Immune mechanisms of protection against mycobacterium tuberculosis center (impac-TB)
Active Definitive Contract Awarded Last action
- Contract number
- 75N93019C00071
- Awardee
-
President And Fellows Of Harvard College UEI UNVDZNFA8R29 Part of Harvard College President & Fellows Of
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $59,907,089
Award facts
- Opportunity
-
- BAANIAIDNIHAI201700104 Solicitation number
- Immune Mechanisms of Protection Against Mycobacterium tuberculosis Center (IMPAc-TB) Award Notice · Posted Jan 25, 2018
- Contract value 96% obligated
-
- $59,907,088.77 Current, with exercised options
- $62,413,507.77 Potential, with all options
- Completion date 88% complete
- Current and potential, with all options
- NAICS code
- 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Set-aside
- No set-aside
- Competition
- Full and Open Competition · 12 offers Negotiated Proposal / Quote
- Pricing
- Cost No Fee
- Place of performance
- Boston, MA 02115, USA
- Legislative mandates
-
- Employment Eligibility Verification (E-Verify) FAR subpart 22.18
- Service Contract Inventory FAR subpart 4.17
Award details come from SAM.gov/FPDS.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Funding Only Action | $2,633,311 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Exercise an Option | $3,702,854 | |
| Funding Only Action | -$1 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Exercise an Option | $7,988,857 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Exercise an Option | $8,742,782 | |
| Vendor DUNS or Name Change - Non-Novation | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Change Order | $9,252,840 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Exercise an Option | $8,747,706 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Exercise an Option | $8,191,193 | |
| Modification | $10,647,547 | |
| Other Administrative Action | $0 |
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About this award
The National Institute of Allergy and Infectious Diseases awarded a $62.413 million definitive contract to President And Fellows Of Harvard College on September 30, 2019, for the Immune Mechanisms of Protection Against Mycobacterium Tuberculosis Center (IMPAC-TB), a cost-no-fee research program with no set-aside, ultimate completion by September 29, 2027.
Place of performance is Boston, MA. The contract funds a multi-institutional research center investigating immune mechanisms underlying protection against tuberculosis infection and disease progression across human clinical cohorts and nonhuman primate models. Research scope encompasses five core projects: protection from infection after IV BCG vaccination; natural control of Mycobacterium tuberculosis infection in nonhuman primates; identification of cross-species translatable determinants of TB phenotypes; resistance to IGRA+/TST+ latent TB infection; and the reverter project examining IGRA reversion. Cross-cutting technology platforms include systems serology, single-cell RNA sequencing, mass cytometry (CyTOF), mechanistic dissection of innate and T cell functions, computational modeling, and data resource management.
The ceiling value is $62.413 million. Place of performance includes clinical and research sites in Boston and subordinate international locations in South Africa (Cape Town and Durban), Uganda (Kampala), and the United Kingdom (London).
Subcontractors and sub-awardees include Massachusetts General Hospital (systems serology and single-cell RNA sequencing), Massachusetts Institute of Technology (computational modeling and mechanistic dissection), University of Pittsburgh (nonhuman primate studies), University of Massachusetts Medical School (small animal mechanistic studies and TCR specificity analysis), University of Washington (mass cytometry harmonization), Case Western Reserve University (clinical studies in Uganda), University of Colorado-Denver (computational analysis of immune signatures), University of Cape Town (reverter immunological characterization), Stellenbosch University (acute Mtb exposure outcomes), and Africa Health Research Institute (cross-species TB phenotype analysis).
Service Contract Inventory data (FY2021–FY2025) shows invoiced labor ranging from $6.2 million (FY2021) to $9.1 million (FY2023–FY2024), declining to $7.4 million in FY2025. Most recent reported footprint (FY2025): 34.9 FTEs delivering 72,554 contractor hours at a derived blended rate of $102.01/hr. Subcontractor engagement in FY2025 accounted for 78% of contractor hours across 13 subcontractors.
Subawards
Show all 25
Quick answers
Who was awarded contract 75N93019C00071?
75N93019C00071 was awarded to President And Fellows Of Harvard College by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on September 30, 2019.
How much is contract 75N93019C00071 worth?
The government has obligated $59,907,089 on 75N93019C00071. Its potential value, with all options, is $62,413,508.
Was contract 75N93019C00071 competed?
The extent of competition for 75N93019C00071 was full and open competition. The government received 12 offers.
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