Gears combining advances in genomics and environmental science to accelerate actionable research and practice in ASD
Active Project Grant Awarded Last action
- Award ID
- R01ES034554
- Recipient
-
The Johns Hopkins University UEI FTMTDMBR29C7
- Awarding agency
-
National Institute of Environmental Health Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $8,102,322
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date 69% complete
- Originally
- Funding agency
- National Institute of Neurological Disorders and Stroke National Institutes of Health, Department of Health and Human Services
- Place of performance
- Baltimore, MD 21218, USA
Award details come from USAspending.gov.
Description
- Abstract
- This application seeks to establish a network for the investigation of gene-environment interaction in autism spectrum disorder (ASD) and outcomes among people with ASD. Much like the psychiatric genetics consortium launched a unifying infrastructure for scaling genome-wide association studies in ASD, the combining advances in genomics and environmental science to accelerate actionable research and practice in ASD (gears) network effort will allow a centralized mechanism for GXE activities in ASD across multiple studies. Robust evaluation of GXE requires a large sample size, harmonized data on both genetics and the environment, and novel statistical methods for measuring and summarizing environments, genetics, and phenotypes. The gears network seeks to compliment work in population studies with experimental models leveraging 3D brain organoids, reflecting multiple ASD-associated genetics backgrounds on which the impact of environmental risk can be evaluated on ASD-relevant neurophysiology endpoints. Finally, the gears network will develop and implement a pipeline for outreach and dissemination of GXE findings. The successes of ASD genomics, emerging environmental evidence, and models of effective network collaborations for large-scale efforts make this the ideal time to create a GXE infrastructure for ASD research. Our team is uniquely poised to lead the gears network, creating this opportunity at scale for the first time, and with a focus on both etiology and health outcomes among people with ASD. We have experience in leading multi-site collaborations, expertise in population and laboratory science, and required partnerships to foster communication across researchers and with the broader ASD community. This translational approach, informed by public health, will lead to improved understanding of both causes and consequences of ASD.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $297,685 | |
| Amendment | $400,000 | |
| Amendment | $1,598,581 | |
| Amendment | $1,634,410 | |
| Amendment | $400,000 | |
| Amendment | $1,760,823 | |
| Amendment | $250,000 | |
| Original award | $1,760,823 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Drexel University | $358,317 | |
| Hugo W. Moser Research Institute At Kennedy Krieger, Inc. | $405,000 | |
| Kaiser Foundation Hospitals | $772,951 | |
| University Of California, Davis | $465,610 | |
| Holland Bloorview Kids Rehabilitation Hospital | $324,000 | |
| Aarhus Universitet | $323,180 |
Quick answers
Who received award R01ES034554?
R01ES034554 was awarded to The Johns Hopkins University by National Institute of Environmental Health Sciences (National Institutes of Health) on September 6, 2022.
How much is award R01ES034554 worth?
$8,102,322 has been obligated on R01ES034554.
Which agency awarded R01ES034554?
National Institute of Environmental Health Sciences (National Institutes of Health) awarded R01ES034554, with funding from National Institute of Neurological Disorders and Stroke (National Institutes of Health).
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