Identifying proteomics risk markers for abdominal aortic aneurysm

Active Project Grant Awarded Last action

Award ID
R01HL155209
Recipient
Awarding agency
Obligated
$7,772,892

Award facts

Assistance listing
93.837 Cardiovascular Diseases Research
Completion date 89% complete
Originally
Funding
  • $5,797,144.00 Federal
  • $1,975,748.00 Non-federal
Place of performance
Minnesota, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Abdominal aortic aneurysm (AAA) is an important cause of morbidity and mortality in older adults. AAA rupture carries a = 65% mortality rate. There are no direct pharmaceutical treatments for AAA, so the main management options are screening, secondary risk factor intervention, and surgical repair for large aaas, which carries risk. Our previously funded AAA R01 "identifying epidemiological risk factors for abdominal aortic aneurysm" established one of the few large population-based prospective US cohorts to identify etiologic risk factors for incident AAA. Among 15,792 aric participants followed for more than two decades, we ascertained 665 aaas, identified novel middle-age risk markers for AAA, and estimated the lifetime risk for AAA from age 45 to be 5.6%. Building upon our original R01 and an ongoing proteomic project in aric, we propose a 4-year study to identify proteomics risk markers and investigate novel mechanisms and etiological pathways for AAA. Our specific aims are to: (1) leverage a large panel of aptamer-based, plasma proteomics data (n=4,931 human proteins) in the entire aric cohort from visits 2 and 3, to conduct a prospective study of proteomic risk markers for AAA (n=552 cases) over 24 years of follow-up, and to replicate significant proteins identified in nested AAA case (n=518)-cohort (n=833) samples from the prospective, population-based HUNT3 and sccs studies. We will use a combination of targeted and agnostic approaches. To ensure the accuracy and generalizability of our findings, we will also identify commercial assays or develop targeted quantitative liquid chromatography-mass spectrometry assays for the top 5 novel, replicated, aptameric-based proteins and then compare the targeted protein levels with the aptamer-based measurements in 200 aric plasma samples. (2) conduct genome-wide association study (gwas) in aric for proteins identified and replicated in aim 1, and replicate any significant genetic associations in HUNT3 (n=4,230), mesa (n=5,351), and published protein gwas database. We will also conduct a mendelian randomization study, incorporating data from the international AAA gwas consortium (10,204 aaas and 107,766 controls), to elucidate the causal relation between significant protein biomarkers and AAA, followed by a network analysis to integrate the genomic and proteomic findings. This study will use unsurpassed proteomic resource in aric and other cohorts to identify new risk factors and mediators of AAA, with potential implications for AAA prevention and treatment.

Transactions

Action Federal Non-federal Date
Amendment $0 $0
Amendment $0 $0
Amendment $487,254 $0
Amendment $679,197 $0
Amendment $679,197 $0
Amendment $1,161,456 $0
Amendment $1,161,456 $1,161,456
Amendment $814,292 $0
Original award $814,292 $814,292

Subawards

Subrecipient Amount Awarded
The Johns Hopkins University Identifying Proteomics Risk Markers for Abdominal Aortic Aneurysm $266,894
University Of Texas Health Science Center At Houston $295,846
Vanderbilt University Medical Center $321,363
Baylor College Of Medicine $416,238
Norges Teknisk-Naturvitenskapelige Universitet Ntnu $65,815
Baylor College Of Medicine $371,404
University Of Texas Health Science Center At Houston $209,906
Vanderbilt University Medical Center $301,558
The Regents Of The University Of California. San Francisco Identifying Proteomics Risk Markers for Abdominal Aortic Anueurysm $66,493
Baylor College Of Medicine Identifying Proteomics Risk Markers for Abdominal Aortic Aneurysm $183,582
Norges Teknisk-Naturvitenskapelige Universitet Ntnu $61,495
The Johns Hopkins University $195,059
Show all 12

Quick answers

Who received award R01HL155209?

R01HL155209 was awarded to Regents Of The University Of Minnesota by National Heart Lung and Blood Institute (National Institutes of Health) on July 15, 2021.

How much is award R01HL155209 worth?

$7,772,892 has been obligated on R01HL155209: $5,797,144 in federal funding and $1,975,748 in non-federal funding.

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