This K23 Project Grant, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), provides $389,880 to develop and test a set of behavioral economics and financial incentive-based strategies to improve treatment engagement, medication adherence, and substance avoidance for patients transitioning from Coordinated Specialty Care (CSC) for first-episode psychosis to post-CSC care. The research aims to assess barriers and facilitators to...
This Project Grant award in the amount of $2,005,780.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to develop digital strategies to advance help-seeking in youth at clinical high risk for developing psychosis. The key objectives of this project are to: 1) characterize help-seeking subtypes in 25,000 youth who screen positive for psychosis risk; 2) establish the most effective PQ-B threshold score for identifying...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $422,206 to the Research Foundation of the City University of New York (RFCUNY) to develop and pilot test a psychosocial intervention for sexual and gender minority autistic adults. The objective is to address the lack of available evidence-based interventions for this population, who face increased mental health risks. The project, titled...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under CFDA Program 93.242 Mental Health Research Grants, provides $3,412,446 to the University of Maryland, Baltimore to harness a two-state learning healthcare system and early psychosis intervention network to optimize engagement and prevent disengagement in coordinated specialty care (CSC) for youth with first episode psychosis. The project will leverage the Connection Learning Healthcare System (CLHS) to...
This $1,200,000 Project Grant award from the Substance Abuse and Mental Health Services Administration (SAMHSA) under the Substance Abuse and Mental Health Services Projects of Regional and National Significance (CFDA 93.243) program will fund the Suffolk County Community Treatment and Service (SCCTS) Center. The SCCTS Center, operated by the non-profit Federation of Organizations, will increase access to effective trauma- and grief-focused treatment and support services for children and...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $388,800 to The Trustees of Columbia University in the City of New York to conduct research on autism spectrum disorder (ASD) and its connections to schizophrenia (SCZ). The research will evaluate cognitive systems and psychopathology in autistic individuals who carry rare genetic variants associated with both ASD and SCZ. Specifically, the study...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) totaling $693,476 will fund a study to evaluate the long-term sustainment of an evidence-based health promotion intervention called INSHAPE for adults with serious and disabling mental illness (SMI). The study aims to examine two key dimensions of sustainment: 1) sustained delivery of the INSHAPE program, and 2) sustained health benefits of the program. The...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,217,886 to The Feinstein Institutes for Medical Research to conduct a multi-center, randomized clinical trial. The goal is to develop a decision support tool that uses biomarkers to guide the use of clozapine, an effective but high-risk antipsychotic medication, for patients experiencing their first episode of psychosis. The study will...
This $2,805,764 Project Grant award from the Substance Abuse and Mental Health Services Administration (SAMHSA) under the Assisted Outpatient Treatment (AOT) Program (CFDA 93.997) aims to develop and operationalize a replicable structure to increase the utilization of AOT as a step-down transition from inpatient to community-based mental health care in Illinois. The award recipient, the Administrative Office of the Illinois Courts (AOIC), will establish local project teams in Cook and McLean...
The University of Pittsburgh is conducting a $420,685 project grant titled "Accelerated Neuromodulation of Prefrontal Circuitry During Clozapine Treatment" funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). This two-year project seeks to explore the use of accelerated intermittent theta burst stimulation (iTBS) to enhance working memory and functional connectivity in individuals with treatment-resistant...
LEARNING TO LIVE INDEPENDENTLY FOR TOMORROW (LIFT) - SCHIZOPHRENIA AFFECTS 1% OF THE POPULATION, CAUSING ENORMOUS SUFFERING, DISABILITY, AND SUBSTANTIAL SOCIETAL COSTS. TIMELY ENGAGEMENT IN CSC FOR YOUTH WITH FIRST EPISODE PSYCHOSIS (FEP) IS CRITICAL TO IMPROVE OUTCOMES AND SUPPORT FUNCTIONAL AND SYMPTOMATIC RECOVERY. IN NEW YORK STATE (NYS), OTNY HAS ESTABLISHED A UNIFIED APPROACH TO DELIVERING CSC TO ADOLESCENTS AND YOUNG ADULTS WITH FEP. SINCE INCEPTION, 27 OTNY PROGRAMS HAVE BEEN DEVELOPED ACROSS NYS, INCLUDING 13 IN OUR CATCHMENT AREA OF MANHATTAN, QUEENS, BROOKLYN, AND LONG ISLAND, PROVIDING CSC TO OVER 3,000 YOUTH STATEWIDE TO DATE. DIRECTED BY DR. BIRNBAUM, THE OTNY PROGRAM AT ZHH IS THE LARGEST AND MOST ESTABLISHED AND HAS PROVIDED CARE TO OVER 300 YOUTH. HOWEVER, EARLY INTERVENTION SERVICES ARE TIME LIMITED. OTNY PROGRAMS ARE DESIGNED AND RESOURCED TO PROVIDE CSC FOR APPROXIMATELY 2 YEARS, AFTER WHICH, DISCHARGED PATIENTS (75% BETWEEN THE AGES OF 16-25 YEARS) ARE USUALLY REFERRED TO STANDARD CLINICAL CARE WITHIN THE COMMUNITY. CRITICALLY, ACCUMULATING EVIDENCE DEMONSTRATES THAT THE BENEFITS OF EARLY INTERVENTION OBTAINED DURING CSC DO NOT PERSIST POST DISCHARGE AFTER TRANSITIONING TO STANDARD CARE. FURTHER, THE RISK OF DISENGAGEMENT IS HEIGHTENED DURING THE TRANSITION FROM CSC TO STANDARD CARE, INCREASING RISK FOR MEDICATION NON-ADHERENCE, SYMPTOMATIC RELAPSE, SOCIAL ISOLATION, UNEMPLOYMENT, AND SUBSTANCE USE. DATA ALSO SUGGEST THAT MINORITY POPULATIONS MAY BE PARTICULARLY SUSCEPTIBLE TO NEGATIVE OUTCOMES POST-CSC DISCHARGE. MOREOVER, YOUTH GRADUATING OTNY HAVE NEW CLINICAL AND DEVELOPMENTAL NEEDS AS THEY MATURE INTO YOUNG ADULTS (AND GAIN GREATER INDEPENDENCE) THAT REQUIRE DEDICATED SUPPORTS YET RECEIVE INSUFFICIENT ATTENTION IN STANDARD CLINICAL CARE. DESPITE A CLEAR NEED, EFFECTIVE CARE FOR YOUTH GRADUATING OTNY ARE LACKING, RESULTING IN REPEATED CALLS FOR INNOVATIVE SOLUTIONS DESIGNED TO SUSTAIN GAINS AND PROMOTE ONGOING RECOVERY. TO ADDRESS THIS CRITICAL SERVICE GAP, NORTHWELL HEALTH, IN PARTNERSHIP WITH THE NYS OFFICE OF MENTAL HEALTH (OMH), IS PROPOSING TO DEVELOP A CSC STEP-DOWN SERVICE AT ZHH FOR YOUTH AGES 16-25 GRADUATING FROM ZHH'S OTNY SITE AS WELL AS THOSE REFERRED BY OTHER LOCAL OTNY SITES. LEVERAGING OUR ESTABLISHED EXPERTISE IN RECOVERY ORIENTED CARE, THE LIFT TEAM WILL PROVIDE EVIDENCE-BASED AND COORDINATED SUPPORTS, USING THE CRITICAL TIME INTERVENTION (CTI) MODEL DESIGNED TO BE INTEGRATED AND DELIVERED IN CONJUNCTION WITH STANDARD CARE, AIMING TO 1) EXTEND AND ENHANCE THE BENEFITS OF EARLY INTERVENTION, 2) MINIMIZE DISENGAGEMENT DURING A CRITICAL TIME OF TRANSITION (OTNY GRADUATION), AND 3) EQUIP YOUTH WITH THE SKILLS AND RESOURCES THEY NEED TO FOSTER AUTONOMY, INDEPENDENCE, AND TO LEAD PRODUCTIVE AND FULFILLING LIVES.