Training in neurotherapeutics for academic scientists
Active Project Grant Awarded Last action
- Award ID
- R25NS129110
- Recipient
-
University Of California, Davis UEI TX2DAGQPENZ5 Part of State Of California Controllers Office
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,083,769
Award facts
- Assistance listing
- 93.867 Vision Research
- Completion date 85% complete
- Funding agency
- National Eye Institute National Institutes of Health, Department of Health and Human Services
- Place of performance
- Sacramento, CA 95817, USA
Award details come from USAspending.gov.
Description
- Abstract
- This project will develop and implement a training program in neurotherapeutics discovery and development for faculty members and advanced postdoctoral fellows, centered around a 4-day short course that will provide the trainees with the various knowledge elements required to discover and advance a neurotherapeutic agent - either small molecule or biological - to IND. The course is offered in conjunction with the american society for experimental neurotherapeutics (asent). The training, which is designed to be applicable to diverse diseases of the nervous system, will equip students with a broad understanding of the various component steps in the neurotherapeutics drug discovery and development process. Students will learn how to identify a good drug discovery target; how to construct an assay; the elements of medicinal chemistry; how to conduct animal efficacy testing; the principles of adme studies, safety testing, and formulation; special considerations for development of biological products, including monoclonal antibodies, oligonucleotides and viral vector gene therapies; the steps required to prepare an IND document and the principles for interacting with the FDA; the principles of intellectual property as they relate to neurotherapeutics discovery and development; and how to seek funding for academic drug discovery research. They will also receive training in responsible conduct of research. Students will be equipped with the skills to develop and coordinate an entire drug discovery and development effort, and to work collaboratively with experts in each of the component areas. The training will combine didactic lectures with active engagement activities in which the students will be challenged to utilize the lecture material to work through their own drug discovery project plan with the guidance of the area experts. The 4-day short course will be offered annually, a total of five times. After attending the short course, trainees will participate in ongoing activities that provide continuing professional development through engagement with asent.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $260,000 | |
| Amendment | $222,700 | |
| Amendment | $8,200 | |
| Amendment | $8,401 | |
| Amendment | $261,117 | |
| Amendment | $261,117 | |
| Amendment | $261,117 | |
| Amendment | $261,117 | |
| Amendment | $270,000 | |
| Original award | $270,000 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The Johns Hopkins University | $139,556 | |
| The Johns Hopkins University | $118,049 |
Quick answers
Who received award R25NS129110?
R25NS129110 was awarded to University Of California, Davis by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on August 1, 2022.
How much is award R25NS129110 worth?
$2,083,769 has been obligated on R25NS129110.
Which agency awarded R25NS129110?
National Institute of Neurological Disorders and Stroke (National Institutes of Health) awarded R25NS129110, with funding from National Eye Institute (National Institutes of Health).
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