The objective of this study is to determine the effects of spaceflight on cell and tissue dysfunction along the brain-liver-GUT axis and to determine the role of these perturbations in accelerating…
Active Definitive Contract Awarded Last action
- Contract number
- 80ARC023CA007
- Awardee
-
Rensselaer Polytechnic Institute UEI U5WBFKEBLMX3
- Awarding agency
-
Ames Research Center
National Aeronautics and Space Administration
- Obligated
- $1,105,098
Award facts
- Opportunity
-
- NASA Research Announcement (NRA): Extended Longevity of 3D Tissues and Microphysiological Systems for Modeling of Acute and Chronic Exposures to Stressors Solicitation · NNH21ZDA015N · Posted May 27, 2021
- Contract value 100% obligated
- $1,105,098.00 Current and potential, with all options
- Completion date 94% complete
- Current and potential, with all options
- Contracting staff
- NAICS code
- 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Set-aside
- No set-aside
- Competition
- Full and Open Competition · 9 offers Basic Research
- Pricing
- Firm Fixed Price
- Place of performance
- Troy, NY, USA
Award details come from SAM.gov/FPDS.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Funding Only Action | $285,947 | |
| Funding Only Action | $278,792 | |
| Funding Only Action | $250,000 | |
| Original award | $290,359 |
About this award
NASA's Ames Research Center awarded a $1.105 million firm fixed-price definitive contract to Rensselaer Polytechnic Institute on February 2, 2023, to determine the effects of spaceflight on cell and tissue dysfunction along the brain-liver-gut axis and to characterize the role of these perturbations in accelerating tissue degeneration associated with aging.
Performance is located in Troy, NY. The award derives from a multi-agency Research Announcement issued May 27, 2021, by NASA, NIH, HHS BARDA, and FDA soliciting proposals to develop 3D tissues and microphysiological systems with extended longevity of at least six months to model acute and chronic exposures to stressors. The ultimate completion date is January 31, 2027.
The Johns Hopkins University serves as a major subcontractor. The Johns Hopkins effort focuses on developing human gut and microbiome microphysiological systems derived from induced pluripotent stem cells, vascularizing those systems with blood vessels formed from iPSC-derived endothelial cells and pericytes, and establishing culture longevity using novel stable-release growth factor technology. Johns Hopkins will also assist in planning, performance, and analysis of perturbation studies examining the role of chronic inflammation, spaceflight, and aging on the brain-liver-gut axis with focus on cellular senescence and mitochondrial dysfunction.
Description
The objective of this study is to determine the effects of spaceflight on cell and tissue dysfunction along the brain-liver-GUT axis and to determine the role of these perturbations in accelerating tissue degeneration associated with aging.
Subawards
| Subcontractor | Amount | Awarded |
|---|---|---|
| The Johns Hopkins University | $489,712 |
Quick answers
Who was awarded contract 80ARC023CA007?
80ARC023CA007 was awarded to Rensselaer Polytechnic Institute by Ames Research Center (National Aeronautics and Space Administration) on February 2, 2023.
How much is contract 80ARC023CA007 worth?
The government has obligated $1,105,098 on 80ARC023CA007.
Was contract 80ARC023CA007 competed?
The extent of competition for 80ARC023CA007 was full and open competition. The government received 9 offers.
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