Coda:?covid and?diabetes?assessment

Active Cooperative Agreement Awarded Last action

Award ID
U01DK137533
Recipient
Awarding agency
Obligated
$44,884,388

Award facts

Completion date 66% complete
Originally
Place of performance
Nashville, TN 37203, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Several studies have found that infection with sars-COV-2 and covid-19 diagnosis are associated with the development and progression of both type 1 (T1D) and type 2 diabetes (T2D), possibly through infection of beta cells, increased insulin resistance, increased inflammation and fibrosis, and other biological processes. The proposed study will take advantage of robust existing infrastructure to rapidly identify, recruit, and retain diverse cohorts of english and spanish speaking pediatric and adult patients with recently diagnosed T1D or T2D. The study will include 1600 study participants diagnosed with diabetes in the last 3 months, who have had a known covid-19 infection in the past 90 days and those with recent diagnosis of diabetes and no known covid-19 infection in the past year. The study will leverage pcornet, a unique national network of over 60 health systems with electronic health record (EHR) data on over 80 million patients and a track record for successful study recruitment. We will query EHR records to swiftly identify potential study subjects with recent diagnosis of diabetes and contact them via patient portals, telephone, face-to-face encounters, and other approaches. We will also leverage the T1D exchange (T1DX), a national network of 54 diabetes centers and an online patient registry of 17,000 individuals with T1D. Consented participants will partake in regular web/mobile or telephone surveys leveraging a previously developed redcap/twilio platform. Participants will also come to sites for regular serological testing, and a subsample will participate in more robust testing of glucose tolerance, biomarkers, and vascular function. This data will be supplemented by longitudinal EHR data from participating sites and across pcornet. Participants will be followed for 2 years. Aim 1 will examine if patients with recent T2D who have recent covid-19 are more likely to have worse glycemic control, increased inflammation and increased insulin resistance than patients without recent covid-19. Aim 2 will examine if patients with recent T1D who have recent covid-19 are more likely to have worse glycemic control, increased inflammation and more rapid reduction in beta cell function than patients without recent covid-19. Aim 3 will evaluate a subset of patients with diabetes to examine if covid-19 is associated with worse vascular function, increased inflammation and hypercoagulability. Aim 4 will explore the role of genomic/social/environmental factors on inflammation and metabolic function. Aim 5 will leverage EHR data to explore the role of covid-19 and covid-19 treatments on diabetes development and diabetes-related outcomes across the pandemic. The study will be led by a team with significant experience related to covid-19, post-acute sequelae of covid-19 (pasc), obesity and diabetes in children and adults, epidemiological research, informatics, health services research, genomics, metabolomics, physiology, patient and family engagement and other areas. The proposed work will provide a deeper understanding of the relationship between covid-19 and diabetes, that can support future interventions and public health approaches to improve health.

Transactions

Action Obligated Date
Amendment Coda: covid and diabetes assessment - several studies have found that infection with sars-COV-2 is associated with the development and progression of both… $8,528,886
Amendment $0
Amendment $319,107
Amendment $289,235
Amendment $289,235
Amendment $241,579
Amendment $241,579
Amendment $7,658,555
Amendment $7,658,555
Amendment $7,658,555
Amendment $5,999,551
Original award $5,999,551
Show all 12

Subawards

Subrecipient Amount Awarded
Regents Of The University Of Minnesota CODA: COvid and Diabetes Assessment $72,384
Emory University $914,017
The Regents Of The University Of Colorado $283,170
Childrens Hospital Medical Center $74,584
University Of Alabama At Birmingham $71,009
University Of Miami $72,246
The University Of Texas Southwestern Medical Center $76,684
Duke University $198,157
Harvard Pilgrim Health Care, Inc. $511,587
Mayo Clinic $104,453
The Johns Hopkins University $75,065
Weill Medical College Of Cornell University $83,742
T1D Exchange, Inc. $31,161
The Medical University Of South Carolina $71,559
Emory University $331,879
University Of Alabama At Birmingham $100,000
University Of Pittsburgh - Of The Commonwealth System Of Higher Education $340,498
T1D Exchange, Inc. $31,161
University Of Miami $42,213
Childrens Hospital Medical Center $99,999
Duke University $153,225
Regents Of The University Of Minnesota $100,000
The University Of Iowa $127,238
The Johns Hopkins University $120,000
The University Of Texas Southwestern Medical Center $100,000
Weill Medical College Of Cornell University $83,743
University Of Pittsburgh - Of The Commonwealth System Of Higher Education $35,430
Research Institute At Nationwide Children's Hospital $76,550
The Children's Hospital Of Philadelphia $120,000
Emory University $214,103
The Medical University Of South Carolina $78,475
Ochsner Clinic Foundation $90,814
Mayo Clinic $84,088
The Regents Of The University Of Colorado $146,599
The Leland Stanford Junior University $140,660
Baylor College Of Medicine $120,000
Harvard Pilgrim Health Care, Inc. $511,587
Research Institute At Nationwide Children's Hospital $194,810
The Leland Stanford Junior University $256,786
The Medical University Of South Carolina $191,242
University Of Pittsburgh - Of The Commonwealth System Of Higher Education $35,429
Ochsner Clinic Foundation $248,140
Baylor College Of Medicine $203,273
The Children's Hospital Of Philadelphia $225,437
The University Of Iowa $190,218
The Johns Hopkins University $206,808
The Children's Hospital Of Philadelphia $80,534
The Regents Of The University Of Colorado $177,255
University Of Pittsburgh - Of The Commonwealth System Of Higher Education $347,811
Harvard Pilgrim Health Care, Inc. $556,040
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Quick answers

Who received award U01DK137533?

U01DK137533 was awarded to Vanderbilt University Medical Center by National Institute of Diabetes and Digestive and Kidney Diseases (National Institutes of Health) on July 21, 2023.

How much is award U01DK137533 worth?

$44,884,388 has been obligated on U01DK137533.

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