Biomarker evaluation in young onset dementia from diverse populations (beyondd)

Ended Project Grant Awarded Last action

Award ID
R56AG075744
Recipient
Awarding agency
Obligated
$12,130,456

Award facts

Assistance listing
93.866 Aging Research
Completion date
Originally
Place of performance
San Francisco, CA 94143, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
/ project summary early onset dementia (EOD) is devastating because IT affects individuals at a time of life when they have peak personal and professional responsibilities and are actively contributing to society. Previous work has identified alzheimer's disease (ad) and frontotemporal lobar degeneration (ftld) as the most common causes of EOD. Despite this, most studies of EOD primarily have recruited non-latinx whites (NLW). Black and latinx adults bear a disparate and disproportionate burden of biological and sociocultural vulnerabilities that confer increased adrd risk in older persons, but the etiologies of dementia in younger members of these diverse populations (DPS) are not well understood. Dedicated and well-resourced efforts specifically tailored to study EOD in DPS, including identification of unique risk and resilience factors, are urgently needed. Plasma biomarkers of amyloid, TAU and neurodegeneration and remotely collected automated clinical and cognitive assessments could greatly reduce barriers to characterization of EOD in DPS, but most studies evaluating these technologies have been conducted in older NLW. The biomarker evaluation in young onset dementia from diverse populations (beyondd) longitudinal study will address these gaps in knowledge. This five-year longitudinal study will implement a scalable, intensive, and culturally-informed community-engaged research approach to remotely enroll 2,000 adults (

Transactions

Action Obligated Date
Amendment $0
Amendment $0
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Amendment $6,065,228
Original award $6,065,228

Subawards

Subrecipient Amount Awarded
Regents Of The University Of Michigan Continuation, no change $17,644
Regents Of The University Of Michigan The site will evaluate referred participants (from the Phase 1, Online/At Home Visit), to determine clinical phenotype. The evaluation will include clinical,… $77,400
Georgetown University Site: Georgetown University Site will perform an evaluation of referred participants to determine clinical phenotype. The evaluation will include clinical,… $93,600
University Of Puerto Rico Medical Sciences Campus Site Name: University of Puerto Rico Medical Sciences Campus Site will perform an evaluation of referred participants to determine clinical phenotype. The… $149,000
The University Of Texas Health Science Center At San Antonio STATEMENT OF WORK Sub Award PI : A. Campbell Sullivan PsyD Community Research Liaison (CRL): The CRL will take a primary role in recruiting participants from… $94,500
Mayo Clinic This project will enroll approximately 200 participants. All participants will have approximately one MRI visits throughout their participation in the trial.… $178,197
Regents Of The University Of Michigan The University of Michigan site will be responsible for working with the BEYONDD team study team based at UCSF to advise on the development of a protocol for… $50,887
Quest Diagnostics Incorporated Responsibilities of ExamOne: ExamOne, a wholly owned subsidiary of Quest Diagnostics, will perform the mobile specimen collection services as follows: 1.… $131,200
Northern California Institute For Research And Education, Inc. o Build online recruitment and assessment portal o Maximum of 10 surveys (including all surveys on the list provided by the BEYONDD team) in Qualtrics or… $833,084
Icahn School Of Medicine At Mount Sinai As Project MPI, Dr. Rivera Mindt will: 1) serve on the Administrative and Clinical teams with her fellow MPIs; 2) co-facilitate the interactions with the Remote… $1,427,202
Research Foundation Of The City University Of New York The Biomarker Evaluation in Young Onset Dementia from Diverse Populations (BEYONDD) longitudinal study will use an intensive, multi-faceted community-engaged… $129,604
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Quick answers

Who received award R56AG075744?

R56AG075744 was awarded to The Regents Of The University Of California. San Francisco by National Institute on Aging (National Institutes of Health) on September 15, 2022.

How much is award R56AG075744 worth?

$12,130,456 has been obligated on R56AG075744.

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