The indiana university-ohio state university maternal and pediatric precision in therapeutics data, model, knowledge, and research coordination center (IU-OSU mprint dmkrcc)

Active Project Grant Awarded Last action

Award ID
P30HD106451
Recipient
Awarding agency
Obligated
$46,935,036

Award facts

Assistance listing
93.310 Trans-NIH Research Support
Completion date 85% complete
Originally
Funding
  • $43,935,038.00 Federal
  • $2,999,998.00 Non-federal
Funding agency
Office of the Director National Institutes of Health, Department of Health and Human Services
Place of performance
Indianapolis, IN 46202, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Early-onset, or preterm, preeclampsia occurs in only 0.5% of pregnancies, but IT is associated with a high risk of long- term maternal complications, as well as high fetal morbidity and mortality. Biomarkers associated with early-onset preeclampsia are needed to identify women at risk of developing early-onset preeclampsia, guide treatment options, and support development of new therapeutic approaches to prevent and treat the disease. Additionally, IT is important to understand the long-term consequences of preterm preeclampsia in both the mother and child. However, due to the low incidence of early-onset preeclampsia, IT is difficult to obtain data and necessary biospecimens from a sufficient number of women through a single center or study. Whether collected as a prospective biobanking endeavor or leftover residual samples from clinical studies, numerous biospecimens from maternal and pediatric patients reside within storage facilities across the world. These untapped biosamples and their associated data have the potential to greatly enhance maternal and pediatric therapeutics research, especially for rare conditions and diseases such as early-onset preeclampsia. However, there is no single resource to identify sources of maternal and pediatric biospecimens, so often translational researchers seeking such samples may not be aware of their existence. This proposal will characterize the landscape of available maternal and pediatric biospecimens and survey investigators to understand the needs of the translational research community. We will develop the collaborative online perinatal & pediatric repository (copper), a user-friendly platform to facilitate identification of biobanks and networks with residual biospecimens available to support maternal and pediatric precision therapy research. Through surveys and working group discussions, we will seek to understand the evolution of regulations relating to future use of biospecimens and propose strategies to enhance the ability to link long-term pediatric outcomes to samples collected during the perinatal period. At the end of this project, we will develop a centralized resource providing information on biorepositories which could support maternal and pediatric translational research and precision therapeutics, develop proposals to enhance the ability to link maternal and child data and specimens, and identify biospecimens and associated clinical data to support future work to develop biomarkers and therapeutic approaches to prevent and treat early-onset preeclampsia.

Transactions

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Subawards

Subrecipient Amount Awarded
Whitby Et AL, LLC The MPRINT Modeling Support (MMS) team will extend and enhance the MPRINT Knowledge Portal on three fronts, by: (Aim 1) developing and populating a Modeling… $149,930
Childrens Mercy Hospital Many medicines are made with fluorine in their molecular structure. This helps them work better in the body and last longer. About 20% of medicines today have… $150,000
Chapman University Vitamin D and its metabolites are essential for bone growth, metabolic regulation, and immune system development. Children with cancer may be particularly… $150,000
Research Institute At Nationwide Children's Hospital Dr. Christopher Bartlett and Dr. Carl Backes will lead the team at the Nationwide Children's Hospital to support the following scope of work for "The Indiana… $621,807
Childrens Hospital Medical Center Dr. Mendonca will work in collaboration with Drs. Grannis (Indiana University/Regenstrief Institute) and Bartlett (Nationwide Children’s Hospital) to… $20,970
The Research Foundation For The State University Of New York Drs. Bies and Shah will work in conjunction with the research assistant to support population PK, PBPK-PD modeling for MPRINT network members assisting in the… $1,007,098
Regenstrief Institute Inc. For this project, assigned personnel from the Center for Biomedical Informatics and the Research Data Services team will support the project management, data… $241,484
The Ohio State University The Ohio State University (OSU) team will be led by Dr. Lang Li, one of the two MPIs in this proposal, Indiana University-Ohio State University Maternal and… $3,909,825
Purdue University The Pharmacometrics and Clinical Trial Design core (PCTDC) of the Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics… $328,295
Purdue University The Pharmacometrics and Clinical Trial Design core (PCTDC) of the Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics… $3,627
Vanderbilt University ABSTRACT Inflammatory bowel disease (IBD) is a chronic, refractory condition affecting the gastrointestinal tract, and it includes both Crohn's disease and… $150,000
The Ohio State University The Ohio State University (OSU) team will be led by Dr. Lang Li, one of the two MPIs in this proposal, Indiana University-Ohio State University Maternal and… $255,674
The Ohio State University $1,099,889
The Ohio State University The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU… $818,365
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Quick answers

Who received award P30HD106451?

P30HD106451 was awarded to Trustees Of Indiana University by National Institute of Child Health and Human Development (National Institutes of Health) on May 1, 2022.

How much is award P30HD106451 worth?

$46,935,036 has been obligated on P30HD106451: $43,935,038 in federal funding and $2,999,998 in non-federal funding.

Which agency awarded P30HD106451?

National Institute of Child Health and Human Development (National Institutes of Health) awarded P30HD106451, with funding from Office of the Director (National Institutes of Health).

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