Attachment 004 Acetaldehyde SDS.pdf

Sigma-Aldrich - 402788

The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

Version 6.11 Revision Date 01/05/2024

Print Date 01/13/2024

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers

Product name : Acetaldehyde

Product Number : 402788

Brand : Sigma-Aldrich

Index-No. : 605-003-00-6

CAS-No. : 75-07-0

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Synthesis of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Inc.

3050 SPRUCE ST

ST. LOUIS MO 63103

UNITED STATES

Telephone : +1 314 771-5765

Fax : +1 800 325-5052

1.4 Emergency telephone

Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)

Flammable liquids (Category 1), H224

Eye irritation (Category 2A), H319

Germ cell mutagenicity (Category 2), H341

Carcinogenicity (Category 1B), H350

Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335

Short-term (acute) aquatic hazard (Category 3), H402

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 GHS Label elements, including precautionary statements

Pictogram

Signal Word Danger

Hazard Statements

H224 Extremely flammable liquid and vapor.

H319 Causes serious eye irritation.

H335 May cause respiratory irritation.

H341 Suspected of causing genetic defects.

H350 May cause cancer.

H402 Harmful to aquatic life.

Precautionary Statements

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P210 Keep away from heat/ sparks/ open flames/ hot surfaces. No smoking.

P233 Keep container tightly closed.

P240 Ground/bond container and receiving equipment.

P241 Use explosion-proof electrical/ ventilating/ lighting/ equipment.

P242 Use only non-sparking tools.

P243 Take precautionary measures against static discharge.

P261 Avoid breathing mist or vapors.

P264 Wash skin thoroughly after handling.

P271 Use only outdoors or in a well-ventilated area.

P273 Avoid release to the environment.

P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.

P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/ doctor if you feel unwell.

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.

Remove contact lenses, if present and easy to do. Continue rinsing.

P308 + P313 IF exposed or concerned: Get medical advice/ attention.

P337 + P313 If eye irritation persists: Get medical advice/ attention.

P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.

P403 + P233 Store in a well-ventilated place. Keep container tightly closed.

P403 + P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

P501 Dispose of contents/ container to an approved waste disposal plant.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS

May form explosive peroxides.

Photosensitizer.

Lachrymator.

SECTION 3: Composition/information on ingredients

3.1 Substances

Synonyms : Ethanal

Formula : C2H4O

Molecular weight : 44.05 g/mol

CAS-No. : 75-07-0

EC-No. : 200-836-8

Index-No. : 605-003-00-6

Component Classification Concentration acetaldehyde

Flam. Liq. 1; Eye Irrit. 2A;

Muta. 2; Carc. 1B; STOT

SE 3; Aquatic Acute 3;

H224, H319, H341, H350, H335, H402

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures

General advice

Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Call in physician.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

In case of eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section

2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture

Carbon oxides

Combustible.

Pay attention to flashback.

Vapors are heavier than air and may spread along floors.

Development of hazardous combustion gases or vapours possible in the event of fire.

Forms explosive mixtures with air at ambient temperatures.

5.3 Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

5.4 Further information

Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

6.2 Environmental precautions

Do not let product enter drains. Risk of explosion.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions

(see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.

Chemizorb®). Dispose of properly. Clean up affected area.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.

Storage stabilityRecommended storage temperature

2 - 8 °C

Storage class

Storage class (TRGS 510): 3: Flammable liquids

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

Component CAS-No. Value Control parameters

Basis acetaldehyde

75-07-0

C 25 ppm

USA. ACGIH Threshold Limit

Values (TLV)

Remarks Suspected human carcinogen

Potential Occupational Carcinogen

TWA 200 ppm

360 mg/m3

USA. Occupational Exposure

Limits (OSHA) - Table Z-1

Limits for Air Contaminants

C 25 ppm

45 mg/m3

California permissible exposure limits for chemical contaminants (Title 8, Article

107)

8.2 Exposure controls

Appropriate engineering controls

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses Tightly fitting safety goggles

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

Material: butyl-rubber

Minimum layer thickness: 0.7 mm

Break through time: 480 min

Material tested:Butoject® (KCL 898)

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Splash contact

Material: butyl-rubber

Minimum layer thickness: 0.7 mm

Break through time: 480 min

Material tested:Butoject® (KCL 898)

Body Protection

Flame retardant antistatic protective clothing.

Respiratory protection

Recommended Filter type: Filter type AX

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

required when vapours/aerosols are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid, clear

Color: colorless

b) Odor pungent

c) Odor Threshold No data available

d) pH 5 at 20 °C (68 °F)

e) Melting point/freezing point

Melting point: -123.5 °C (-190.3 °F)

f) Initial boiling point and boiling range

21 °C 70 °F at 1,013 hPa

g) Flash point -38.89 °C (-38.00 °F) - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas)

No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 57 %(V)

Lower explosion limit: 4 %(V)

k) Vapor pressure 1,202 hPa at 25 °C (77 °F)

l) Vapor density 1.52 - (Air = 1.0)

m) Density 0.78 g/cm3 at 16 °C (61 °F)

Relative density No data available

n) Water solubility completely miscible

o) Partition coefficient:

n-octanol/water log Pow: 0.63 - Bioaccumulation is not expected.

p) Autoignition temperature

175 °C (347 °F) at 1,013 hPa

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties none

9.2 Other safety information

Relative vapor density

1.52 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity

Vapors may form explosive mixture with air.

10.2 Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Avoid exposure to air any longer than necessary so as to prevent peroxide formation.

Stable under recommended storage conditions.

Test for peroxide formation before distillation or evaporation. Test for peroxide formation or discard after 1 year.

10.3 Possibility of hazardous reactions

Vapors may form explosive mixture with air.

10.4 Conditions to avoid

Warming.

10.5 Incompatible materials

No data available

10.6 Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity

Oral: No data available

Inhalation: No data available

Dermal: No data available

Skin corrosion/irritation

Skin - Rabbit

Result: No skin irritation

(OECD Test Guideline 404)

Serious eye damage/eye irritation

Eyes - Rabbit

Result: Severe irritations

Remarks: (RTECS)

Remarks: Lacrimal irritation due to vapours.

conjunctivitis

Respiratory or skin sensitization

Maximization Test - Guinea pig

Result: negative

(OECD Test Guideline 406)

Germ cell mutagenicity

Suspected of causing genetic defects.

Test Type: Ames test

Test system: Escherichia coli/Salmonella typhimurium

Metabolic activation: with and without metabolic activation

Result: negative

Remarks: (ECHA)

Carcinogenicity

Presumed to have carcinogenic potential for humans

IARC: 2B - Group 2B: Possibly carcinogenic to humans (acetaldehyde)

1 - Group 1: Carcinogenic to humans (acetaldehyde)

IARC: 2B - Group 2B: Possibly carcinogenic to humans (acetaldehyde)

1 - Group 1: Carcinogenic to humans (acetaldehyde)

NTP: RAHC - Reasonably anticipated to be a human carcinogen (acetaldehyde)

OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

May cause respiratory irritation.

Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

11.2 Additional Information

RTECS: AB1925000

Blurred vision, Unconsciousness, Headache, Vomiting, Nausea, Pulmonary edema. Effects may be delayed., Convulsions, sneezing, Cough, Shortness of breath

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Liver - Irregularities - Based on Human Evidence

Liver - Irregularities - Based on Human Evidence

SECTION 12: Ecological information

12.1 Toxicity

Toxicity to fish static test LC50 - Pimephales promelas (fathead minnow) - 31 mg/l

- 96 h

Toxicity to daphnia and other aquatic invertebrates static test EC50 - Daphnia magna (Water flea) - ca. 48.3 mg/l - 48 h

Toxicity to algae static test EC10 - Pseudokirchneriella subcapitata - > 100 mg/l - 72 h

(OECD Test Guideline 201) static test ErC50 - Pseudokirchneriella subcapitata - > 100 mg/l - 72 h

(OECD Test Guideline 201)

12.2 Persistence and degradability

Biodegradability aerobic Biochemical oxygen demand - Exposure time 14 d

Result: 80 % - Readily biodegradable.

(OECD Test Guideline 301C)

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

12.6 Endocrine disrupting properties

No data available

12.7 Other adverse effects

No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product

Waste material must be disposed of in accordance with the national and local regulations.

Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

SECTION 14: Transport information

DOT (US)

UN number: 1089 Class: 3 Packing group: I

Proper shipping name: Acetaldehyde

Reportable Quantity (RQ): 1000 lbs

Poison Inhalation Hazard: No

IMDG

UN number: 1089 Class: 3 Packing group: I EMS-No: F-

E, S-D

Proper shipping name: ACETALDEHYDE

IATA

UN number: 1089 Class: 3 Packing group: I

Proper shipping name: Acetaldehyde

IATA Passenger: Not permitted for transport

SECTION 15: Regulatory information

SARA 302 Components

This material does not contain any components with a section 302 EHS TPQ.

SARA 313 Components

The following components are subject to reporting levels established by SARA Title III, Section 313:

CAS-No.

Revision Date

2013-02-08

SARA 311/312 Hazards

Fire Hazard, Acute Health Hazard, Chronic Health Hazard

Massachusetts Right To Know Components

Pennsylvania Right To Know Components acetaldehyde CAS-No.

California Prop. 65 Components

, which is/are known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.acetaldehyde

2007-09-28

SECTION 16: Other information

Further information

The information is believed to be correct but is not exhaustive and will be used solely as a guideline, which is based on current knowledge of the chemical substance or mixture and is applicable to appropriate safety precautions for the product. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its

Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.

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Version: 6.11 Revision Date: 01/05/2024 Print Date: 01/13/2024