Route 66 endometrial cancer spore

Active Project Grant Awarded Last action

Award ID
P50CA265793
Recipient
Awarding agency
Obligated
$9,858,971

Award facts

Assistance listing
93.397 Cancer Centers Support Grants
Completion date 64% complete
Place of performance
St. Louis, MO 63110, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The route 66 endometrial cancer spore brings together interactive research teams from three institutions to create a dynamic translational research program aimed at developing and testing new strategies to prevent and treat endometrial cancer. This spore includes three research projects; an administrative core; a biostatistics and bioinformatics core; a biospecimens, metabolomics, and pathology core; and developmental research and career enhancement programs. The three projects, chosen and refined with extensive input from our internal and external advisory boards, are designed to have significant potential to change clinical practice within five years. Project 1: hspa proteins in advanced and recurrent endometrial cancer therapy. Project 2: inhibiting AXL to improve treatment response in endometrial cancer. Project 3: improving primary prevention and uterine preservation in premenopausal women with obesity and endometrial hyperplasia. Projects 1 and 2 are clinical/translational projects, whereas project 3 is an early detection, prevention, or population science project. All three projects include clinical trials and represent carefully chosen marriages between selected endometrial cancer research priorities and the strengths of washington university in ST. Louis and our collaborators at the university of new mexico and the university of oklahoma health sciences center. The overall aims of our spore are to 1) test promising new therapies to treat or prevent endometrial cancer; 2) elucidate the key biologic processes that drive endometrial cancer and develop novel biomarkers to predict development of endometrial cancer and response to therapies; 3) leverage and enhance capacities of shared research resources; 4) recruit and mentor new investigators and support innovative ideas in translational endometrial cancer research; 5) facilitate collaboration of those interested in endometrial cancer research; and 6) ensure equitable enrollment in clinical trials and involvement of diverse community members and investigators in research. In completing the work proposed here, we will test three new strategies to prevent or treat endometrial cancer. Future work can be directed at moving the most promising treatment approaches into larger trials. Additionally, we will obtain an unprecedented level of molecular, cellular, immunologic, and metabolomic detail regarding endometrial cancer and response to treatment, which will likely lead to development of additional novel clinical trials. Finally, by developing new ideas, investigators, and collaborations, we will expand the breadth and depth of research aimed at treating or preventing endometrial cancer.

Transactions

Action Obligated Date
Amendment $1,700,196
Amendment Route 66 endometrial cancer spore - the route 66 endometrial cancer spore brings together interactive research teams from three institutions to create a dynamic… $2,581,832
Amendment $749,771
Amendment $194,375
Amendment $2,248,055
Original award $2,384,742

Subawards

Subrecipient Amount Awarded
University Of Nebraska Medical Center Symptomatic osteoarthritis (OA) is a common cause of pain and disability, affecting 32 million adults in the U.S., with anticipated rises in incidence due to… $17,049
Barnes Jewish Hospital Scope of Work Project Title: Route 66 Endometrial Cancer SPORE Subrecipient PI and Institution: Dr. David Morris, Barnes-Jewish Hospital Up to 90% of the… $26,879
Icahn School Of Medicine At Mount Sinai SCOPE OF WORK ISMMS PDX Supplement Specific Aims: We hypothesize that autologous humanized PDX models will represent the heterogeneous response to combined… $98,165
University Of New Mexico SCOPE OF WORK University of New Mexico PDX Supplement Dr. Steinkamp’s lab will be involved in all aims. During this year, we propose to collect samples from… $320,078
University Of New Mexico Obesity is a major risk factor for endometrial cancer, and glucagon like peptide-1 receptor (GLP-1R) agonists such as semaglutide offer an effective weight loss… $424,205
University Of Oklahoma SCOPE OF WORK – Administrative Core The Route 66 Endometrial Cancer Specialized Program of Research Excellence (SPORE) brings together established experts in… $481,863
The Regents Of The University Of California. San Francisco SCOPE OF WORK – Administrative Core The Route 66 Endometrial Cancer Specialized Program of Research Excellence (SPORE) brings together established experts in… $296,333
The Research Foundation For The State University Of New York Scope of Work The incidence and mortality of endometrial cancer has increased over the past few decades, and is predicted to continue rising. There is… $61,697
Icahn School Of Medicine At Mount Sinai SCOPE OF WORK ISMMS Supplement # 3P50CA265793-02S1 Induced pluripotent stem cells derived from patients can be differentiated towards immune cell lineages,… $311,832
University Of New Mexico SCOPE OF WORK University of New Mexico Supplement # 3P50CA265793-02S1 Mortality from endometrial cancer is rising and there is an important need for… $303,319
The Regents Of The University Of California. San Francisco SCOPE OF WORK – Administrative Core The Route 66 Endometrial Cancer Specialized Program of Research Excellence (SPORE) brings together established… $409,795
Barnes Jewish Hospital Scope of Work Project Title: Route 66 Endometrial Cancer SPORE Subrecipient PI and Institution: Dr. David Morris, Barnes-Jewish Hospital Up to 90% of the… $25,931
The Research Foundation For The State University Of New York Scope of Work The incidence and mortality of endometrial cancer has increased over the past few decades, and is predicted to continue rising. There is… $51,766
University Of Oklahoma SCOPE OF WORK – Administrative Core The Route 66 Endometrial Cancer Specialized Program of Research Excellence (SPORE) brings together established… $97,875
Barnes Jewish Hospital Scope of Work Up to 90% of the ~65,000 women diagnosed with endometrial cancer each year in the U.S. are overweight or obese, and up to 60% of endometrial… $318
University Of New Mexico SCOPE OF WORK – Administrative Core The Route 66 Endometrial Cancer Specialized Program of Research Excellence (SPORE) brings together established… $49,562
Show all 16

Quick answers

Who received award P50CA265793?

P50CA265793 was awarded to The Washington University by National Cancer Institute (National Institutes of Health) on August 23, 2023.

How much is award P50CA265793 worth?

$9,858,971 has been obligated on P50CA265793.

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