Coordinating unit for the innovative science accelerator program - the goal of the niddk innovative science accelerator (ISAC) program is to not only provide funding for highly innovative hypothesis…

Active Cooperative Agreement Awarded Last action

Award ID
U24DK128851
Recipient
Awarding agency
Obligated
$20,574,986

Award facts

Completion date 93% complete
Originally
Funding
  • $17,574,988.00 Federal
  • $2,999,998.00 Non-federal
Place of performance
Augusta, GA 30912, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Coordinating unit for the innovative science accelerator program - the goal of the niddk innovative science accelerator (ISAC) program is to not only provide funding for highly innovative hypothesis driven research but to deliver a platform for the KUH research community to collaborate, exchange ideas and find resources that will accelerate innovation in areas of interest to that community. Our laboratory has extensive experience in developing these types of resources and managing the activities of national consortia. We are currently the coordinating units (CU) for two niddk consortia, the mouse metabolic phenotyping centers (MMPC) and the diabetic complications consortium (DIACOMP). Both consortia are niddk funded initiatives that provide an environment to foster communication and collaboration between investigator communities involved in metabolic and diabetic complications research. Each sponsors annual meetings in relevant scientific areas, solicits and funds pilot projects in high impact areas of niddk research, and supports websites to serve their respective scientific communities. Over the last 14 years, our group has developed an extensive infrastructure to successfully managed the coordinating units (CU) for these niddk funded consortia (MMPC, 2006-present, DIACOMP, 2011-present). The ISAC-CU will be responsible for supporting ISAC investigators through the use of opportunity pools (funding programs), manage/maintain the website/resources and administratively organize the meetings and workshops sponsored by ISAC to engage the greater KUH scientific community. The ISAC-CU is responsible for creating and maintaining the administrative, scientific and informatics infrastructure necessary to organize and facilitate ISAC's operations. The goal of this proposal is to provide that infrastructure. We will build upon the success of the current CU infrastructure to provide ISAC with a robust and comprehensive service oriented solution that supports the unique aspects of this consortium.

Transactions

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Amendment $1,249,999 $0
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Amendment $74,999 $0
Amendment $1,125,000 $0
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Amendment $1,249,999 $0
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Amendment $500,000 $0
Amendment $500,000 $500,000
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Amendment $1,249,999 $0
Amendment $1,249,999 $1,249,999
Amendment $1,249,999 $0
Amendment $1,249,999 $0
Original award $1,249,999 $1,249,999
Show all 21

Subawards

Subrecipient Amount Awarded
Beth Israel Deaconess Medical Center, Inc. Unraveling the complex behavior of healthy and diseased podocytes by analyzing the changes in their unique arrangement of foot processes, slit diaphragm, and… $0
Northwestern University We aim to uncover a novel transcriptional regulatory mechanism in kidney development mediated by adipocytes located between the kidney and its capsule. This… $100,000
Vanderbilt University Medical Center Obesity and related co-morbidities are a health emergency. Our current understanding of the mechanisms behind obesity and lipotoxicity is based on the "Energy… $0
Beth Israel Deaconess Medical Center, Inc. Unraveling the complex behavior of healthy and diseased podocytes by analyzing the changes in their unique arrangement of foot processes, slit diaphragm, and… $0
Dartmouth-Hitchcock Clinic This project aims to revolutionize the study of urinary incontinence by introducing zebrafish as a novel genetic model for urinary sphincteric dysfunction.… $0
University Of Florida Down syndrome (DS) presents a striking, clinically important pattern of erythroid abnormalities—neonatal polycythemia and persistent macrocytosis—that current… $0
The Children's Hospital Corporation The concept we propose here -increasing human iPSC-derived hematopoietic stem cell (iHSC) yield by mimicking natural inflammatory signaling dynamics (Fig.1)- is… $0
University Of Mississippi Medical Center How metabolic dysregulation promotes polycystic kidney diseases (PKD) remains largely unknown highlighting a critical gap in our understanding of disease… $0
The Ohio State University Acute kidney injury (AKI) is a significant public health problem leading to 1.7 million deaths per year globally. Therapeutic interventions for AKI are… $0
Iowa State University Of Science And Technology The concept we propose here -increasing human iPSC-derived hematopoietic stem cell (iHSC) yield by mimicking natural inflammatory signaling dynamics (Fig.1)- is… $0
Mayo Clinic Acute kidney injury (AKI) is a significant public health problem leading to 1.7 million deaths per year globally. Therapeutic interventions for AKI are… $0
Vanderbilt University Medical Center Although the gonads have long been assumed to be the primary source of bioactive sex hormones, evidence suggests that sex hormones can be produced… $0
Case Western Reserve University This proposal aims to reshape surgical approaches to urinary diversion (UD) following radical cystectomy for bladder cancer patients. For over 70 years,… $0
Trustees Of Indiana University We will deliver the first organ-scale, subcellular-resolution 3D kidney atlases of 10 different disease models, comprising complete 3D reconstructions of… $0
The Children's Hospital Corporation Hematopoietic stem/progenitor cell (HSPC) transplantation (HSCT) remains the only curative option for many hematologic and immunologic disorders, but its… $100,000
University Of Florida Down syndrome (DS) presents a striking, clinically important pattern of erythroid abnormalities—neonatal polycythemia and persistent macrocytosis—that current… $100,000
Case Western Reserve University This proposal aims to reshape surgical approaches to urinary diversion (UD) following radical cystectomy for bladder cancer patients. For over 70 years,… $100,000
Beth Israel Deaconess Medical Center, Inc. Unraveling the complex behavior of healthy and diseased podocytes by analyzing the changes in their unique arrangement of foot processes, slit diaphragm, and… $100,000
Vanderbilt University Medical Center Although the gonads have long been assumed to be the primary source of bioactive sex hormones, evidence suggests that sex hormones can be produced… $100,000
The Ohio State University Acute kidney injury (AKI) is a significant public health problem leading to 1.7 million deaths per year globally. Therapeutic interventions for AKI are… $75,000
Mayo Clinic $75,000
Trustees Of Indiana University We will deliver the first organ-scale, subcellular-resolution 3D kidney atlases of 10 different disease models, comprising complete 3D reconstructions of… $75,000
President And Fellows Of Harvard College Secreted circulating protein factors mediate key aspects of inter-organ communication in the kidney, urological, and hematological systems; however, our ability… $0
Dartmouth-Hitchcock Clinic This project aims to revolutionize the study of urinary incontinence by introducing zebrafish as a novel genetic model for urinary sphincteric dysfunction.… $100,000
Vanderbilt University Medical Center Obesity and related co-morbidities are a health emergency. Our current understanding of the mechanisms behind obesity and lipotoxicity is based on the "Energy… $100,000
Iowa State University Of Science And Technology The concept we propose here -increasing human iPSC-derived hematopoietic stem cell (iHSC) yield by mimicking natural inflammatory signaling dynamics (Fig.1)- is… $100,000
University Of Mississippi Medical Center How metabolic dysregulation promotes polycystic kidney diseases (PKD) remains largely unknown highlighting a critical gap in our understanding of disease… $100,000
Lankenau Institute For Medical Research “Inflammatory Diseases� (IDs) refers to an array of conditions of distinct etiologies that trigger the systemic increase of pro-inflammatory… $0
The Washington University A low nephron number is considered a significant risk factor for susceptibility to chronic kidney disease (CKD). Total nephron number is stablished by birth and… $0
Temple University-Of The Commonwealth System Of Higher Education Acute kidney injury (AKI) is a critical health condition characterized by a sudden decline in kidney function. It occurs in approximately 20%-30% of… $0
Lankenau Institute For Medical Research “Inflammatory Diseases� (IDs) refers to an array of conditions of distinct etiologies that trigger the systemic increase of pro-inflammatory… $0
University Of California, LOS Angeles The past decade has provided ample evidence that humans host an enormous web of interacting microbial communities of great diversity and complexity. Sensitive… $0
President And Fellows Of Harvard College Secreted circulating protein factors mediate key aspects of inter-organ communication in the kidney, urological, and hematological systems; however, our ability… $100,000
President And Fellows Of Harvard College We propose to prevent and treat hyperphosphatemia associated with chronic kidney disease (CKD) by harnessing the power of hydrogel encapsulated… $100,000
University Of Southern California Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease worldwide, characterized by fluid-filled cyst growth and… $100,000
The Washington University A low nephron number is considered a significant risk factor for susceptibility to chronic kidney disease (CKD). Total nephron number is stablished by birth and… $100,000
University Of Massachusetts Medical School The proposed research will test an innovative strategy to make kidney tissue resistant to oxygen deprivation (hypoxia), a phenomenon that occurs during… $100,000
Temple University-Of The Commonwealth System Of Higher Education Acute kidney injury (AKI) is a critical health condition characterized by a sudden decline in kidney function. It occurs in approximately 20%-30% of… $0
Oregon Health & Science University Over the last decade, it has become clear that the bladder and lower urinary tract are not sterile environments, but host a community of microbes like many… $0
Vanderbilt University Medical Center In chronic kidney disease (CKD), excess extracellular matrix (ECM) production, termed fibrosis, is a source of continuous injury. Fibrosis expansion leads to… $0
Board Of Regents Of Nevada System Of Higher Education Penile erection is a highly regulated physiological event that comprises of increased arterial inflow and restricted venous outflow, coordinated with smooth… $0
The General Hospital Corporation Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a significant complication of CKD associated with mortality, for which no curative treatment is… $100,000
Temple University-Of The Commonwealth System Of Higher Education Acute kidney injury (AKI) is a critical health condition characterized by a sudden decline in kidney function. It occurs in approximately 20%-30% of… $68,688
Regents Of The University Of Minnesota Page 2 Form Page 2 What is the expected breakthrough discovery or innovation and how will it change the field? (maximum 360 words) $100,000
Lankenau Institute For Medical Research “Inflammatory Diseases� (IDs) refers to an array of conditions of distinct etiologies that trigger the systemic increase of pro-inflammatory… $100,000
Cleveland Clinic Lerner College Of Medicine Of Case Western Reserve University Our findings support the hypothesis of a common pathway for the development of atherosclerosis and CaOx stones. In this proposal, we will pursue proof of… $0
University Of Florida Our overall paradigm-shifting hypothesis is that the circadian clock functions differently in the kidneys of females compared to males. Our recent, unexpected… $0
Icahn School Of Medicine At Mount Sinai Acute kidney injury (AKI) is a critical health condition characterized by a sudden decline in kidney function. It occurs in approximately 20%-30% of… -$68,688
Show 38 more

Latest 48 listed here. See the rest on GovTribe.

Quick answers

Who received award U24DK128851?

U24DK128851 was awarded to Augusta University Research Institute, Inc. by National Institute of Diabetes and Digestive and Kidney Diseases (National Institutes of Health) on April 15, 2021.

How much is award U24DK128851 worth?

$20,574,986 has been obligated on U24DK128851: $17,574,988 in federal funding and $2,999,998 in non-federal funding.

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