Across the globe, there has been a considerable growth in the number of people diagnosed with parkinsonism. Estimates indicate that from 1990 to 2015 the number of parkinsonism diagnoses doubled, with more than 6 million people currently carrying the diagnosis, and by year 2040, 12 and 14.2 million people will be diagnosed with parkinsonism. Parkinson's disease (PD), multiple system atrophy parkinsonian variant (msap), and progressive supranuclear palsy (PSP) are neurodegenerative forms of parkinsonism, which can be difficult to diagnose as they share similar motor and non-motor features, and they each have an increased chance of developing dementia. In the first five years of a PD diagnosis, about 58% of PD are misdiagnosed, and of these misdiagnoses about half have either MSA or PSP. Since PD, msap, and PSP require unique treatment plans and different medications, and clinical trials testing new medications require the correct diagnosis, there is an urgent need for both clinic ready and clinical-trial ready markers for differential diagnosis of PD, msap, and PSP. Over the past decade, we have developed diffusion imaging as an innovative biomarker for differentiating PD, msap, and PSP. In this proposal, we will leverage our extensive experience to create a web-based software tool that can process diffusion imaging data from anywhere in the world. We will disseminate and test the tool in the largest prospective cohort of participants with parkinsonism (PD, msap, PSP), working closely with the parkinson study group. The reason to test this in the parkinson study group network, is because they are the community that evaluates phase II and phase III clinical trials in parkinsonism. This web-based software tool will be capable of reading raw diffusion imaging data, performing quality assurance procedures, analyzing the data using a validated pipeline, and providing imaging metrics and diagnostic probability. We will test the performance of the waid-p by enrolling 315 total subjects (105 PD, 105 msap, 105 PSP) across 21 sites in the parkinson study group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis. We will also enroll a portion of the cohort into a brain bank to ascertain pathological confirmation and to test the algorithm against cases with post-mortem diagnoses. The final outcome will be to disseminate a validated diagnostic algorithm to the parkinson neurological and radiological community and to make IT available to all on a website.
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Show all 24
Subawards
Subrecipient
Amount
Awarded
Banner HealthUniversity of Florida will receive MRI images from participants enrolled in BBDP to include in their study in order to ascertain pathological confirmation and…
$100,000
University Of South FloridaFor the project titled “Web-based Automated Imaging Differentiation of Parkinsonism” (NIH Award # U01NS119562), Dr. Wu and his team will be responsible for…
University Of California, San DiegoFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
$400
Wake Forest UniversityDouble reported. Amount should only be $38,285.For this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple…
-$38,285
The University Of Kentucky Research FoundationDouble Reported. Correcting to only amount of $30,600. For this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5…
-$30,600
The Pennsylvania State UniversityDouble Reported. Correcting for the only amount of $39,264. For this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease,…
-$39,264
Beth Israel Deaconess Medical Center, Inc.Double reported in FFATA - correcting to the original amount of $31325 and not $62650. For this 3 year study, you are asked to enroll a goal of 15 people (5…
-$31,325
Albany Medical CollegeFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
-$5,053
The General Hospital CorporationDouble reported. Correcting to only $31,080 for this subaward. For this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease,…
-$31,080
Wake Forest UniversityUnder reported. For this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5…
$27,900
University Of California, San DiegoFor this study in Year 4, you are asked to perform Visit 2 on the individuals ready for the Visit 2 testing. The Schedule of events for Visit 2 are below.…
$7,950
University Of South FloridaFor the project titled “Web-based Automated Imaging Differentiation of Parkinsonism” (NIH Award # U01NS119562), Dr. Wu and his team will be responsible for…
$9,138
Beth Israel Deaconess Medical Center, Inc.For this study in Year 4, you are asked to perform Visit 2 on the individuals ready for the Visit 2 testing. The Schedule of events for Visit 2 are below.…
Beth Israel Deaconess Medical Center, Inc.For this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
$31,325
The General Hospital CorporationFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
$31,080
The Johns Hopkins UniversityFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
University Of Alabama At BirminghamFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson's disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
$32,819
Northwestern UniversityFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
$33,970
Pennsylvania State UniversityFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
$39,264
University Of California, San DiegoFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
$27,176
Centre For Addiction And Mental HealthFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
$23,112
University Of Alabama At BirminghamFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson's disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
$32,819
The Johns Hopkins UniversityDouble reported. For this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson…
-$44,213
The Johns Hopkins UniversityFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
Duke UniversityFor this 3 year study, you are asked to enroll a goal of 15 people (5 Parkinson’s disease, 5 multiple system atrophy Parkinson variant, 5 progressive…
U01NS119562 was awarded to University Of Florida by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on April 1, 2021.
How much is award U01NS119562 worth?
$14,333,999 has been obligated on U01NS119562: $11,491,487 in federal funding and $2,842,512 in non-federal funding.
University Of Florida UEI NNFQH1JAPEP3
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services