Cyion Technologies LLC

Cyion Technologies LLC, a minority-owned, woman-owned small business based in Pleasanton, California, develops biomedical instrumentation and electrophysiology electronics for federal research agencies as a prime grant recipient (50% of recent awards) and as a subcontractor on NIH-funded academic research. The company operates as a limited liability partnership and has received federal grant funding from the National Institutes of Health across cardiac electrophysiology and biomedical imaging research.

Cyion's federal footprint concentrates entirely within the Department of Health and Human Services National Institutes of Health. Four of six awards (100% coverage across the vendor's small portfolio) come from the National Heart Lung and Blood Institute, with one award each from the National Institute of Biomedical Imaging and Bioengineering and the National Institute of Neurological Disorders and Stroke. The company's primary customer relationship is NHLBI, which funded Cyion's Phase I SBIR grant in September 2023 for development of a novel in vitro electrophysiology system to measure cardiomyocyte action potential using a 3D nanoelectrode array developed at Stanford University. That award carries a completion date of August 31, 2026.

As a sub-recipient, Cyion collaborates with The Leland Stanford Junior University on three NIH RO1 proposals dating from December 2023, July 2024, and October 2025. Under these partnerships, Cyion develops 64-channel DC-coupled amplifier electronics, printed circuit boards, control software, and data-analysis tools to support intracellular electrophysiology recordings of stem-cell-derived cardiomyocytes, while the Stanford Cui laboratory focuses on developing the nanoelectrodes and mesh-electrode sensors. The October 2025 sub-award is the company's most recent federal transaction. One award (combined potential value $1.2 million across all six awards) reaches completion within the next twenty-four months, creating limited near-term recompete exposure for the vendor.