Attachment 005 BoronTrifluorideMethanol SDS.pdf

Aldrich - B1252

The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

Version 6.22 Revision Date 08/22/2023

Print Date 02/10/2024

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers

Product name : Boron trifluoride-methanol solution

Product Number : B1252

Brand : Aldrich

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Synthesis of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Inc.

3050 SPRUCE ST

ST. LOUIS MO 63103

UNITED STATES

Telephone : +1 314 771-5765

Fax : +1 800 325-5052

1.4 Emergency telephone

Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)

Flammable liquids (Category 2), H225

Acute toxicity, Oral (Category 3), H301

Acute toxicity, Inhalation (Category 3), H331

Acute toxicity, Dermal (Category 3), H311

Skin corrosion (Category 1A), H314

Serious eye damage (Category 1), H318

Specific target organ toxicity - single exposure (Category 1), Eyes, Central nervous system, H370

Specific target organ toxicity - repeated exposure, Inhalation (Category 2), Kidney, H373

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 GHS Label elements, including precautionary statements

Pictogram

Signal Word Danger

Hazard statement(s)

H225 Highly flammable liquid and vapor.

H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.

H314 Causes severe skin burns and eye damage.

H370 Causes damage to organs (Eyes, Central nervous system).

H373 May cause damage to organs (Kidney) through prolonged or repeated exposure if inhaled.

Precautionary statement(s)

P210 Keep away from heat/ sparks/ open flames/ hot surfaces. No smoking.

P233 Keep container tightly closed.

P240 Ground/bond container and receiving equipment.

P241 Use explosion-proof electrical/ ventilating/ lighting/ equipment.

P242 Use only non-sparking tools.

P243 Take precautionary measures against static discharge.

P260 Do not breathe mist or vapors.

P264 Wash skin thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P271 Use only outdoors or in a well-ventilated area.

P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.

Rinse mouth.

P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.

P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor.

P305 + P351 + P338 +

P310

IF IN EYES: Rinse cautiously with water for several minutes.

Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/ doctor.

P307 + P311 IF exposed: Call a POISON CENTER or doctor/ physician.

P362 Take off contaminated clothing and wash before reuse.

P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.

P403 + P233 Store in a well-ventilated place. Keep container tightly closed.

P403 + P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

P501 Dispose of contents/ container to an approved waste disposal plant.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS

Strong hydrogen fluoride-releaser

SECTION 3: Composition/information on ingredients

3.2 Mixtures

Component Classification Concentration

Methanol

CAS-No.

EC-No.

Index-No.

Registration number

67-56-1

200-659-6

603-001-00-X

01-2119433307-44-

XXXX

Flam. Liq. 2; Acute Tox. 3;

STOT SE 1; H225, H301,

H331, H311, H370

Concentration limits:

>= 10 %: STOT SE 1,

H370; 3 - < 10 %: STOT

SE 2, H371;

>= 90 - <=

100 % boron trifluoride-methanol complex

CAS-No.

EC-No.

373-57-9

206-766-4

Flam. Liq. 2; Acute Tox. 4;

Acute Tox. 2; Skin Corr.

1A; Eye Dam. 1; STOT SE

3; STOT RE 2; Aquatic

Acute 3; H225, H302, H330, H314, H318, H335, H373, H402

>= 10 - < 20

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures

General advice

Consult a physician. Show this material safety data sheet to the doctor in attendance.Consult a physician. Show this material safety data sheet to the doctor in attendance.First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact

First treatment with calcium gluconate paste.In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

In case of eye contact

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.

Remove contact lenses.

If swallowed

After swallowing: fresh air. Make victim drink ethanol (e.g. 1 drinking glass of a 40% alcoholic beverage). Call a doctor immediately (mention methanol ingestion). Only in exceptional cases, if no medical care is available within one hour, induce vomiting (only in fully conscious persons) and make victim drink ethanol again (approx. 0.3 ml of a 40% alcoholic beverage/kg body weight/hour). Do not attempt to neutralise.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section

2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture

Carbon oxides

Hydrogen fluoride

Borane/boron oxides

Combustible.

Pay attention to flashback.

Vapors are heavier than air and may spread along floors.

Development of hazardous combustion gases or vapours possible in the event of fire.

Forms explosive mixtures with air at ambient temperatures.

5.3 Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

5.4 Further information

Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

6.2 Environmental precautions

Do not let product enter drains. Risk of explosion.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions

(see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.

Chemizorb®). Dispose of properly. Clean up affected area.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.

Storage stability

Recommended storage temperature

2 - 8 °C

Moisture sensitive. Handle under nitrogen, protect from moisture. Store under nitrogen.

Storage class

Storage class (TRGS 510): 3: Flammable liquids

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

Component CAS-No. Value Control parameters

Basis

Methanol

67-56-1

TWA 200 ppm

USA. ACGIH Threshold Limit

Values (TLV)

Remarks Danger of cutaneous absorption

STEL 250 ppm

USA. ACGIH Threshold Limit

Values (TLV)

Danger of cutaneous absorption

ST 250 ppm

325 mg/m3

USA. NIOSH Recommended

Exposure Limits

Potential for dermal absorption

TWA 200 ppm

260 mg/m3

USA. NIOSH Recommended

Exposure Limits

Potential for dermal absorption

TWA 200 ppm

260 mg/m3

USA. Occupational Exposure

Limits (OSHA) - Table Z-1

Limits for Air Contaminants

PEL 200 ppm

260 mg/m3

California permissible exposure limits for chemical contaminants (Title 8, Article

107)

Skin

C 1,000 ppm

California permissible exposure limits for chemical contaminants (Title 8, Article

107)

Skin

STEL 250 ppm

325 mg/m3

California permissible exposure limits for chemical contaminants (Title 8, Article

107)

Skin

TWA 200 ppm

260 mg/m3

USA. Table Z-1-A Limits for Air

Contaminants (1989 vacated values)

Skin notation

STEL 250 ppm

325 mg/m3

USA. Table Z-1-A Limits for Air

Contaminants (1989 vacated values)

Skin notation

Biological occupational exposure limits

Component CAS-No. Parameters Value Biological specimen

Basis

Methanol 15 mg/l Urine ACGIH -

Biological

Exposure Indices

(BEI)

Remarks End of shift (As soon as possible after exposure ceases)

8.2 Exposure controls

Appropriate engineering controls

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Full contact

Material: butyl-rubber

Minimum layer thickness: 0.3 mm

Break through time: 480 min

Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M)

Splash contact

Material: Nitrile rubber

Minimum layer thickness: 0.4 mm

Break through time: 30 min

Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Flame retardant antistatic protective clothing.

Respiratory protection

Recommended Filter type: Filter type ABEK

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

required when vapours/aerosols are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid

Color: colorless

b) Odor No data available

c) Odor Threshold No data available

d) pH No data available

e) Melting point/freezing point

f) Initial boiling point No data available and boiling range

g) Flash point 9.7 °C (49.5 °F)

h) Evaporation rate No data available

i) Flammability (solid, gas)

No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapor pressure No data available

l) Vapor density No data available

m) Density 0.859 g/cm3

Relative density No data available

n) Water solubility No data available

o) Partition coefficient:

n-octanol/water

No data available

p) Autoignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties Not classified as explosive.

t) Oxidizing properties none

9.2 Other safety information

SECTION 10: Stability and reactivity

10.1 Reactivity

Vapors may form explosive mixture with air.

10.2 Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

10.3 Possibility of hazardous reactions

No data available

10.4 Conditions to avoid

Warming.

10.5 Incompatible materials

Acids, Oxidizing agents, Alkali metals, Acid chlorides, Acid anhydrides, Reducing agents, Boron trifluoride reacts vigorously with alkyl nitrates after an induction period up to several hours. Reacts with alkali or alkaline earth metals. Do not use mercury manometers as boron trifluoride is soluble in mercuryMagnesium, zinc alloys, various plastics, Strong oxidizing agentsAlkali metals, Boron trifluoride reacts vigorously with alkyl nitrates after an induction period up to several hours. Reacts with alkali or alkaline earth metals. Do not use mercury manometers as boron trifluoride is soluble in mercury

10.6 Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Mixture

Acute toxicity

Acute toxicity estimate Oral - 107.55 mg/kg

(Calculation method)

Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.

Acute toxicity estimate Inhalation - 4 h - 2.04 mg/l - vapor(Calculation method)

Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract

Acute toxicity estimate Dermal - 333.44 mg/kg

(Calculation method)

Skin corrosion/irritation

Remarks: Mixture causes severe burns.

Serious eye damage/eye irritation

Remarks: Mixture causes serious eye damage.

Risk of blindness!

Respiratory or skin sensitization

No data available

Germ cell mutagenicity

No data available

Carcinogenicity

IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.

OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

Mixture causes damage to organs. - Eyes, Central nervous system

Specific target organ toxicity - repeated exposure

Mixture may cause damage to organs through prolonged or repeated exposure.

- Kidney

Aspiration hazard

11.2 Additional Information

Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea

Vomiting, Fever, Rapid respiration, pneumonitis, pulmonary edema, Cough, wheezing, laryngitis, Shortness of breath, Headache, Abdominal pain

Fluoride ion can reduce serum calcium levels possibly causing fatal hypocalcemia.

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Other dangerous properties can not be excluded.

Handle in accordance with good industrial hygiene and safety practice.

Stomach - Irregularities - Based on Human Evidence

Components

Acute toxicity

Acute toxicity estimate Oral - 100.1 mg/kg

(Expert judgment)

Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table

3.1/3.2)

Symptoms: Nausea, Vomiting

Acute toxicity estimate Inhalation - 4 h - 3.1 mg/l - vapor

(Expert judgment)

Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table

3.1/3.2)

Symptoms: Irritation symptoms in the respiratory tract.

Acute toxicity estimate Dermal - 300.1 mg/kg

(Expert judgment)

Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table

3.1/3.2)

Skin corrosion/irritation

Skin - Rabbit

Result: No skin irritation

Remarks: (ECHA)

Remarks: Drying-out effect resulting in rough and chapped skin.

Serious eye damage/eye irritation

Eyes - Rabbit

Result: No eye irritation

Remarks: (ECHA)

Respiratory or skin sensitization

Sensitisation test: - Guinea pig

Result: negative

(OECD Test Guideline 406)

Germ cell mutagenicity

Based on available data the classification criteria are not met.

Test Type: Ames test

Test system: Salmonella typhimurium

Result: negative

Test Type: In vitro mammalian cell gene mutation test

Test system: Chinese hamster lung cells

Result: negative

Method: OECD Test Guideline 474

Species: Mouse - male and female - Bone marrow

Result: negative

Carcinogenicity

Did not show carcinogenic effects in animal experiments.

Reproductive toxicity

Based on available data the classification criteria are not met.

Specific target organ toxicity - single exposure

Causes damage to organs. - Eyes, Central nervous system

Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table

3.1/3.2)

Acute oral toxicity - Nausea, Vomiting

Acute inhalation toxicity - Irritation symptoms in the respiratory tract.

Specific target organ toxicity - repeated exposure

No data available boron trifluoride-methanol complex

Acute toxicity

LD50 Oral - Rat - male and female - 326 mg/kg

Remarks: The value is given in analogy to the following substances: Boron trifluoride dihydrate

LC50 Inhalation - Rat - 4 h - 1.21 mg/l - aerosol

(OECD Test Guideline 403)

Remarks: The value is given in analogy to the following substances: Boron Trifluoride

Dermal: No data available

No data available

Skin corrosion/irritation

Skin - Rabbit

Result: Corrosive

Serious eye damage/eye irritation

Eyes - Rabbit

Result: Corrosive

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

No data available

Reproductive toxicity

No data available

No data available

Specific target organ toxicity - single exposure

May cause respiratory irritation.

Remarks: The value is given in analogy to the following substances: Boron Trifluoride

Specific target organ toxicity - repeated exposure

Inhalation - May cause damage to organs through prolonged or repeated exposure.

- Kidney

Remarks: The value is given in analogy to the following substances: Boron Trifluoride

SECTION 12: Ecological information

12.1 Toxicity

Mixture

No data available

12.2 Persistence and degradability

No data available

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

12.6 Endocrine disrupting properties

No data available

12.7 Other adverse effects

No data available

Components

Methanol

Toxicity to fish flow-through test LC50 - Lepomis macrochirus (Bluegill) -

15,400.0 mg/l - 96 h

(US-EPA)

Toxicity to daphnia and other aquatic invertebrates semi-static test EC50 - Daphnia magna (Water flea) - 18,260 mg/l - 96 h

(OECD Test Guideline 202)

Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - ca. 22,000.0 mg/l - 96 h

(OECD Test Guideline 201)

Toxicity to bacteria static test IC50 - activated sludge - > 1,000 mg/l - 3 h

(OECD Test Guideline 209)

Toxicity to fish(Chronic toxicity)

NOEC - Oryzias latipes (Orange-red killifish) - 7,900 mg/l - 200 h

Remarks: (External MSDS) boron trifluoride-methanol complex

Toxicity to fish static test LC50 - Leuciscus idus (Golden orfe) - 22 - 46 mg/l -

96 h

(DIN 38412)

Remarks: The value is given in analogy to the following substances: Boron trifluoride dihydrate

Toxicity to daphnia and other aquatic invertebrates static test EC50 - Daphnia magna (Water flea) - 21.3 mg/l - 48 h

(ISO 6341)

Remarks: The value is given in analogy to the following substances: Boron trifluoride dihydrate

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product

Waste material must be disposed of in accordance with the national and local regulations.

Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

SECTION 14: Transport information

DOT (US)

UN number: 3286 Class: 3 (6.1, 8) Packing group: I

Proper shipping name: Flammable liquid, toxic, corrosive, n.o.s. (Methanol, boron trifluoride-methanol complex) (Methanol, boron trifluoride-methanol complex)

Reportable Quantity (RQ):

Poison Inhalation Hazard: No

IMDG

UN number: 3286 Class: 3 (6.1, 8) Packing group: I EMS-No: F-

E, S-C

Proper shipping name: FLAMMABLE LIQUID, TOXIC, CORROSIVE, N.O.S. (Methanol, boron trifluoride-methanol complex) (Methanol, boron trifluoride-methanol complex)

IATA

UN number: 3286 Class: 3 (6.1, 8) Packing group: I

Proper shipping name: Flammable liquid, toxic, corrosive, n.o.s. (Methanol, boron trifluoride-methanol complex) (Methanol, boron trifluoride-methanol complex)

IATA Passenger: Not permitted for transport

SECTION 15: Regulatory information

SARA 302 Components

This material does not contain any components with a section 302 EHS TPQ.

SARA 313 Components

The following components are subject to reporting levels established by SARA Title III, Section 313:

Revision Date

2007-07-01

SARA 311/312 Hazards

Fire Hazard, Acute Health Hazard, Chronic Health Hazard

Massachusetts Right To Know Components

Pennsylvania Right To Know Components

Methanol CAS-No.

California Prop. 65 Components

, which is/are known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.Methanol

2012-03-16

SECTION 16: Other information

Further information

The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.

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Version: 6.22 Revision Date: 08/22/2023 Print Date: 02/10/2024