Prenosis, Inc.
Chicago, IL
Company facts
- FY2025 rankings
- Self-certified in SAM.gov
- Entity structure
- Corporate Entity (Not Tax Exempt)
- Other NAICS codes in SAM.gov
- SAM.gov registration date
- Physical address
- Iitri Center, 3440 S Dearborn St 216 s, Chicago, IL 60616, USA
- Website
- prenosis.com
- Employees
- 11-50
- Estimated annual revenue
- $1M-$10M
- Industry
-
- Health Care
- Pharmaceuticals, Biotechnology & Life Sciences
- Biotechnology
- SIC code
- 87 Engineering & Management Services
Registration and certifications come from SAM.gov and the SBA; company details from public web sources. Updated .
Contract obligations by fiscal year
| Fiscal year | Obligated |
|---|---|
| FY2027 To date | $0 |
| FY2026 | $0 |
| FY2025 | $20,508,783 |
| FY2024 | $999,523 |
| FY2023 | $1,299,000 |
Contract awards
Grant awards
Latest 5 listed here. See the rest on GovTribe.
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About the company
Prenosis, Inc., a self-certified small disadvantaged business based in Chicago, Illinois, develops AI-enabled diagnostic and predictive analytics platforms for infectious diseases and acute respiratory conditions as a prime contractor on federal contracts and grants, with no subcontracting footprint. The company operates exclusively on full-and-open (non-set-aside) awards despite its small disadvantaged business designation, securing work through definitive contracts and Small Business Innovation Research (SBIR) Phase II grants from the Department of Health and Human Services and related federal research agencies.
Prenosis's capability portfolio centers on machine-learning diagnostic tools and precision medicine platforms built on a proprietary biobank. The NOSIS dataset links clinical data to over 91,000 biospecimens from more than 23,000 infection patients at ten U.S. hospital sites, with plasma samples assayed for 43 protein biomarkers and combined with electronic medical record data via AI to construct endotype classifications and host-response maps. The Immunix platform, an FHR/HL7-compatible software system, deploys these diagnostics and clinical decision-support tools at point of care. Prenosis received FDA authorization in April 2024 for the Sepsis Immunoscore, the first AI diagnostic for sepsis. Recent prime awards include a $20 million definitive contract from the Office of the Assistant Secretary for Preparedness and Response (awarded September 30, 2025, running through August 1, 2029) for host-based diagnostics and expansion of the Immunix platform for severe acute respiratory infections and ARDS; a $749,000 contract from ASPR (awarded May 8, 2023) for a three-site clinical study of Sepsis Immunoscore implementation feasibility; and a $1.218 million SBIR Phase II grant from the National Heart, Lung, and Blood Institute (awarded September 1, 2026, through July 31, 2028) for development and validation of the Heart Failure CardioScore, an AI diagnostic for acute heart failure in emergency department patients.
Customer concentration sits heavily with the Department of Health and Human Services Office of the Assistant Secretary for Preparedness and Response, which accounts for 3 awards with $21.5 million in combined potential value and anchors the portfolio. The National Institute of General Medical Sciences (under NIH) holds 4 awards across the recent footprint, with the Defense Threat Reduction Agency representing a single $4.3 million contract award. Seven distinct federal agencies or sub-agencies have placed awards. Prenosis acts as sole prime on all recent work, with no subcontracting relationships in the source data. Recent grant awards span NIGMS research grants focused on heterogeneous treatment effects in sepsis, time-trajectory host-response mapping, and clinical validation of the point-of-care endotyping platform. Two awards face ultimate completion within the next twenty-four months, positioning potential recompete opportunity in FY 2027.
Quick answers
Is Prenosis, Inc. registered in SAM.gov?
Yes. Prenosis, Inc.'s SAM.gov registration is active through February 2, 2027.
What is Prenosis, Inc.'s CAGE code?
Prenosis, Inc.'s CAGE code is 75AY2, and its Unique Entity ID (UEI) is F4S5H4BLMZL5.
How much has Prenosis, Inc. received in federal contracts?
Federal contracts obligated $20,508,783 to Prenosis, Inc. in fiscal year 2025 and $22,807,306 in fiscal years 2023 through 2027.
How does Prenosis, Inc. rank among federal contractors?
Prenosis, Inc. ranked #13 in PSC AN13, #23 in NAICS 541714 and #40 in PSC AN in FY2025.
What is Prenosis, Inc.'s most recent federal award?
Prenosis, Inc.'s most recent federal grant award is Derivation and validation of the heart failure cardioscore: an AI diagnostic for heartfailure using novel biomarkers… (R44HL180159), from National Heart Lung and Blood Institute (NIH), on September 1, 2026.
On GovTribe
See Prenosis, Inc.'s full federal record
- Federal contract awards
- IDV awards
- Federal grant awards
- Funding analysis by agency, NAICS and set-aside
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