Seqmatic, LLC

Seqmatic, LLC, a minority-owned, Asian-Pacific American-owned small business based in Fremont, California, provides next-generation DNA and RNA sequencing, whole-genome and whole-exome analysis, and genomic bioinformatics services as a prime contractor (100% of recent awards) to civilian federal research agencies. The company operates across NAICS 541380 (Testing Laboratories and Services) and 541714 (Research and Development in Biotechnology), competing predominantly in full-and-open procurements with occasional Total Small Business set-asides; set-aside posture does not anchor its portfolio.

Seqmatic's customer base concentrates heavily on the National Institutes of Health ecosystem and USDA agricultural research. The National Cancer Institute dominates the potential-value ranking, anchoring the portfolio with a single $149.17 million multiple-award indefinite delivery contract (awarded January 2025, extending through January 2030) for genome characterization center services covering high-throughput DNA and RNA sequencing, whole-exome sequencing, epigenetic characterization, and single-cell/single-nuclei sequencing to support NCI cancer genomics research. The remaining 99 percent of combined potential value fragments across 48 smaller purchase orders. NOAA places seven awards totaling $394 thousand for marine species population genetics sequencing (including a $135 thousand three-year contract awarded July 2024 for next-generation sequencing services extending through June 2027). USDA Agricultural Research Service field units place six orders in the Northeast Area totaling $384 thousand for crop genomics work, including whole-genome sequencing of cotton, lentil, and alfalfa genotypes. The National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Drug Abuse, National Institute on Aging, and National Institute of Allergy and Infectious Diseases collectively account for smaller but recurring single-sample and bulk RNA-sequencing task orders. FDA, CDC, U.S. Army Corps of Engineers, U.S. Geological Survey, and the Department of Veterans Affairs round out the customer roster with specialized sequencing projects. Seven awards (combined potential value $552 thousand) face ultimate completion within the next twenty-four months and therefore carry recompete risk for the vendor.

The award footprint shows modest activity growth from one award in 2022 to twelve in 2023–2024, with activity moderating to ten awards in 2025 and two year-to-date in 2026. Obligated dollars across the portfolio total $2.2 million (1% of combined potential value), reflecting the nascent stage of the large NCI contract and the characteristically small ceiling values of purchase orders for specialized genomics services. Representative named work includes a $129.82 thousand Total Small Business cotton DNA sequencing order (USDA, April 2026) covering 550 cotton leaf samples with quality assessment and Illumina NovaSeq sequencing; a $141.475 thousand small-business set-aside purchase order (National Institute on Drug Abuse, September 2025) for whole-genome sequencing of 325 samples stored ten or more years; an $85.676 thousand Total Small Business NovaSeq DNA sequencing contract (NOAA, September 2022, extended through September 2025) for genetic population structure analysis of commercially managed Alaskan fish species; and a $79.92 thousand USDA contract (September 2023) for DNA extraction, library construction, and sequencing of 672 piglet fecal samples. Seqmatic operates from its Fremont headquarters and maintains performance capacity in St. Paul, Minnesota, Auburn, Alabama, and Silver Spring, Maryland, depending on customer location requirements. The vendor carries no subcontract exposure; all work is performed as prime.

SeqMatic is a San Francisco Bay Area based Illumina, 10X Genomics and Parse Biosciences Certified Service Provider (CSP) of Next Generation Sequencing (NGS) services. We offer comprehensive NGS and other omics services (spatial, histopathology, epigenetics, proteomics) with unparalleled customer service and fast turnaround time. Our scientists specialize in tailoring each project experiments to satisfy specific needs with expert and friendly service.