Collaborative to understand impacts of early preventive interventions on suicide and overdose mortality using data harmonization methodology

Active Cooperative Agreement Awarded Last action

Award ID
U01MH137067
Recipient
Awarding agency
Obligated
$10,746,318

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date 58% complete
Place of performance
Baltimore, MD 21205, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The goal of this application, submitted in response to RFA-MH-23-275, "using secondary data analysis to determine whether preventive interventions implemented earlier in life reduce suicide risk," is to conduct research that will integrate and harmonize existing large prevention trial datasets. The included randomized clinical trials (RCT) were delivered before adulthood (prior to age 18) and did not explicitly target suicidal thoughts and behaviors (STB). Each RCT consists of well-characterized participant-level prospective data with consent that allows for the harmonized data to be submitted to the nimh data archive and allows for national death index searches. This study will examine 'cross-over effects' (e.g., unanticipated beneficial effects) of the rcts in reducing risk for later fatal and nonfatal STB, and related outcomes such as overdose, substance use disorders (SUD), opioid use disorders (OUD), accidents, and all-cause mortality. This U01 proposal has obtained 29 existing prevention trial data sets with collaboration of the principal investigators and data custodians who have rights to the original data. We will DE-identify, aggregate, and harmonize the prevention trial datasets and utilize advanced computational/analytic strategies to examine whether intervening early reduces the risk for STB and related outcomes. We will identify the most potent aspects by examining the various components of each intervention as well as the proximal and distal targets, format, setting, dose/duration, developmental timing, and quality of implementation. Potential mediators and mechanisms of action (e.g., aspects of parenting, social factors, emotional and behavioral regulation) will also be studied and identified. This effort will examine moderators of the effects of preventive interventions, including specific subpopulations (e.g., individuals from historically minoritized and socioeconomically disadvantaged backgrounds), and those individuals experiencing initial elevated levels of risk (e.g., systems-involved youth, youth who had experienced early trauma/adverse childhood events). Data will be utilized from 29 trials involving 14 programs and 42,509 individuals. With over 40,000 participants across all studies, harmonizing data will allow for more complex, multifactorial, multi-level analyses to explore intervention impacts on fatal and nonfatal STB and related outcomes as well as potential mediators, mechanisms, and moderators of impact. The U01 team will oversee the preparation of a final harmonized prevention trial dataset to be deposited to the nimh data archive (NDA) with data dictionaries and associated documentation from the original studies. This project has the potential to inform the refinement and development of future preventive intervention strategies delivered early and scaled to address suicide and overdose in the US.

Transactions

Action Obligated Date
Amendment $2,758,020
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $2,320,210
Amendment $2,834,044
Original award $2,834,044

Subawards

Subrecipient Amount Awarded
Iowa State University Of Science And Technology Iowa State University will provide the Social Development Research Group (SDRG) at the University of Washington with requested data and accompanying… $276,202
University Of Oregon For this study, this site will work closely with JHU and Case Western University (MPI Connell) and Oregon Social Learning Center (Contact PI Tiberio) to provide… $605,016
Oregon Social Learning Center, Inc. The Oregon Social Learning Center (OSLC) will collaborate as a participating site. Dr. Tiberio will serve as the site Principal Investigator and Drs. Patricia… $281,859
University Of Alabama The subaward to The University of Alabama will support the team, led by Co-PI John Lochman, which has been conducting research on the Coping Power program for… $166,492
American Institutes For Research In The Behavioral Sciences AIR will collaborate with Johns Hopkins University (JHU) as a participating site. Dr. Katie Ports will serve as the site Principal Investigator (PI). For this… $101,193
Board Of Regents Of The University Of Nebraska Of particular relevance to the current proposal, UN has contributed to and led several family- and school-focused prevention trials, including those in… $224,460
Research Triangle Institute RTI, lead by Dr. Antonio A. Morgan-López, Principal Investigator (non-contact MPI), will serve as the Coping Power Integrative Data Analysis (CP-IDA) lead… $1,172,387
Case Western Reserve University Case Western Reserve University will collaborate as a participating site. Dr. Connell will serve as the site Principal Investigator. Dr. Connell has expertise… $280,175
University Of Washington The University of Washington Social Development Group will collaborate as a participating site led by Dr. Marina Epstein. She will work with the other MPIs… $1,586,003
University Of Miami For this study, this site will provide JHU with requested data and accompanying codebooks. Additionally, this site will perform a National Death Index search on… $128,802
Oregon Research Institute For this study, this site will provide JHU with requested data and accompanying codebooks. Additionally, this site will perform a National Death Index search on… $181,689
The Pennsylvania State University Penn State will work with its Institutional Review Board (IRB) to establish itself as a site for the SHIELD study. This will include: 1) coordinate with the JHU… $36,873
Rector & Visitors Of The University Of Virginia The University of will be supporting this team by providing access to data from two randomized controlled trials led by Dr. Bradshaw. Specifically, Dr. Wilcox… $179,535
The Regents Of The University Of Colorado For this study, the UCD team will provide JHU with requested data and accompanying codebooks. Additionally, the PRC team will perform a National Death Index… $137,286
University Of Texas Health Science Center At Houston UTH will collaborate with JHU to support and contribute to data harmonization. Dr. Temple will lend his substantive expertise in the dating violence… $288,795
Show all 15

Quick answers

Who received award U01MH137067?

U01MH137067 was awarded to The Johns Hopkins University by National Institute of Mental Health (National Institutes of Health) on August 9, 2024.

How much is award U01MH137067 worth?

$10,746,318 has been obligated on U01MH137067.

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