Optimizing a patient-specific regenerative larynx implant for restoration of voice
Active Project Grant Awarded Last action
- Award ID
- R01DC019114
- Recipient
-
Mayo Clinic Arizona UEI ULMJJBL7ZXX3 Part of Mayo Collaborative Services, Inc.
- Awarding agency
-
National Institute on Deafness and Other Communincation Disorders
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,935,438
Award facts
- Assistance listing
- 93.173 Research Related to Deafness and Communication Disorders
- Completion date 86% complete
- Originally
- Funding
-
- $4,321,727.00 Federal
- $613,711.00 Non-federal
- Place of performance
- Scottsdale, AZ 85259, USA
Award details come from USAspending.gov.
Description
- Abstract
- The larynx governs our most basic life-sustaining functions and serves as the foundation of our self-identity. Even the most minor aberration within this delicate and complex structure can result in life-altering or life- ending consequences. The ability to breathe, swallow, and voice are all regulated by the larynx. Even though these functions can be replaced with various tubes and prosthetics, they cannot replace the normal human experience. Patients state that losing their voice feels like losing their identity. They wish to talk with their own voice again, sing to their children, and have a meal with their families. Coughing mucus out of a tracheostomy tube, feeding one's self through a stomach tube, and speaking like a robot are embarrassing, leading most to live a life of social isolation. Development of a bioengineered patient-specific implant can restore all three laryngeal functions and improve healing, thereby saving lives and improving quality-of-life. The goal of our project is to optimize a process and a product to restore all three laryngeal functions -- breathing, swallowing, and voice -- with a patient-specific, immobile hemilarynx implant that obviates the need for revision surgery, improves healing, and enhances implant integration. To achieve our goal we will complete the following 3 aims: aim 1: to refine the design process for a patient-specific implant shape, we will quantify voicing, breathing, and swallowing of excised larynges tested with different patient-specific implants. Aim 2: to optimize laryngeal wound healing without the muscle flap, we will evaluate flat scaffold patches with cellular and acellular components in an in vivo model of a laryngeal mucosal wound. Aim 3: to evaluate the performance of the bioengineered implant in a long-term in vivo hemilarynx reconstruction model, we will assess immune response, tissue integration, epithelial development, and function -- voicing, breathing, and swallowing -- with canine-specific implants with both optimal shape and optimal cellular and acellular components.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $628,870 | $0 | |
| Amendment | $629,671 | $0 | |
| Amendment | $559,922 | $0 | |
| Amendment | $637,921 | $0 | |
| Amendment | $637,921 | $0 | |
| Amendment | $613,711 | $0 | |
| Original award | $613,711 | $613,711 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Midwestern University | $13,686 |
Quick answers
Who received award R01DC019114?
R01DC019114 was awarded to Mayo Clinic Arizona by National Institute on Deafness and Other Communincation Disorders (National Institutes of Health) on September 1, 2021.
How much is award R01DC019114 worth?
$4,935,438 has been obligated on R01DC019114: $4,321,727 in federal funding and $613,711 in non-federal funding.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award