Project Grant R01EY038208
- The National Eye Institute awarded The Johns Hopkins University $776,269 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop and externally validate critical elements of a clinical decision support system (CDSS) that optimizes treatment selection for glaucoma patients experiencing rapid visual field deterioration. The project addresses a treatment gap: randomized controlled trials demonstrate that non-medical interventions (surgery or laser trabeculoplasty) produce less...
- The National Eye Institute, part of the National Institutes of Health within the Department of Health and Human Services, awarded Creighton University $350,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support discovery and development of novel trifunctional hybrid compounds for glaucoma therapy. The funded research focuses on designing and evaluating trifunctional hybrid compounds that integrate three disease-modifying entities—an FP...
- The National Eye Institute of the Department of Health and Human Services awarded $571,206 to the University of Maryland, Baltimore on May 1, 2026, under the Vision Research program (CFDA 93.867) to develop, refine, and validate sensitive and robust adaptive optics-optical coherence tomography (AO-OCT) biomarkers for glaucoma detection and progression monitoring. The project addresses the need for earlier detection of glaucoma progression and mechanistically relevant biomarkers to support...
- The National Eye Institute awarded The Johns Hopkins University $698,999 on July 1, 2026, under the Vision Research program (CFDA 93.867) to conduct research on mechanisms of functional retinal engraftment by transplanted retinal ganglion cells for optic neuropathies including glaucoma. The project addresses the death of retinal ganglion cells (RGCs), which transmit visual information from the eye to the brain. While existing treatments slow vision loss in some progressive optic neuropathies, no...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The Johns Hopkins University $148,062 on January 23, 2026, under the Vision Research program (CFDA 93.867) to conduct research on pathway-specific eligibility traces in reinforced cortical learning. The recipient will use electrophysiology to test whether eligibility traces—transient synaptic tags that enable learning through delayed reinforcement—are restricted to specific...
- The National Eye Institute awarded The Johns Hopkins University $427,504 on July 1, 2026, under the Vision Research program (CFDA 93.867) to develop BLAB-SEQ, a non-toxic, transgene-based method that combines fluorescent birth dating with single-cell RNA sequencing to determine birth dates and transcriptomic profiles of neuronal subtypes in human organoids. The project will integrate birth-labeled sequencing with multiomics analysis to directly link neuronal birth timing and fate...
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
- The National Eye Institute awarded The Trustees of Columbia University in the City of New York $532,079 on September 1, 2026, under the Vision Research program (CFDA 93.867) to characterize the role of apelin signaling in Schlemm's canal development and its relationship to early-onset glaucoma. The research employs mouse models to express and trace the apelin receptor during Schlemm's canal development, uses conditional and inducible mouse models to study loss of apelin receptor function...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $2.085 million under the Vision Research program (CFDA 93.867) on September 30, 2025, to investigate cholinergic dysfunction in glaucoma using advanced magnetic resonance imaging and spectroscopy techniques. The research tests the hypothesis that glaucoma is driven by impairments of the visual pathways mediated by the cholinergic nervous...
- The National Eye Institute awarded the Regents of the University of Minnesota $764,310 on July 1, 2026, under the Vision Research program (CFDA 93.867) to develop robust multimodal artificial intelligence models for primary open-angle glaucoma prognosis. The recipient will develop deep learning models that integrate longitudinal data from fundus images, optical coherence tomography, visual fields, and structured clinical variables to estimate individual likelihood of developing primary...
The National Eye Institute awarded The Johns Hopkins University $624,689 under the Vision Research program (CFDA 93.867) on September 1, 2026, to develop machine learning-driven peptide engineering for sustained intraocular pressure lowering in glaucoma treatment. The research applies artificial intelligence methodology adapted from the super learning approach to engineer multifunctional peptides that bind to melanin, enter cells efficiently, and exhibit low cytotoxicity. High-throughput screening combined with the super learning model identified 780 peptides that outperformed literature-reported candidates. A 12-mer peptide conjugated to brimonidine—currently available as a topical drop requiring three-times-daily administration—achieved intraocular pressure lowering for up to 18 days with a single injection. The project will use the high-throughput screening and super learning methodology to further improve the physicochemical properties of engineered peptides, targeting sustained drug delivery to overcome poor patient adherence to eye drop regimens and enable effective long-term glaucoma treatment. Performance is located in Baltimore, Maryland, with a period of performance from September 1, 2026, through August 31, 2030. The award is classified as a Project Grant under the assistance type structure.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $624.7k | 8/31/26 |