Base Pair Biotechnologies Inc.

Base Pair Biotechnologies Inc. is a for-profit corporate entity based in Pearland, Texas, specializing in advanced biotechnology research and development, with a primary focus on aptamer-based technologies and diagnostic solutions. The company is registered in SAM.gov and provides innovative scientific services to various federal agencies, particularly in the fields of drug detection, medical diagnostics, and targeted therapeutic technologies. Base Pair Biotechnologies leverages its expertise in aptamer engineering and molecular biology to develop cutting-edge detection and measurement technologies for complex scientific challenges.

In terms of federal contract awards, Base Pair Biotechnologies has received contracts from agencies like the National Institute on Drug Abuse (NIDA) and the CDC Pittsburgh. Their contract work includes developing aptasensors for measuring long-term adherence to HIV treatment regimens, with a $300,000 firm fixed price contract under the Small Business Innovation Research (SBIR) program. The company has been awarded contracts set aside for small businesses, focusing on specialized research and development services that address critical healthcare and scientific challenges. Their contract work demonstrates a capability to produce custom research solutions and develop innovative technological approaches for federal agencies.

Through federal grant awards, Base Pair Biotechnologies has secured significant funding from multiple prestigious institutions, including the National Institute of Biomedical Imaging and Bioenginering, National Heart Lung and Blood Institute, National Institute of Allergy and Infectious Diseases, and the Institute of Food Production and Sustainability. Their grant-funded projects encompass a wide range of innovative research initiatives, such as developing bench-top readers for rapid drug/opiate detection, engineering lentiviral vectors for cardiac gene therapies, creating aptamer-based sensors for herbicide detection, and designing quantitative point-of-care measurements for tuberculosis treatment adherence. These grants demonstrate the company's versatility in addressing complex scientific challenges across multiple domains, including healthcare, agriculture, and diagnostic technologies.

Base Pair Biotechnologies, Inc. is a world-leading provider of highly customized aptamer discovery and development services. The company is five years old, privately held, and located in the Houston, Texas metropolitan area, close to major medical centers and universities.

Technology

Base Pair's intellectual property portfolio includes more than two dozen issued and pending patents as well as trade secrets related to aptamer selection, aptamer screening, and aptamer sequences. Base Pair's patented multiplex selection process reduces time and cost for aptamer discovery and facilitates development of specific- and pan-binders to related targets. Base Pair also has proprietary aptamer libraries that contain novel modifications, modulating binding properties and increasing conformational diversity. Base Pair has several proprietary techniques for developing aptamers to small molecules and uses novel methods for determining solution phase affinity.