Requirement 76.docx

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Attached to
Multiomic profiling of cardiometabolic diseases (Illumina)
Solicitation number
75N98026Q00733
Issued by

About this file

This is a requirements document for a one-time procurement of Illumina methylation and genotyping arrays to support genomics research. The National Institutes of Health National Human Genome Research Institute (NHGRI) Genomics Core seeks three Infinium Methylation EPIC v2 kits (96-sample capacity each) and three Infinium Global Diversity Array -8 v1.0 kits (96-sample capacity each) for the Center for Research on Genomics and Global Health. The methylation beadchips will be used to study methylation changes across the genome, while the genotyping arrays will analyze genetic variation and methylation quantitative traits in previously recruited study participants.

The NHGRI Genomics Core possesses the specialized equipment and technical expertise required for processing, including an Illumina iScan system, Illumina Autoloader, and Tecan Liquid Handling Robot for automated sample processing. The entire genotyping work is expected to be completed within a one-year period of performance. This procurement is issued as a pre-solicitation (Solicitation Number 75N98026Q00733) by the Department of Health and Human Services National Institutes of Health Office of Logistics and Acquisition Operations.

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Text version

Requirements:

Purpose and Objectives:

This order is for methylation and genotyping arrays produced and manufactured by Illumina. The methylation beadchips are designed specifically for studying methylation changes across the genome while the genotyping arrays are designed for studying genetic variation across the genome. The Center for Research on Genomics and Global Health will use methylation beadchips and genotyping arrays to study gene methylation, genetic variations, and methylation quantitative traits in previously recruited participants. The methylation and genotypes will be generated by the NHGRI Genomics Core, which has the necessary equipment and expertise for efficient processing of Illumina SNP beadchips. The Core has an Illumina iScan, Illumina Autoloader, and a Tecan Liquid Handling Robot for automated processing of samples.

Period of Performance:

This is a one-time-use product, and the genotyping is expected to be completed within 1-year.

Contractor Requirements:

1. The vendor shall provide:

· (3) Infinium Methylation EPIC v2 kits (96-sample kits)

· (3) Infinium Global Diversity Array -8 v1.0 Kit (96 samples)

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