Division of Violence Prevention (DVP)

Notice of Funding Opportunity

Application due Wednesday, July 1, 2026

Research Grants for Preventing Interpersonal Violence and Suicide Among Youth and Young Adults (R01) Opportunity number: RFA-CE-26-020

Contents

Step 1: Review the Opportunity 4

Basic information 5

Eligibility 7

Agency priorities 11

Program description 14

Step 2: Get Ready to Apply 30

Find the application package 31

Get registered 31

Help applying 32

Step 3: Build Your Application 34

Application checklist 35

Application contents and format 36

Step 4: Understand Review, Selection, and Award 41

Application review 42

Award notices 50

Step 5: Submit Your Application 51

Submission requirements and deadlines 52

Step 6: Learn What Happens After Award 54

Post-award requirements and administration 55

Contacts and Support 58

Before you begin 3

Endnotes 61

Contents 2

Before you begin If you believe you are a good candidate for this funding opportunity, secure your SAM.gov and Grants.gov registrations now. If you are already registered, make sure your registrations are active and up-to-date.

SAM.gov registration (this can take several weeks) You must have an active account with SAM.gov. This includes having a Unique Entity Identifier (UEI).

See Step 2: Get Ready to Apply

Grants.gov registration (this can take several days) You must have an active Grants.gov registration. Doing so requires a Login.gov registration as well.

See Step 2: Get Ready to Apply

Apply by the application due date Applications are due by 11:59 p.m. Eastern Time on Wednesday, July 1, 2026.

To help you find what you need, this NOFO uses internal links. In Adobe Reader, you can go back to where you were by pressing Alt + Left Arrow (Windows) or Command + Left Arrow (Mac) on your keyboard.

Before you begin 3 https://sam.gov/ https://grants.gov/

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1:

Review the Opportunity

In this step

Basic information 5

Eligibility 7

Agency priorities 11

Program description 14

Basic information Centers for Disease Control and Prevention

National Center for Injury Prevention and Control (NCIPC)

Division of Violence Prevention (DVP)

Evaluating approaches to prevent interpersonal violence and suicide for youth and young adults.

Have questions?

See Contacts and Support.

Key facts

Opportunity name:

Research Grants for Preventing Interpersonal Violence and Suicide Among Youth and Young Adults (R01)

Opportunity number:

RFA-CE-26-020

Assistance listing: 93.136

NOFO version: original

Key dates

Application submission deadline: July 1, 2026

Informational call:

June 8, 2026

Optional letter of intent deadline:

June 15, 2026

Expected scientific review date:

July 31, 2026

Expected secondary review date:

August 10, 2026

Expected award date:

August 28, 2026

Expected start date:

September 30, 2026

Expiration date:

August 14, 2026

See Submit Your Application for other submission requirements and deadlines that may apply to this NOFO.

Summary The Centers for Disease Control and Prevention’s (CDC) National Center for Injury Prevention and Control (NCIPC) seeks research proposals, led by investigators, that will help advance understanding of approaches to prevent interpersonal violence and suicide among youth and young adults (ages 10 to 24 years).

This NOFO supports effectiveness research to evaluate innovative, evidence-based programs, practices, or policies to address risk for interpersonal violence and suicide, focusing on youth and young adult populations that are more highly burdened by these issues. This initiative supports proposals that meet at least one of the following objectives:

• Objective 1: Effectiveness research to evaluate innovative approaches with the potential for immediate or near-immediate benefits.

• Objective 2: Effectiveness research to evaluate implementation factors in evidence-based prevention approaches that are modified to be significantly or substantially different from the original approach.

• Objective 3: Research on the prevention of multiple forms of violence by evaluating the efficacy, effectiveness, and cost benefit of primary prevention programs, policies, or practices that prevent more than one form of interpersonal violence, suicide, or both.

Step 1: Review the Opportunity 5

Research priority topics include:

• Adverse childhood experiences (including child abuse and neglect, other forms of childhood victimization, and household challenges).

• Intimate partner violence (including teen dating violence).

• Sexual violence.

• Suicide.

• Youth violence.

• Cross-cutting prevention.

Funding details Funding type: Grant

Expected awards: 8 The number of awards is subject to available funds and program priorities.

Period of performance: 3 years in 12-month budget periods.

Application type: New

Expected total program funding over the performance period: $9,600,000

Expected total program funding per budget period: $3,200,000

Expected funding per applicant per budget period: $400,000

Maximum award amount per budget period: $400,000

Minimum award amount per budget period: $0

Step 1: Review the Opportunity 6

Eligibility Eligible applicants Only these types of organizations may apply.

• State governments.

• County governments.

• City or township governments.

• Special district governments

• Independent school districts.

• Public and state-controlled institutions of higher education.

• Native American tribal governments (federally recognized).

• Public housing authorities and Indian housing authorities.

• Native American tribal organizations, other than federally recognized tribal governments.

• Nonprofits having a 501(c)(3) status, other than institutions of higher education.

• Nonprofits without 501(c)(3) status, other than institutions of higher education.

• Private institutions of higher education.

• Faith-based organizations.

• For-profit organizations other than small businesses.

• Small businesses.

• Bona fide agents applying on behalf of state, territorial, local, and tribal government organizations.

Bona fide agents must submit documentation that demonstrates their arrangement with the eligible applicant. See Other Attachments form.

Responsiveness criteria We will review your application to make sure it meets these requirements.

These are the basic requirements you must meet to move forward in the competition. We won’t consider an application that:

• Is from an organization that doesn’t meet all eligibility criteria. See requirements in Eligibility.

• Is submitted after the application deadline.

Step 1: Review the Opportunity 7

Your proposed research and application must also address the following factors to qualify for funding under this NOFO. Applications that do not meet all criteria will be disqualified.

Your proposed research must:

• Focus on preventing interpersonal violence or suicide involving youth or young adults (ages 10 to 24 years). The Research Strategy section of your Research Plan must provide evidence of this.

• Evaluate an interpersonal violence or suicide prevention program, policy, or practice. Examples of studies that will NOT be considered include:

◦ Etiologic research to examine the prevalence or correlates of behavior.

◦ Research to strengthen surveillance.

◦ Proposals to conduct development and feasibility testing.

• Evaluate a primary prevention approach. Primary prevention approaches aim to prevent violence before it occurs. Applications proposing to evaluate strategies that respond to interpersonal violence or suicide after it occurs will NOT be considered. Examples of programs that will NOT be considered include:

◦ Treatment and rehabilitation approaches (e.g., mental health treatment, physical rehabilitation).

◦ Medical care (e.g., treatment of physical injuries).

• NOT evaluate a program, policy, or practice that has already been evaluated through extensive efficacy and effectiveness research.

Examples of programs that will NOT be considered include:

◦ Alternatives to incarceration and reentry programs.

◦ Universal school-based violence prevention curricula.

◦ Pre-school enrichment with family engagement (e.g., Early Head Start).

◦ Early childhood home visitation (e.g., Nurse Family Partnership).

◦ Parenting and family relationship programs (e.g., Incredible Years, SafeCare).

◦ Intimate partner violence and sexual violence-related programs that have existing evidence of effectiveness from rigorous evaluations (e.g., Safe Dates, The Fourth R, Shifting Boundaries, GreenDot, RealConsent, Coaching Boys into Men).

◦ Programs, policies, or practices that are currently being evaluated under existing CDC-funded initiatives. A list of CDC-funded research

Step 1: Review the Opportunity 8 awards focused on violence and suicide prevention can be found on the CDC website.

• NOT evaluate approaches that are solely under the influence or control of the criminal justice system (i.e., policing, arrest, trial, sentencing, incarceration, mandated intervention and treatment approaches).

Your application must also include:

• A SF-424 Biographical Sketch for the project director (PD), principal investigator (PI), or Co-PI that documents their experience and expertise in interpersonal violence or suicide prevention, as described in the Qualifications for principal investigator or project director section.

• A proposed budget for each fiscal year that is less than or equal to the maximum funding amount of $400,000 for each budget period, as outlined in the Funding details section.

See the Application checklist to understand which elements of your application are part of the responsiveness criteria.

Application limits You must follow these limits on the number of applications your organization can submit.

You may submit more than one application per institution if each application is scientifically distinct. The principal investigator (PI) must be different for each application you submit.

Qualifications for principal investigator or project director We invite anyone who has the skills, knowledge, and resources needed to carry out the proposed research as a project director or principal investigator (PD/PI) to work with their organization or institution to apply.

The PD/PI or Co-PI must have experience and expertise that aligns with the proposal’s research strategy and demonstrates the ability to conduct the research and achieve the proposed objectives. Please see the Investigators scored criteria to learn more.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 9 https://www.cdc.gov/violenceprevention/fundinghub/fundedprograms/research-awards.html

PD/PI or Co-PI experience must be documented in your application as described in the Responsiveness criteria. Documentation should include at least one of the following:

• A first-authored, peer-reviewed publication, as defined by the NIH National Library of Medicine, in the relevant area of interpersonal violence or suicide prevention.

• Prior service as a principal investigator on a research grant in violence, suicide, injury, or crime prevention research.

Please note: Publication(s) or research experience must be cited (by bold text or highlight) in the SF-424 Biographical Sketch. The experience requirements may be met by the combined experiences of a PI and Co-PI (if applicable).

Cost sharing and matching funds This program has no cost-sharing requirement, meaning you do not need to contribute to the costs of this project.

If you choose to include cost-sharing funds, we won’t consider it during review. If you receive an award, we will include your voluntary commitment in the award, and you must report on the funds.

Post-award requirements

Before you apply, make sure you understand the requirements that come with an award.

See Step 6: Learn What Happens After Award for information on regulations that apply, reporting, and more.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 10 https://www.nlm.nih.gov/oet/ed/stats/03-700.html https://www.nlm.nih.gov/oet/ed/stats/03-700.html

Agency priorities Required alignment with CDC priorities The recipient of this award must implement any funds awarded under this NOFO to effectuate program goals or agency priorities in accordance with the Centers for Disease Control and Prevention (CDC) Priorities when authorized (for a full description of the CDC Priorities, please follow the provided hyperlink).

Funded activities must:

• Align with CDC’s core priorities by demonstrating a commitment to gold-standard science, transparency, and evidence-based practices.

• Support CDC’s mission to protect Americans from infectious and chronic diseases, strengthen public health systems, and advance innovation in health data and infrastructure.

• Contribute to rapid, science-driven responses to health threats, promote global health leadership, and adhere to principles of integrity, accountability, and compliance with applicable laws and federal priorities.

Consistent with CDC’s values, in carrying out any project funded under this NOFO, the recipient must adhere to the following principles where consistent with the authority and scope of the award and its activities:

• A commitment to gold-standard science and ensuring trust, transparency, and credibility: To build trust and improve CDC’s ability to lead during health crises, CDC will increase transparency, be more accountable, and follow strict, gold-standard scientific practices that are open, unbiased, and based on clear evidence.

• A commitment to global leadership: With staff in 63 countries and supporting 20 more, CDC’s Global Health Center:

◦ Works to prevent disease and advance emergency response.

◦ Detect health threats early, sends response teams, trains health workers, and provides personal protective equipment, vaccines, and medicines.

◦ Test disease samples from around the world to prepare for flu and other serious outbreaks.

◦ Has strengthened systems to better protect people at home and abroad after the COVID-19 outbreak.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 11 https://www.cdc.gov/about/cdc/index.html

• A commitment to ensuring rapid, evidence-based responses to crises:

During public health emergencies, ensuring rapid, science-driven responses is critical to minimizing harm, maintaining public trust, and restoring stability. To meet this goal, CDC must continue to strengthen its emergency response systems by:

◦ Streamlining internal processes.

◦ Improving risk communication strategies.

◦ Ensuring that laboratory capacity is fully equipped and tested—capable of rapidly developing and deploying scalable diagnostics during crises.

◦ Embedding structures for real-time learning, independent after-action reviews, and the application of lessons learned will ensure that each crisis response is smarter, faster, and more effective than the last.

• A commitment to vaccine safety and efficacy research: CDC will apply “gold-standard” science to all of its vaccine safety and effectiveness research. It will make vaccine data, research methods, and related datasets publicly available through simple data use agreements to improve transparency, accountability, and trust.

• A commitment to advancing our understanding of the causes of autism spectrum disorder (ASD), neurodevelopmental disorders (NDDs), and chronic disease: CDC conducts research and works with partners to better understand the causes of autism spectrum disorder, neurodevelopmental disorders, and chronic diseases. It will use new and existing data to study the rise in these conditions, including the increase in autism diagnoses from 1 in 150 to nearly 1 in 31 over the past 25 years.

• A commitment to modernizing public health infrastructure and enhancing our approach to health data: CDC will modernize public health infrastructure to create a faster, more efficient health system that can detect and respond to outbreaks in real time. This effort includes:

◦ Replacing data silos with integrated systems.

◦ Using advanced technology.

◦ Strengthening partnerships with states to ensure shared responsibility and strong local health data systems.

◦ Emphasizing collaboration across federal and state partners, resilient and adaptable systems, and accountability for funded programs to ensure they align with these priorities and federal requirements.

Step 1: Review the Opportunity 12

• Conflicts of interest: CDC will not support funding programs with conflicts of interest and ensure its work is based on transparent, unbiased science.

• Immigration: CDC funds will not be used to support or encourage illegal immigration, consistent with federal law.

• Protecting life and the family: CDC funds will not be used to support elective abortions, consistent with the Hyde Amendment, and will promote maternal health, the dignity of life, and strong families.

• Ending disorder on America’s streets: CDC will prioritize evidence-based programs that reduce homelessness, drug use, and public disorder. It will support comprehensive services for people with serious mental illness and substance use disorder. CDC will not support housing first strategies, harm-reduction or safe consumption sites, or related activities. To the extent allowable by federal law, CDC intends to give priority to grantees in States and municipalities that have laws and policies that support and enforce CDC’s priorities.

• Gender ideology and protecting children [PDF]: CDC will not fund medical interventions for minors seeking gender transition and will define sex based on biological criteria.

• DEI: CDC will not support DEI initiatives based on group identity and focus on merit-based, evidence-driven approaches to improve health outcomes.

• Parental rights: CDC will support policies that protect parental authority, promote transparency, and give parents greater control over their children’s education.

The recipient must demonstrate ongoing compliance with the full description and listing of CDC values and priorities, in all programs that are authorized to advance them, through program design, implementation, reporting, and evaluation.

Failure to meaningfully align funded activities with the applicable requirements may result in corrective action, additional reporting requirements, or other enforcement actions consistent with federal grant regulations found at 2 CFR Part 200 and the terms and conditions of this award. The full CDC Priorities Statement can be found here: Centers for Disease Control and Prevention (CDC) Priorities.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 13 https://opa.hhs.gov/sites/default/files/2025-11/gender-dysphoria-report.pdf

Program description Background Interpersonal violence and suicide are significant public health problems and leading causes of death among young people.[1] More than one million people require treatment in emergency departments for violence-related injuries every year.[2] Exposure to interpersonal violence or suicide can negatively affect a person’s health and development for their entire life.[3],[4]

Multiple forms of interpersonal violence, including child abuse and neglect, intimate partner violence, sexual violence, and youth violence, affect youth and young adults. Youth and young adults who experience violence may have a higher risk of suicide.[5],[6]

Interpersonal violence Intimate partner violence (IPV) is a serious, preventable public health problem that affects millions of Americans.[7],[8] It can start as soon as people start dating or having intimate relationships, often in adolescence. IPV that happens when individuals are dating in their teen years is often referred to as teen dating violence (TDV).

Sexual violence is another serious public health problem for youth and young adults. It’s linked to experiencing other types of violence and harm. For example, children who have been sexually abused are more likely to suffer poor physical and mental health later in life.[9] Adolescents who have experienced forced sexual activity in the past year are more likely than those who have not experienced that to report suicidal thoughts, planning, or behavior.[10]

Adverse childhood experiences, or ACEs, are a collection of experiences that may be traumatic to children and youth, and include violence, abuse, or neglect, as well as exposure to intimate partner violence in the home, mental illness, separation or divorce, substance abuse, and the incarceration of a parent before age 18.[11] These experiences are associated with over 40 adverse health outcomes, including toxic stress; physiological changes of the nervous, endocrine, and immune systems; risky health behaviors; chronic health conditions; infectious diseases; suicidal behavior; access to life opportunities; and early death.[12],[13],[14],[15]

Youth and young adults experience a high burden of interpersonal violence in their communities. For youth ages 10 to 24, homicide is the second leading

Step 1: Review the Opportunity 14 cause of death.[16] Beyond deaths, many more youth and young adults suffer nonfatal injuries due to interpersonal violence. Over 700,000 young people are treated and released in U.S. emergency departments each year for injuries resulting from violence.[17]

People hospitalized with violence-related injuries often experience long-term consequences, including physical disabilities and mental health conditions, including symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD).[18],[19],[20]

Suicide Suicide is a prevalent and preventable cause of death for youth and young adults. Suicide is among the top three leading causes of death for adolescents ages 10 to 14 years and for youth and young adults ages 15 to 24 years.[21] It’s also connected to experiences of interpersonal violence. Trauma, such as that experienced because of interpersonal violence, can increase the risk for suicide attempts or suicidal behavior.[22],[23]

Interpersonal violence and suicide often share risk and protective factors.

Despite these links, research often focuses on only one specific form of violence, which can limit our understanding of whether prevention approaches work for different types of violence.

Related work For over 30 years, NCIPC has been the nation’s leading public health authority on violence, including suicide, and injury prevention. CDC’s approach involves three elements:

• A focus on prevention.

• A science-driven approach to identify risks and patterns.

• Multidisciplinary collaboration to address the problem and keep people safe and healthy.

Information on the following can be found on the CDC website:

• CDC’s violence prevention initiatives.

• CDC’s National Violent Death Reporting System.

• CDC’s Mission for violence prevention.

CDC has released a suite of prevention resources to help communities use the best available evidence for the prevention of interpersonal violence and suicide. These resources describe general prevention strategies and provide

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 15 https://www.cdc.gov/violence-prevention/ https://www.cdc.gov/nvdrs/about/index.html https://www.cdc.gov/injury/divisions-offices/about-division-of-violence-prevention.html examples of specific approaches along with information about the evidence for these approaches. The resources are available on the CDC website.

Purpose The Centers for Disease Control and Prevention’s (CDC) National Center for Injury Prevention and Control (NCIPC) seeks research proposals, led by investigators, that will help advance understanding of approaches to prevent interpersonal violence and suicide among youth and young adults (ages 10 to 24 years).

This NOFO supports research to evaluate innovative primary prevention programs, practices, or policies to address interpersonal violence and suicide, focusing on youth and young adults.

Research priorities Research priorities include:

• Adverse childhood experiences (including child abuse and neglect, other forms of childhood victimization, and household challenges).

• Intimate partner violence (including teen dating violence).

• Sexual violence.

• Suicide.

• Youth violence.

• Cross-cutting prevention.

This NOFO aligns with NCIPC’s performance goal to conduct a research program to prevent injuries, violence, and suicide and to reduce their consequences. The NCIPC extramural violence prevention research program intends to:

• Build the scientific base for the prevention of interpersonal violence and suicide by advancing our understanding of innovative prevention strategies.

• Encourage professionals from a wide spectrum of disciplines to conduct research that informs interpersonal violence and suicide prevention efforts. Disciplines include epidemiology, behavioral and social sciences, medicine, biostatistics, public health, economics, urban planners, and others.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 16 https://www.cdc.gov/violence-prevention/php/resources-for-action/

Public health impact Interpersonal violence and suicide are significant public health problems and leading causes of death among young people. Exposure to interpersonal violence and suicide can increase future risk of violence, as well as negative, long-term health and life opportunity consequences, as described in the Background section. NCIPC is committed to preventing interpersonal violence and suicide and addressing the high risk for these issues among young people.

We expect that the results from the research funded under this NOFO will directly benefit communities seeking to implement evidence-based approaches to reduce interpersonal violence and suicide and risks among youth and young adults.

Approach Objectives and outcomes This section includes the outcomes we expect you to report progress on and achieve within the period of performance if you receive funding. Proposed research should address at least one of the following objectives. You must clearly indicate which objective(s) your research intends to address in your application’s Project Summary/Abstract, uploaded within the SF-424 R&R Other Project Information form.

Objective 1 Effectiveness research to evaluate innovative approaches with the potential for immediate or near immediate benefits (within 6 months) for reducing interpersonal violence or suicide among youth and young adult populations experiencing elevated burden.

There is an urgent need to identify more prevention strategies that can have proximate benefits for participants and their communities. Some prevention strategies can quickly reduce risk when they’re implemented well and reach the intended participants. These can include mentoring programs, hospital-community partnerships, youth employment or apprenticeship or other after-school programs, empowerment-based training, and rapid and remote access to help for suicide prevention.

Other strategies include creating or enhancing protective environments to reduce the risks associated with physical spaces and how they are used.

Step 1: Review the Opportunity 17

Innovative approaches are those that have not been rigorously evaluated for effectiveness in reducing interpersonal violence and suicide. You should explain why the proposed approach is innovative. Describe the process and theoretical or empirical support for the potential for immediate or near immediate (within 6 months after implementation) benefits for reducing the risk for interpersonal violence or suicide and risks among populations with higher burden. You are encouraged, but not required, to assess effects on two or more interpersonal violence or suicide outcomes.

Objective 2 Effectiveness research to evaluate implementation factors in evidence-based prevention approaches that are modified to be significantly or substantially different from the original approach.

• Evaluate key factors that might affect how well the program reduces interpersonal violence or suicide and risks among youth and young adult populations experiencing elevated burden.

There is a need to understand which methods, practices, and essential elements increase effectiveness of programs, policies, and practices in communities. Some areas of study might include:

• Understanding the most effective ways to facilitate community and youth leadership.

• Identifying recruitment approaches, training competencies, and skills that are needed to effectively implement, monitor, improve, or sustain an effective program, policy, or practice.

• Developing innovative ways to build collaborations and partnerships that strengthen the dissemination of findings that de-stigmatize youth and young adults and promote positive narratives.

• Improving the sustainability and expansion of evidence-based approaches.

You should explain why the proposed implementation factors could potentially increase effectiveness and benefits to reduce interpersonal violence or suicide and risks among populations of youth and young adults who experience a high burden of these issues. You are encouraged, but not required, to assess effects on two or more interpersonal violence or suicide outcomes.

In your Research Strategy, you should include evidence of effectiveness of the original approach and theoretical or empirical support for selection of implementation factors to be evaluated.

Step 1: Review the Opportunity 18

Objective 3 Research on the prevention of multiple forms of violence by evaluating the efficacy, effectiveness, and cost benefit of primary prevention programs, policies, or practices that prevent more than one form of interpersonal violence, suicide, or both. Forms of violence can include teen dating violence, intimate partner violence, sexual violence, ACEs including child abuse and neglect, and youth violence. Suicide-related outcomes include suicide, attempted suicide, and suicidal ideation.

Primary prevention programs, policies, and practices that prevent one of these outcomes might also prevent other violence or suicide-related outcomes. So, for this objective, you must examine the impact of the prevention approach on more than one violence- or suicide-related outcome.

You’re also encouraged to address the conditions that contribute to elevated rates of interpersonal violence, suicide, or both across some population groups.

For all objectives For all objectives, we expect you to provide theorical justification for the prevention programs, policies, or practices you’ll evaluate. For example, you may include a conceptual model or theory of change, with proposed mediators, for how the prevention approach will reduce interpersonal violence or suicide and risks among your selected population. The prevention approach you select should also be supported with epidemiological or behavioral research, or both, when possible.

Mediators help explain how the intervention leads to reductions in interpersonal violence or suicide. You’re expected to assess intervention processes and mediators as appropriate. Examples of process and mediator data include:

• Intervention or policy implementation fidelity data.

• Intervention exposure data.

• Changes in risk and protective factors specific to the proposed intervention.

Examples of outcome and impact data sources include:

• Vital statistics.

• Police records.

• Child welfare reports.

• School records.

Step 1: Review the Opportunity 19

• Injury-related hospital or emergency department data.

• Relevant self-reported behaviors.

In addition, we encourage you to include measures of conditions associated with violence and suicide. Examples these measures include:

• Neighborhood poverty.

• Limited access to high-quality education.

• High rates of unemployment and lack of employment that provides livable wages.

• Weak social connectedness.

The intent of this NOFO is to evaluate approaches to prevent interpersonal violence, suicide, or both. It will not support approaches outside of the objectives stated in the Responsiveness criteria.

Focus populations You should focus on interpersonal violence and suicide affecting youth and young adults (ages 10 to 24 years).

When feasible, you should use data (e.g., local, contextual, or program data) to identify adolescents and young adult populations who are at high risk relative to other youth for experiencing interpersonal violence or suicide in your jurisdiction and who will be the focus for the evaluated prevention approach. Identification of focus population(s) must not be discriminatory based on race, color, national origin, or other protected statuses.

Research design This NOFO supports rigorous research designs. Rigorous designs must:

• Include a control or comparison group.

• Be defined as one of the following:

◦ Experimental (i.e., randomized controlled trials).

◦ Quasi-experimental. For example:

▪ Designs involving matched comparison groups.

▪ Designs using propensity-score matching, instrumental variable methods, regression point displacement, regression discontinuity, pragmatic clinical trial, or time series designs.

Randomized trials are not feasible for some prevention strategies (e.g., policy evaluations). Alternative quasi-experimental designs are appropriate and acceptable. Rigorous designs should include data analytic plans that are

Step 1: Review the Opportunity 20 appropriate for that design and the prevention strategy, hypotheses, and data collection measures. Data analytic plans should also anticipate and evaluate the effects of threats to the internal and external validity of the specified research design.

We encourage you to use mixed-method approaches. In addition to quantitative methods, qualitative analyses may complement findings to help explain an approach’s impact on outcomes. For example, if you have community partners, you may propose conducting in-depth interviews or focus groups to further explore how the selected approach impacts elevated burden in some populations. You may also engage community members through other participatory research processes that help guide research activities through the life of the study.

Your application should:

• Describe how the selected prevention approach has the potential to reduce interpersonal violence or suicide and risks among the focus population.

• Propose evaluations of approaches that are new or previously implemented but have not been rigorously evaluated for effectiveness in reducing interpersonal violence or suicide.

You are also strongly encouraged to:

• Engage the community in the research process throughout the project (e.g., developing study methods, collecting data, interpreting results, and disseminating findings).

• Consider using approaches that are trauma-informed (i.e., healing centered, realizing the impact of trauma, integrating knowledge about trauma into practices, and avoiding re-traumatization).

• Test for cross-cutting reductions in multiple forms of violence and suicide impacting youth and young adults.

• Measure any unintended or harmful consequences of the prevention approach and differential effects of the approach on subpopulations, if applicable.

• Include cost measures when possible.

Step 1: Review the Opportunity 21

Data collection, acquisition, and analysis You must identify and describe appropriate data sources and provide evidence of your ability to acquire or collect sufficient (in both quantity and quality) data to conduct and complete the proposed research within the performance period. You should clearly describe and justify:

• Sampling methods.

• Sample size.

• Power estimates.

• Data collection methods for the primary outcome(s).

• Other proposed secondary measures and subgroup analyses.

You must specify the timeline for data acquisition, including access to previously collected data and primary data collection. Examples of data and data sources include:

• Injury-related hospital or emergency department data.

• Police and law enforcement data.

• Relevant self-reported behaviors.

• Administrative data from relevant agencies.

• Survey data collected prior to or in the context of the evaluation.

Appropriate data sources will vary according to the research approach and outcome measures you propose. We encourage you to:

• Include risk and protective factors (e.g., neighborhood poverty, educational attainment, employment opportunities) for the forms of interpersonal violence or suicide studied.

• Use multiple data sources to improve the validity and reliability of each outcome.

Collaborations We expect that for all applications, your organization and PD/PI will provide the necessary scientific and technical leadership to carry out the proposed research for the duration of the project. We expect that the proposed research work plan described in the Research Strategy section and SF-424 Research and Related budget of your application will reflect your organization’s leadership and engagement for the full performance period.

Your organization cannot “pass through” the funds to another entity to conduct most of the research or to provide the essential scientific or technical leadership needed to complete the project.

Step 1: Review the Opportunity 22

Community involvement NCIPC recognizes the importance of understanding the role of community conditions and community-centered research to complete the proposed work. We strongly encourage you to seek and include the meaningful involvement of communities, including state and local health departments, local governmental agencies, businesses, and community-based organizations in all phases of the research, translation, and dissemination of research results. We strongly encourage partnerships with community members who have lived experiences with interpersonal violence or suicide.

Other partnerships Partnerships between your institution and outside entities may be necessary or helpful to complete the proposed work. Your application must clearly describe each partner’s roles and responsibilities. This includes demonstrating your access to planned data sources and study populations, and all partnerships necessary to complete the proposed project.

You should clearly describe the nature and extent of the proposed partnership for the proposed research in the Research Strategy section of your application, including:

• Roles and responsibilities of the Principal Investigator(s).

• Roles and responsibilities of the outside entities or partner agencies.

• Existing working relationship between Principal Investigator(s) and outside entities or partner agencies.

• Plans for the proposed research.

• Nature and extent of the involvement of the applicant institution and outside entity.

• How the partnership will ensure implementation and sustainability of the proposed evaluation.

Each partner’s roles and responsibilities must be validated with a signed Data Sharing Agreement, Letter of Support (LOS), or Memorandum of Understanding (MOU). These documents must detail the partner’s commitment to resources, time, and personnel for the proposed research.

Applications that do not include a signed Data Sharing Agreement, LOS, or MOU from each partner may not be recommended for funding. (Refer to the Scored criteria section to review how collaborations and partnerships will be considered).

Step 1: Review the Opportunity 23

Early-stage investigators We encourage you to include early-stage investigators as members of the SF-424 Senior/Key Personnel research team to help build experience and expertise in violence or suicide prevention research. Students and other researchers-in-training are encouraged to participate. If you plan to incorporate training or mentorship roles into your research activities, you should describe the plans for the recruitment, training, and supervision of trainees or mentees and the ongoing quality assurance of their scientific products.

Evaluation and performance measurement We expect you to provide an evaluation and performance measurement plan with measures of effectiveness. You must clearly show:

• That accomplishing the proposed project objectives is feasible.

• That measures of effectiveness relate to the goals stated in the Purpose section and measure the intended outputs and outcomes.

• The outcomes you will be evaluating.

If applicable, performance measures should include:

• The number of participants recruited into the study.

• The participation rate.

• Types of samples collected.

Paperwork Reduction Act Any activities involving information collection from 10 or more individuals or organizations may require the Paperwork Reduction Act (PRA) approval. The PRA requires review and approval of the information collection by the White House Office of Management and Budget.

To determine if a proposed activity requires PRA approval, contact your scientific and research contact. Collections include items like surveys and questionnaires. If you have collections requiring PRA approval, CDC is responsible for working with OMB to gain the approval.

For more information about CDC’s requirements under PRA see CDC Paperwork Reduction Act Compliance.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 24 https://www.cdc.gov/scientific-integrity/php/public-information-collection/?CDC_AAref_Val=https://www.cdc.gov/os/integrity/reducepublicburden/index.htm https://www.cdc.gov/scientific-integrity/php/public-information-collection/?CDC_AAref_Val=https://www.cdc.gov/os/integrity/reducepublicburden/index.htm

Translation plan Your application should describe how significant findings of this research can be translated and used to promote, enhance, or advance the research into practice or inform public health policy.

You should describe:

• How results will be translated so they can be understood by a variety of partners, including policymakers, practitioners, public health programs, healthcare institutions, professional organizations, community groups, researchers, and other potential users.

• Plans to develop translation products for community partners to use for programmatic decisions, including selection and adaptation of prevention approaches and future funding opportunities.

• How the results of this project could be generalized to or adapted by populations and communities outside the study, as well as lessons learned to support future replication in another research or non-research setting (if relevant).

• Plans for engaging community partners in the interpretation and dissemination of the results.

• Plans to inform impacted communities about the proposed study and describe how research outcomes will support or enhance the prevention practice efforts of communities, practitioners, or both.

• How the results of this project could be used to sustain and/or expand the adoption of the approach within communities.

As a recipient, you may be required to meet in Atlanta with CDC/NCIPC staff during the performance period to review your progress and findings and discuss opportunities for widespread dissemination of your research achievements and lessons learned. Travel costs for attending this meeting must be included in your budget (see R&R Budget Form).

Step 1: Review the Opportunity 25

Funding policies and limitations Changes in HHS regulations As of October 1, 2025, HHS has adopted 2 CFR 200, with some exceptions included in 2 CFR 300. These regulations replace those in 45 CFR 75. You can find details in HHS Summary of Regulatory Changes, which is posted in the Grants.gov Related Documents tab for this opportunity.

General guidance All activities proposed in your application and budget narrative must align with applicable law, including but not limited to statutes, executive orders, federal regulations and applicable judicial holdings. Accordingly, discretionary awards shall not be used to fund, promote, encourage, subsidize, or facilitate;

racial preferences or other forms of racial discrimination by the recipient, including activities where race or intentional proxies for race will be used as a selection criterion for employment or program participation; denial by the recipient of the sex binary in humans, or the belief that sex is a chosen or mutable characteristic; illegal immigration; or any other initiatives that compromise public safety. If an application does not align, the application will not receive funding to the extent permitted by law and applicable court orders.

• You may use funds only for reasonable program purposes consistent with the award, its terms and conditions, and federal laws and regulations that apply to the award. If you have questions about these purposes, ask the grants management specialist.

• Your budget is arranged in eight categories: salaries and wages, fringe benefits, travel, equipment, supplies, contractual, other (includes consultant costs), and indirect costs.

• Support beyond the first budget year will depend on:

◦ Appropriation of funds.

◦ Satisfactory progress in meeting your project’s objectives.

◦ A decision that continued funding is in the government’s best interest.

• Generally, you may not use funds to purchase furniture or equipment.

Clearly identify and justify any such proposed spending in the budget.

• If we receive more funding for this program, we will consider:

◦ Funding more applicants.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 26 https://www.ecfr.gov/current/title-2/part-200 https://www.ecfr.gov/current/title-2/subtitle-B/chapter-III/part-300

◦ Extending the period of performance.

◦ Awarding supplemental funding.

Unallowable costs You may not use funds for:

• Clinical care, except as allowed by law.

• Pre-award costs, unless we give you prior written approval.

• Other than for normal and recognized executive-legislative relationships:

◦ Publicity or propaganda purposes, including preparing, distributing, or using any material designed to support or defeat the enactment of legislation before any legislative body.

◦ The salary or expenses of any grant or contract recipient, or agent acting for such recipient, related to any activity designed to influence the enactment of legislation, appropriations, regulation, administrative action, or executive order proposed or pending before any legislative body.

See Anti-Lobbying Restrictions for CDC Recipients.

For guidance on some types of costs that we restrict or do not allow, see 2 CFR 200.420, Considerations for Selected Items of Cost.

Indirect costs Indirect costs are those shared across multiple projects and not easily separated. Learn more at CDC Budget Preparation Guidelines.

To charge indirect costs you can select one of two methods:

Method 1 — Approved rate. If you currently have an indirect cost rate approved by your cognizant federal agency, you may use that rate.

Enclose a copy of the current approved rate agreement in your Other Attachments form.

Method 2 — De minimis rate. If you do not have a current negotiated indirect cost rate, you may elect to charge a de minimis rate (see 2 CFR 200.414(f)). This rate is 15% of modified total direct costs (MTDC). See the definition of MTDC (2 CFR 200.1). You can use this rate indefinitely.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 27 https://www.cdc.gov/grants/documents/Anti-Lobbying-Restrictions.pdf https://www.ecfr.gov/current/title-2/section-200.420 https://www.cdc.gov/grants/documents/budget-preparation-guidance.pdf https://www.ecfr.gov/current/title-2/section-200.414 https://www.ecfr.gov/current/title-2/section-200.414 https://www.ecfr.gov/current/title-2/part-200#p-200.1(Modified%20Total%20Direct%20Cost%20(MTDC))

Other indirect cost policies As described in 2 CFR 200.403(d), you must consistently charge items as either indirect or direct costs and may not double charge.

Indirect costs may include the cost of collecting, managing, sharing, and preserving data.

Salary rate limitation The salary rate limitation in the current appropriations act applies to this program. As of January 2026, the salary rate limitation is $228,000. We update this limitation when it changes.

Program income If you earn any money from your award-supported project activities (known as program income), you must use it for the purposes and under the conditions of the award. Find more about program income at 2 CFR 200.307.

Expanded authority For more information on expanded authority and pre-award costs, see the HHS Grants Policy Statement and speak to the grants management contact.

Pre-award costs may be allowable as an expanded authority, but only if we authorize the costs.

Public health data We require that awards include the needed costs and methods to share public health data. You may include the reasonable cost of sharing or archiving public health data as part of your requested budget for first-time or continuation awards. For more information, see Data Management and Access.

1. Review 2. Get Ready 3. Build 4. Understand 5. Submit 6. Award Contacts

Step 1: Review the Opportunity 28 https://www.ecfr.gov/current/title-2/part-200#p-200.403(d) https://www.ecfr.gov/current/title-2/section-200.307 https://www.hhs.gov/grants-contracts/grants/grants-policies-regulations/index.html https://www.cdc.gov/grants/additional-requirements/ar-25.html https://www.cdc.gov/grants/additional-requirements/ar-25.html

Human subjects We will restrict funds related to conducting research involving human subjects until the appropriate assurances and Institutional Review Board (IRB) approvals are in place. To lift the restrictions, we require copies of all current local IRB approval letters, local IRB-approved protocols, and CDC IRB approval letters, when applicable.

If the proposed research project involves more than one institution and will be conducted in the United States, we expect you to:

• Use a single Institutional Review Board (sIRB) to conduct the required ethical review.

• Include a single IRB plan in your research plan and PHS Human Subjects and Clinical Trials Information form, unless either of the following is true:

◦ Review by an sIRB would be prohibited by a federal, tribal, or state law, regulation, or policy.

◦ You provide…