Genome technologies coordinating center

Active Cooperative Agreement Awarded Last action

Award ID
U24HG011735
Recipient
Awarding agency
Obligated
$22,671,408

Award facts

Assistance listing
93.172 Human Genome Research
Completion date 62% complete
Originally
Funding
  • $20,539,954.00 Federal
  • $2,131,454.00 Non-federal
Place of performance
Farmington, CT 06032, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The genome technology portfolio at nhgri encompasses a substantial diversity of scientific approaches and objectives, from instrumentation development to high-throughput application of technologies to characterizing the genomic basis for phenotypic traits. These research efforts have produced significant insight into biology and disease, and yet there are many opportunities to accelerate innovation, development, and early dissemination of genomic technologies. The goal of the genome technology coordinating center (gtcc) is to maximize these opportunities by liaising grantees and nhgri program staff, managing research funds, and developing educational resources to support and tout the excellence of the genome technology program. We propose the following aims to meet these goals: 1) facilitate collaborations across the genome technology program and promote standards that aid in achieving program goals. We will host and support annual meetings for the genome technology and cegs programs. We will also develop working groups among grantees to promote collaboration-building and the development of metrics and standards for genomic technologies. We will use these working groups to identify gaps in the field that will provide the foundation for solicitation of opportunity funds. 2) establish and manage an opportunity funds program to support initial development of promising new technologies and ideas. These opportunity funds will be distributed as pilot projects (early stage or proof-of- principle studies) and development projects (comparatively advanced studies with supportive preliminary data) in years 2-4. Peer review will be conducted by an external review panel of experts in genomic technology. 3) implement community outreach activities to encourage awareness of genome technology program successes and facilitate access by the scientific community. We will develop and manage an education and outreach working group composed of grantees and educational experts to identify and prioritize areas of development for educational materials, and host and advertise a website to distribute those materials. A targeted effort will be made to expose underrepresented and underserved populations in science to the advances and importance of the genome technology program. Informational resources related to technology transfer and intellectual property will be developed for grantees. The jackson laboratory (JAX) is uniquely qualified to serve as the gtcc for the genome technology program. The laboratory has over ninety years of history in supporting mammalian genetics research including through the provision of widely used information resources (e.g. mouse genome informatics) and educational programs including the annual short course on experimental models of human cancer (29 years), and the mckusick short course on human and mammalian genetics and genomics (nearly 60 years). The jackson laboratory for genomic medicine was established in 2012 to apply the lab's expertise in genomics and technology development toward improvements in genome-based medicine.

Transactions

Action Federal Non-federal Date
Amendment $0 $0
Amendment Technology development coordinating center - the nhgri genome technology program (GTP) encompasses a substantial diversity of scientific approaches and… $1,499,962 $0
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Amendment Technology development coordinating center $149,996 $0
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Amendment Technology development coordinating center $1,349,966 $0
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Amendment $1,498,134 $0
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Amendment $149,815 $0
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Amendment $1,348,319 $1,348,319
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Amendment $633,320 $0
Original award $633,320 $633,320
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Subawards

Subrecipient Amount Awarded
The Broad Institute, Inc. Here, we will establish a novel approach to nanoscale interaction genomics utilizing DNA-barcoded gold nanoparticles (AuNPs). These barcoded particles—which… $152,937
University Of Massachusetts The collaboration between the University of Massachusetts Amherst and Northeastern University takes advantage of highly complementary strengths, bringing the… $100,000
Brown University Brown University will lead the modeling, design, and experimental validation of a nanoscale ion source and its interface to a micro-electrostatic ion trap as… $100,000
The Trustees Of Columbia University In The City Of New York Dr. Chaolin Zhang is an Associate Professor in Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, and Motor Neuron Center at… $197,168
Northeastern University The Rouhanifard Lab at Northeastern University will be responsible for (1) transcriptome-wide identification of pseudouridine (ψ) modification sites using… $99,895
California Institute Of Technology Caltech will provide design, modeling, and analysis of a system comprising, in sequence: i) chip-based ion-field-emission (IFE) analyte ejectors, ii) a… $100,000
University Of Washington This project aims to develop a direct protein sequencing approach to detect post-translational modifications (PTMs) in activation and repression domains, with a… $99,998
University Of Illinois 1. Collaborate with researchers at the University of Massachusetts and Johns Hopkins University to design and perform molecular dynamics simulations of… $50,000
University Of Massachusetts The Chen group is experienced in protein engineering and single-channel measurement. The Chen lab will contribute to these areas: in Aim 1, we will test four… $49,949
The Leland Stanford Junior University This project aims to develop a direct protein sequencing approach based on nanopore sequencing to detect post-translational modifications (PTMs) in activation… $99,999
The Johns Hopkins University • We will synthesize proteins and purify defined chain lengths of poly(ADP-ribose) for the proposed nanopore experiments. • We will coordinate with the… $49,999
Fred Hutchinson Cancer Center This project aims to advance single-cell omics data analysis by improving metacell partitioning methods, addressing challenges such as data sparsity, signal… $200,000
The Regents Of The University Of California This project aims to develop a method for performing spatially resolved transcriptomic measurements of tissue slices with subcellular spatial resolution and… $200,000
The Research Foundation For The State University Of New York The overall project is to cross-validate our next generation mass spectrometry-based sequencing methods (NGMS-Seq) with next-generation sequencing (NGS)-based… $96,390
The University Of Chicago Dr. Pan’s group will be responsible for developing multi-modification targeted tRNA sequencing technology for most tRNA modifications. Our current… $103,610
University Of California, San Diego For this project, we (the Chavez lab) will develop a series of AAV-based tools to enable the selective tagging of genes within the brain of mice. For this work,… $150,000
Thomas Jefferson University In this work, the Hou lab will prepare both short and long RNAs and perform biochemical assays to correlate with solid-state analysis. The short RNAs will be… $76,500
Foundation For Applied Molecular Evolution, Inc. The Benner laboratory will work with the Boeke laboratory to address challenges in synthesizing long (>3000 bp) and ultra-long (chromosome length) DNA… $97,328
The Trustees Of The University Of Pennsylvania In this work, the Drndic lab will prepare solid-state nanopores and perform RNA translocation measurements through these nanopores. The molecules to be tested… $93,500
New York University The Boeke lab will produce the data described in Aim 2, namely to analyze how yeast manipulates AEGIS-containing fragments of DNA, in particular, how it… $102,669
The Broad Institute, Inc. A critical component of this technological workflow is the production of barcoded bead arrays, which enable spatially resolved RNA capture, or spatially… $198,408
University Of Washington We will first develop an mESC line with DNA Typewriter molecular recording machinery. We plan to capture transcriptomes along with barcoded Typewriter molecules… $110,367
University Of California, San Diego The Yeo lab will be responsible for transfection, lentivirus generation and transductions of cell lines, using plasmid constructs provided by the Kohli lab. The… $84,000
Yale Univ Dr. Liu will process samples on slides (samples that have been processed through the TempO-LINC hybridization assay steps and are provided by BioSpyder) through… $15,027
Biospyder Technologies, Inc. The goal of this program is to demonstrate the feasibility of adapting the pre-commercialization suspension single-cell targeted TempO-LINCâ„¢ gene… $145,770
The Trustees Of The University Of Pennsylvania The Kohli Lab and UPenn site will be responsible for the development and characterization of DNA deaminase enzyme variants with properties optimized for RNA… $84,000
The Research Foundation For The State University Of New York We propose to follow the reviewer’s recommendation and to carry out chemical ligation in parallel with the established method of splint ligation. Our… $140,837
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Quick answers

Who received award U24HG011735?

U24HG011735 was awarded to Jackson Laboratory by National Human Genome Research Institute (National Institutes of Health) on May 20, 2021.

How much is award U24HG011735 worth?

$22,671,408 has been obligated on U24HG011735: $20,539,954 in federal funding and $2,131,454 in non-federal funding.

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