Amendment_5_N01CN55003-47.pdf

RFP Number : N01CN55003-47 Amendment 5

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OFFICE OF ACQUISITIONS

NATIONAL CANCER INSTITUTE

REQUEST FOR PROPOSAL NUMBER: N01CN55003-47

Amendment No.: 5

Date of Issuance: 02/26/2015

The above numbered Request For Proposal (RFP) is amended as set forth below. The hour and date specified for receipt of Offerors remains unchanged: 3/30/15 2:00PM EST.

Offerors MUST acknowledge receipt of the amendment prior to the hour and the date specified in the solicitation or as amended, by separate letter, telegram, or Electronic Mail which includes a reference to the RFP and Amendment number(s). For your convenience, the Proposal Intent Response Form is provided in SECTION J - List of Attachments of this RFP, for this purpose.

FAILURE OF YOUR ACKNOWLEDGMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERORS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.

This Amendment provides responses to additional questions received on 2/26/15, as stated below:

Question 1: The RFP asks for us to nominate a novel and specific inhibitor of Mdm2/MdmX. We are not sure how to interpret this- should we be nominating an inhibitor that inhibits both, or are we being asked to pick an inhibitor that can target either one of these proteins?

Response 1: The offeror should nominate a novel inhibitor to target either Mdm2 or MdmX.

Question 2: Also, will the subcontract institutions on our proposal need to acknowledge the amendments as the prime is required to do?

Response 2: No. The prime contractor is expected to communicate the amendments to their proposed subcontracts.

END OF AMENDMENT 5.