Project Grant R01MH140020

Award Date 9/17/24
Completion Date 7/31/29
Dollars Obligated $1.5M
Funding Federal Agency
Office of the Director
Federal Grant Program
93.310
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
This federal Project Grant award of $361,975.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support the development of chemical probes to visualize and manipulate astrocytes, the brain's support cells, and their interactions with neurons. The funded research aims to expand on the awardee's preliminary work in designing chemical tags that can...
This Project Grant award for $725,422 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research investigating the role of striatal astrocytes and striosomes in modulating dopamine signals and behavioral state transitions. The Massachusetts Institute of Technology (MIT) will employ advanced methods including optogenetics, chemogenetics, and photometric imaging to study how astrocyte activity in the striatum causally affects...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $168,455.00 to New York University School of Medicine to conduct research investigating the functional roles of region-specific reactive astrocyte factors in neuroinflammation. The research aims to characterize how the expression of hepatocyte growth factor (HGF) in...
This federal Project Grant award of $446,126 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new bioassay to study astrocyte borders and profile their functional states in the context of diverse non-neural cell populations. The key objectives are to optimize the bioassay by combining injectable cellulose-based hydrogels with viral vectors to...
The University of Illinois has been awarded a $1,427,400 Project Grant by the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) federal grant program. The grant supports research aimed at establishing a multidimensional model of the interaction between astrocytes and distinct neuronal subpopulations within the prefrontal circuit. The research will integrate techniques for genetic/chemogenetic manipulation of astrocytic signaling and in vivo Ca2+ imaging of...
This $688,419 Project Grant award from the National Institute on Aging under the Aging Research federal grant program (CFDA 93.866) supports a 5-year research study investigating the mechanisms behind activity-dependent astrocyte glucose metabolism and its impact on adult hippocampal neurogenesis. The project aims to uncover how specific hippocampal interneurons regulate astrocyte glucose dynamics, the role of lactate in supporting newborn neuron survival, and whether astrocyte metabolic defects...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $2,503,949.00 to Rockefeller University to conduct research aimed at discovering new therapeutic targets for neurological diseases. The research focuses on understanding the downstream effects of genetic defects on different cell types...
This $1,008,977 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to understand human brain development and the origins of neurodevelopmental diseases. The award aims to study two recently discovered neural progenitor cell types found in the outer subventricular zone of the developing human brain, which are key...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division, a $2,554,313 federal Project Grant under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant, which runs from Sep 1, 2023 to Aug 31, 2026, will support research to determine if targeted in vivo manipulations of local circuit control...
This federal Project Grant award of $1,785,632 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to elucidate the cellular and behavioral functions of astrocytic dopamine signaling in the nucleus accumbens (NAc) and its role in cue-conditioned motivated behaviors and cue-induced cocaine relapse. The key objectives of the research are to characterize the role of NAc astrocytic dopamine D1 receptors and their downstream...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under CFDA 93.310 - Trans-NIH Research Support program totals $1,490,348 and is aimed at testing an integrative hypothesis about the role of astrocytes in the brain's neuromodulator signaling systems. The award, made to the Research Foundation For Mental Hygiene, Inc. (RFMH) doing business as the New York Psychiatric Center, will utilize state-of-the-art cellular imaging and spatial transcriptomics techniques to investigate how astrocytes, the most common brain cell type, serve as integrators of signals from key neuromodulator systems like serotonin, norepinephrine, dopamine, and acetylcholine. This transformative research will explore the impact of stress and aging on astrocyte function and its implications for neuropsychiatric diseases. The project includes a sub-award to The Trustees of Columbia University in the City of New York to support specialized aspects of the research. Completing these ambitious studies aims to elucidate a fundamental organizing principle of astrocyte function across the brain.

Generated 7/1/25, 4:36 AM