Amended_Attachment 18 - Proposed Task Order 1_Amendment 02.pdf

PROPOSED TASK ORDER 1

RFP 75N95021R00051

ATTACHMENT 18

PROPOSED TASK ORDER NUMBER 1

STATEMENT OF WORK

“Development and Maintenance of a Multigenotypic Aged Mouse Colony”

Task Order Number: 1

INITIATOR'S REQUEST

I. Period of Performance:

Twelve (12) months from date of award. The Government intends to award this task order at the time of award of the Indefinite Delivery Indefinite Quantity (IDIQ) contract.

II. Task Order 1 Description:

The purpose of this task order is for the re-derivation of foundation stocks for two (2) inbred strains of laboratory mice and the development and maintenance of the breeding and aging colonies for the two inbred strains and one hybrid strain. Where not specified below, all requirements of the Contract Statement of Work (SOW) shall be followed. [References in parentheses at the end of each paragraph refer to the section of the Contract SOW addressing the work specified in the Task.]

III. Task Order Scope:

The Contractor shall:

A. Within 60 calendar days of the start date of the contract, the Contractor shall acquire the genotypes (foundation stock) described herein and as directed by the Contracting Officer’s Representative (COR). Alterations in the genotypes entered require the specific written approval of the Contracting Officer. The two genotypes are C57BL/6J and BALB/cBy. The foundation stock shall be re-derived, and the Contractor shall provide the COR with documentation of the health status and genetic purity of the re-derived stock within 120 calendar days after the birth of re-derived litters. (Contract SOW Task Areas 1 and 2)

B. The Contractor shall develop breeding colonies consisting of two or three tiers:

foundation colony, and expansion and/or production colonies, dependent on the entry levels required for the aging colonies. The numbers of breeding mice to be maintained shall be at a level that permits the addition of male and female weanling mice to the aging colony at the rate required for each colony segment as described herein (Contract SOW Task Area 3):

PROPOSED TASK ORDER 1

RFP 75N95021R00051

ATTACHMENT 18

Strain Sex Total Entered

C57BL/6 Male 4700

C57BL/6 Female 3200

BALB/cBy Male 425

BALB/cBy Female 425

CB6F1 Male 50

CB6F1 Female 50

C. The Contractor shall provide discrete production space for each aging colony segment and mice shall be maintained within each aging colony barrier until scheduled for removal (shipment or sacrifice) or natural expiration of the animal. The Contractor shall provide animals for both in-house and independent health monitoring.

(Contract SOW Task Area 4)

D. The mice shall be raised under conditions conforming to all requirements specified in the contract SOW. (Contract SOW Task Area 5)

E. Mice from the aging mouse colony shall be distributed to investigators or laboratories only as specified by the COR or the designated representative of the COR. (Contract SOW Task Area 6)

F. The following reports shall be provided to the COR and Contracting Officer:

1. Post-re-derivation Health and Genetic Monitoring Report

2. Breeding Colony Development Reports

3. Semi-annual Progress Reports

4. Weekly Inventory Report (if applicable)

5. Health Monitoring Reports (if applicable)

6. Genetic Monitoring Reports

7. Individual Postmortem Reports (if applicable)

(Contract SOW Task Area 7)