Project Grant R41NS102026

Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...

This $1,417,500 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) funds the development of "Electrified Cryo-EM", a novel tool that can kinetically trap biological systems in their metastable, non-equilibrium states. The research aims to unravel the structural changes in neurons during an action potential across multiple length scales, from voltage-gated channel proteins to the synaptic junction. Specifically,...

This NSF Engineering Program award of $605,320 to North Carolina State University (NC State) supports the development of a flexible, FMRI-compatible neural probe with multi-modal sensing and modulation capabilities. The novel probe is designed to advance understanding of neural circuit dynamics and enable closed-loop neuromodulation for treating neurological disorders. Key product elements include: Flexible, multi-shank neural probe fabricated using polymeric materials to enable deep brain...

This $275,000 project grant from the National Science Foundation's Engineering Directorate (CFDA 47.041) will fund the development of novel electronic-photonic silicon carbide neural probes for recording and stimulating neural activity. The Georgia Tech Research Corporation will receive funding on behalf of collaborating researchers to design penetrating neural probes made entirely of silicon carbide, a robust material proven to withstand the corrosive brain environment long-term. The probes...

FAST-ET Cooperative Agreement Summary Boston Children's Hospital received a $5.2M Cooperative Agreement from the National Institute of Neurological Disorders and Stroke (NINDS) under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) for the FAST-ET project, awarded August 1, 2025, with completion targeted for July 31, 2028. The award funds development of an integrated imaging solution combining gridtape-based automated section collection with...

The National Science Foundation awarded Cardiophi LLC $532,000 under the Technology, Innovation, and Partnerships program to develop an artificial intelligence solution for the automated interpretation of electrocardiograms. The project aims to refine existing deep learning-based algorithms for detecting irregular heartbeats, develop methods for predicting the onset of cardiac arrhythmias, and create interpretable and explainable tools to provide insights from ECG signals to clinicians....

Grant Award Summary Neurolux Inc. received a $525,824 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 1, 2025, with completion scheduled for August 31, 2027. The company is commercializing an Electromechanically Monitored Engineered Heart Tissue (EMEHT) platform, a non-animal testing system developed at Northwestern University that enables assessment of cardiac disease and therapeutic...

This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $434,716 to the University of Oklahoma Health Sciences Center to develop a set of optical tools for capturing and interpreting high-speed recordings of neural activity across the entire zebrafish brain. The key objectives are to create fluorescent voltage sensors, optical microscopes, and signal processing algorithms that can simultaneously monitor millisecond-scale bursts of neural...

The Johns Hopkins University was awarded a $2,008,605 Project Grant under the National Institute of Neurological Disorders and Stroke's 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant funding will support the development of an "Autonomous Rapidly Adaptive Multiphoton Microscope for Neural Recording and Stimulation." This adaptive multiphoton microscope system will leverage hybrid volumetric scanning,...

Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $228,045 to the University of California, Berkeley on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop ultrafast wireless voltage imaging technology using event-based cameras. The project, which runs through January 31, 2028, aims to advance neuroscience research by enabling high-speed capture of...