Health Research, Inc.

Health Research, Inc.'s Roswell Park Division (doing business as Health Research At Roswell Park) is a tax-exempt, not-for-profit research organization affiliated with Roswell Park Comprehensive Cancer Center in Buffalo, New York, that functions as a prime recipient of federal biomedical research grants—concentrating in cancer biology, immunology, clinical trials, and biostatistics services delivered to the National Institutes of Health, Defense Health Agency, and the Department of Veterans Affairs.

The vendor operates as a prime grant recipient on 514 of 618 recent federal awards (83%), with a subcontractor footprint on 104 awards (17%). Across the grant portfolio, Health Research At Roswell Park conducts hypothesis-driven basic, translational, and clinical cancer research spanning ovarian cancer lineage plasticity and immunosuppression, breast cancer metabolism and metastasis, lung cancer mechanisms and therapeutic resistance, triple-negative breast cancer immunotherapy, bladder cancer biology and chemotherapy resistance, hematologic malignancies including acute myeloid leukemia and multiple myeloma, and tobacco-related disease prevention and regulatory science. The organization also operates shared research infrastructure including biostatistics, bioinformatics, genomics, and biorepository services that support cancer center investigators and multi-institutional consortia. Representative prime grant work includes a $4.2 million Defense Health Agency award for a first-in-human CD83 CAR T-cell therapy trial for relapsed acute myeloid leukemia (July 2026–June 2030), a $2.39 million Defense Health Agency grant on epitranscriptomic pathways in aggressive breast cancer (June 2026–May 2030), a $1.64 million National Institute of General Medical Sciences award developing AKT isoform-selective peptide arrays for kinase activity screening (September 2026–August 2028), and multiple National Cancer Institute grants investigating PI3K signaling in ovarian cancer, neuroendocrine bladder cancer modeling, colorectal cancer targeted therapy combinations, and lung cancer lineage plasticity.

The National Cancer Institute anchors 219 of the vendor's awards (35% of total count) with combined potential value of $1.4 million, followed by the broader National Institutes of Health portfolio (154 awards), the Defense Health Agency (51 awards), and the Department of Defense (39 awards). The top five customer agencies account for 79% of awards by count. Veterans Integrated Service Network 2 represents the second-largest potential-value customer ($131 thousand across 7 awards) through VA contracts for bioinformatics and biostatistical data analysis services, though this is substantially smaller than the NCI concentration. Awards have been awarded consistently across recent years—47 in 2024, 45 in 2025, 32 in 2026, and 1 in 2027—with 59 awards facing completion inside the next twenty-four months and thus subject to recompete risk.

As a child organization of Health Research, Inc., a parent tax-exempt not-for-profit based in Menands, New York, the Roswell Park Division operates integrated research teams delivering work through internal faculty and shared institutional resources rather than relying predominantly on external subcontractors. The vendor's subcontract profile is characterized by collaboration with academic and clinical research institutions—Fred Hutchinson Cancer Center, University of Pennsylvania, Kaiser Foundation Hospitals, Northwestern University, Duke University, Columbia University, and others—as a named sub-recipient supporting data analysis, specimen processing, genomics, and specialized assays on multi-institutional consortium grants and clinical trials. Service Contract Inventory activity is minimal (5 SCI records across FY2022–FY2025, all as subcontractor), indicating that the vendor's federal revenue stream is dominated by grant mechanisms rather than service contracts. The organization does not hold federal contract IDVs or government-wide acquisition vehicles; all transaction activity is grant-based and delivered through prime grant awards and sub-grant collaborations with lead institutions. Health Research At Roswell Park operates without visible SBA set-aside designations and competes for funding under full-and-open processes through peer-reviewed grant mechanisms administered by NIH institutes, agencies, and their subsidiary programs.