Project Grant F31CA314111
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $399,129 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on July 15, 2025, with a completion date of June 30, 2027. This award supports research to develop and evaluate improved cancer treatment methods through laboratory and clinical investigation. Specifically, the research leverages a DDX3 inhibitor called RK-33 to alter the metabolic tumor environment in...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $246,660 Project Grant under the Cancer Research Manpower program (CFDA 93.398) on December 27, 2025, with a completion date of June 30, 2028. This award supports Dr. Komatsu's laboratory in conducting translational research to visualize and characterize B cell infiltration and aggregation within the tumor microenvironment. The research employs transgenic mouse models with dorsal skin...
- Federal Project Grant Award Summary The University of Florida Division of Sponsored Research received a $502,391 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) effective July 1, 2026, through June 30, 2031. This award supports the development and preclinical evaluation of RNA-loaded lipid nanoparticle aggregates (RNA-LPAs) as a novel mRNA vaccine platform for glioblastoma treatment. The research delivers an innovative...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a Project Grant totaling $658,423 under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2026 through June 30, 2031. This award supports fundamental research on therapeutic targeting of PI3K gamma (PI3Kγ)-positive tumor-associated macrophages (TAMs) in metastatic castration-resistant prostate cancer (MCRPC) to reduce health disparities. The research builds on the investigator...
- Federal Project Grant Award Summary The University of Massachusetts received a $832,936 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective June 26, 2026, through May 31, 2031. The grant supports development of a novel dual-adjuvant, dual-delivery nanoparticle (NP) cancer vaccine platform designed to overcome critical barriers in cancer immunotherapy. The research centers on a "prime-pull" vaccination...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded The Johns Hopkins University a $598,859 Project Grant effective June 1, 2026 through May 31, 2029 under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award supports the development of Antigen-Presentation Modulating Nanoparticles (APM-NPs), a novel immune engineering platform technology designed to enhance T cell...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Johns Hopkins University a $144,193 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective September 4, 2025 through August 31, 2030. This award provides protected salary support for Dr. Preethi Korangath to serve as a Laboratory Research Specialist in Dr. Robert Ivkov's laboratory, where she will facilitate the completion of Research Project Grants (R01) by leveraging her expertise...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $155,479 Project Grant (CFDA 93.395, Cancer Treatment Research) effective June 1, 2026 through May 31, 2028 to develop and validate an anti-CCRL2 (C-C motif receptor-like 2) antibody-drug conjugate (ADC) for treating high-risk myelodysplastic syndrome (MDS) and MDS-related acute myeloid leukemia (AML), particularly in patients with TP53 mutations. The research deliverables include preclinical...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Johns Hopkins University a project grant of $109,076 under the Cancer Research Manpower program (CFDA 93.398) on January 16, 2026, with a completion date of July 31, 2028. This award funds research investigating the role of acetyl-coenzyme A synthetase 2 (ACSS2) in T cell adaptation to metabolic stress within tumor microenvironments. The research addresses a critical gap in understanding how T cells survive and...
- This $131,220 Project Grant from the National Cancer Institute, part of the Department of Health and Human Services, will support cancer vaccine research under the Cancer Research Manpower federal grant program (CFDA 93.398). The grant recipient, Stanford University, will develop a new approach to cancer vaccination that directly reprograms cancer cells into antigen presenting cells (APCs) through mRNA-enabled cell reprogramming. Researchers aim to overcome barriers to current vaccination...
The National Cancer Institute awarded a $100,228 Project Grant to The Johns Hopkins University under the Cancer Research Manpower program (CFDA 93.398) for research on mRNA-lipid nanoparticle (LNP) vaccine development for cancer immunotherapy. The grant, effective December 1, 2026 through November 30, 2029, supports research to engineer composition-optimized mRNA-LNPs capable of directing systemic delivery to vital organs such as the liver and lungs, where metastatic cancers commonly occur. The research aims to overcome current limitations of existing mRNA-LNP vaccine platforms, which predominantly prime immune responses at the injection site and draining lymph nodes rather than generating localized, tissue-specific immunity within target organs. The grant funds development and characterization of rational LNP design strategies to promote recruitment and formation of tissue-resident memory T cells within systemic organs, a critical objective for achieving durable tumor control and long-term antitumor activity. Research activities will include engineering LNPs that escape the injection site, defining design rules for future vaccine development by characterizing how LNP composition influences trafficking and antigen expression dynamics, and correlating immune activation and memory formation with both therapeutic and prophylactic efficacy outcomes. This research addresses a significant unmet need in cancer immunotherapy by leveraging mRNA-LNP platform innovations to enable targeted, organ-specific cancer vaccine development.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 6/9/26 | ||
| Not listed | $50.1k | 6/9/26 | ||
| Not listed | $50.1k | 6/9/26 |