INFORMATION AND COMMUNICATION TECHNOLOGY ACCESSIBILITY

THIS SOLICITATION INCORPORATES PROVISIONS AND CLAUSES BY REFERENCE. THE FULL

TEXT OF PROVISIONS AND CLAUSES MAY BE ACCESSED ELECTRONICALLY AT

WWW.ACQUISITION.GOV .

SUBMISSION INSTRUCTIONS

Quotations shall be submitted electronically to Sandra Daniels via email to Sandra.daniels@nih.gov no later than 2pm (Eastern Time), September 11, 2025. Emails must reference Solicitation Number 75N98026Q01167 in the subject line.

All responsible sources may submit a quotation, bid, or proposal, as appropriate, which will be considered by the agency, if received by the response due date.

Additional Notes: ________________________________________