Sol_75N98026Q00369_Amd_0002.pdf

REQUEST FOR QUOTATION

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National Institutes of Health OD - Office of Logistics and Acquisition Operations 6100 Executive Blvd., Room 6B05 Bethesda, MD 20892-7511

75N98026Q00369/0002

NICHOLAS CAPOBIANCO

+10

000-000000

05/15/2026

ED

Multiple

The purpose of this COMBINED SYNOPSIS /

SOLICITATION (COMPETITIVE) is to obtain

Next Generation Sequencing (NGS) services to support clinical and research activities related to bone marrow failure syndromes, including aplastic anemia and related disorders.

Period of Performance: 06/01/2026 to

05/31/2027

The following FAR clauses and Provisions are applicable to this award.

FAR 52.204-13 System for Award

Management Maintenance (Oct 2018)

FAR 52.204-18 Commercial and Government

Continued...

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OPTIONAL FORM 336 (4-86)

Sponsored by GSA FAR (48 CFR) 53.110

ITEM NO.

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NSN 7540-01-152-8067

75N98026Q00369/0002

Entity Code Maintenance (Aug 2020)

HHSAR 352.222-70, Contractor Cooperation in

Equal Employment Opportunity Investigations

(Dec 2015)

FAR 52.212-4 Contract Terms and Conditions -In addition to all the applicable commercial

Products and Commercial Services (Nov 2023)

FAR 52.212-5 Contract Terms and Conditions

Required to Implement Statutes or Executive

Orders/Commercial Products and Commercial

Services (Jan 2025)

FAR 52.217-8 Option to Extend Services (Nov

1999)

FAR 52.252-2 CLAUSES INCORPORATED BY REFERENCE

Questions and Answers

Solicitation No. 75N98026Q00369

The following questions were received regarding Solicitation No. 75N98026Q00369. The Government provides the following responses and clarifications.

Question 1:

Does the 10-calendar-day turnaround requirement include extraction through final analysis, or sequencing and analysis only?

Response:

Yes. The required turnaround time includes the complete workflow from specimen receipt through final analysis and reporting.

Question 2:

The solicitation references Single Primer Extension (SPE) chemistry. Is the contractor required to use this methodology, or will equivalent methodologies such as hybrid capture be considered acceptable?

Response:

The Government requires sequencing methodologies that maintain compatibility and comparability with existing longitudinal research datasets and ongoing clinical research protocols. Alternative methodologies that materially alter comparability, consistency, or continuity of longitudinal sequencing data may not be considered technically acceptable.

Question 3:

Would the Government consider modifying the turnaround time requirement to allow for a longer standard processing timeline?

Response:

No. The Government requires a turnaround time of ten (10) calendar days or less to support ongoing clinical and research activities.

Question 4:

Is CLIA certification required?

Response:

Yes. The contractor shall maintain current CLIA certification for performance of the required laboratory testing services.

Additional Clarification

The Government emphasizes that maintaining consistency and reproducibility of longitudinal sequencing data associated with ongoing clinical research protocols is a material requirement of this acquisition.

All other terms and conditions remain unchanged.

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