Project Grant DP2NS155519
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $164,000 on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds research into the role of T cell receptor alpha (TRAC) signaling in regulatory T cells' pain-suppressive function. The project investigates how TRAC-mediated signaling regulates neuropathic pain and aims to identify new therapeutic targets and biomarkers for...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $1,179,715 on March 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to understand how nociceptors—somatosensory nerve fibers that detect noxious stimuli—detect, integrate, and transmit pain signals under various environmental and physiological conditions. The recipient will...
- This $2,249,392 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to validate senescent cells as a target for the treatment of chronic pain in aging. The project aims to rigorously characterize the role of senescent neurons and their senescence-associated secretory phenotype (SASP) in driving dorsal root ganglion hyperexcitability and persistent pain following...
- The National Institute on Drug Abuse awarded the Regents of the University of California, San Francisco $219,526 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) for a Project Grant (R21DA065898) focused on multimodal phenotyping to predict non-response and opioid risk in chronic low back pain. The research will develop predictive tools and phenotypic subgrouping models to support precision pain management in chronic low back pain, a major driver of...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a $246,000 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 1, 2025, with a completion date of August 31, 2027. This award funds research investigating pain mechanisms in the female reproductive tract, specifically examining serotonergic and purinergic signaling pathways that mediate...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke awarded a $4.04 million Project Grant to the University of Texas at Dallas for a three-year initiative (September 1, 2025 through August 31, 2028) to identify and validate therapeutic targets for chronic pain treatment. The project leverages a CRISPR-based functional genomic screening platform developed by collaborating researchers at the University of Sydney and an extensive human dorsal root ganglion...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $407,113 to the University of California, Irvine on August 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support development of novel KV7 channel modulators for pain therapy. This R21 exploratory research grant, which concludes July 31, 2027, will establish an empirical foundation for developing therapies targeting...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $445,049 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop membrane-inspired lipid nanoparticles for cell-type-specific expression of programmable RNA. The recipient will design novel lipid nanoparticle formulations to achieve precise, scalable delivery of biomolecules to specific cell types, combining bio-inspired...
- The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $423,500 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissociate neural representations of pain and salience using intracranial human brain recordings. The research will obtain intracranial electroencephalography (iEEG) measurements in 20 neurosurgical patients as they perform thermal pain and auditory...
The National Institutes of Health Office of the Director awarded The Regents of the University of California, San Francisco $779,000 on September 4, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop engineered T cells as programmable therapeutic delivery vehicles for chronic pain treatment. The research integrates immunology, neuroscience, and synthetic biology to reprogram regulatory T cells with synthetic receptors designed to home to dorsal root ganglia and detect pain-related signals. Upon sensing molecules selectively upregulated in chronic pain conditions, the cells will release anti-nociceptive peptides and cytokines, including enkephalin and IL-10, enabling spatial and temporal control of analgesic action while reducing systemic side effects and tolerance risk. The modular design permits future customization to other pain states or neural circuit disorders. Performance occurs in San Francisco, California, with a period of performance extending through August 31, 2031. This is a project grant, a standard assistance type under Trans-NIH Research Support, which covers multiple offices in the NIH Office of the Director offering assistance awards to domestic and foreign organizations, universities, hospitals, and other institutions based on scientific merit and program relevance.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $779.0k | 9/3/26 |