Functions of locus coeruleus norepinephrine neurons in decision making across multiple timescales
Active Project Grant Awarded Last action
- Award ID
- R01NS131984
- Recipient
-
The Johns Hopkins University UEI FTMTDMBR29C7
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $610,648
Award facts
- Assistance listing
- 93.372 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies
- Completion date 69% complete
- Place of performance
- Maryland, USA
Award details come from USAspending.gov.
Description
- Abstract
- Norepinephrine (NE) is a neurotransmitter released by a small number of neurons in the locus coeruleus (LC), with extensive innervation of the neocortex. Prior work in humans and other mammals led to the hypothesis that LC-NE neurons modulate multiple forms of decision making. This proposal aims to test this overall hypothesis by studying LC-NE neurons in mice performing multiple decision-making tasks. The behaviors to be studied include two types of flexible decision making: how to learn from reinforcement over tens of seconds to minutes in a dynamic choice task and how to rapidly change a motor program based on sensory feedback over hundreds of milliseconds to seconds. The goal of the project is to link action potentials from identified LC-NE neurons to both types of behavior, and determine how large populations of neurons in multiple cortical areas are modulated by NE input to achieve flexible behavior. Three aims test three hypothesis that address different mechanistic questions about the functions of norepinephrine in neocortex: 1) LC-NE neurons modulate reinforcement learning during a dynamic choice task; 2) norepinephrine regulates sensory-driven motor program switching; 3) LC-NE modulates orofacial and prefrontal cortex for effective reinforcement learning and motor program switching. Measurements and manipulation (activation and inactivation) of the activity of NE neurons and their targets in neocortex, during well-controlled behavioral tasks in mice, will enable testing these three hypotheses. Understanding the spatial and temporal dynamics of NE release in cortex will be necessary for understanding flexible decision making in general, and disorders of attention, arousal, and mood that rely on its function.
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Allen Institute | $45,659 |
Quick answers
Who received award R01NS131984?
R01NS131984 was awarded to The Johns Hopkins University by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on May 15, 2023.
How much is award R01NS131984 worth?
$610,648 has been obligated on R01NS131984.
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