Complementary and Integrative Health - Research Projects

Active

Assistance listing
93.473
Agency
Grant awards
Not on record

Program facts

Treasury account
  • 75-0896-0-1-552
More information

Program details come from SAM.gov Assistance Listings. Updated .

About this program

The National Institutes of Health (NIH), through the National Center for Complementary and Integrative Health (NCCIH), funds research into complementary and integrative health approaches under CFDA 93.473, with multiple grant opportunities posted in 2025–2026 and a near-term due date of October 30, 2026 for a phased clinical trial on joint pain mechanisms.

NCCIH funds rigorous peer-reviewed research spanning foundational mechanistic studies, clinical trials, and implementation science on complementary and integrative treatments—including botanicals, dietary supplements, mind-body interventions such as meditation and yoga, acupuncture, and whole-person health approaches. Recent solicitations emphasize holistic, multisystem investigation of natural products for chronic pain management, pragmatic trials embedded in routine clinical care, and multi-site feasibility studies of mind and body interventions on whole-person health restoration. The program funds research and academic institutions, private companies, nonprofit organizations, and for-profit entities through a rigorous two-stage peer-review process; applications are submitted via Grants.gov using the SF 424 (Research and Research-Related) and PHS 398 forms.

Research grants dominate the assistance-type mix, with cooperative agreements present in specific solicitations such as pragmatic trials conducted in health care systems. Award mechanisms include single project grants, multi-project grants, and collaborative program grants for interdisciplinary teams of three to six investigators. Peer review evaluates scientific merit, innovation, experimental design, investigator competency, facility adequacy, budget necessity, and relevance to program objectives; applicants may appeal review process flaws, bias, conflict of interest, or factual errors within 30 calendar days of the second peer review level.

Timeline from application submission to award decision ranges from 180 to 300 days; research grants and cooperative agreements require approximately 6–10 months. Grantees must retain financial and programmatic records for 3 years from the date the annual financial status report is submitted.

Five grant opportunities are currently posted or forecasted. The NIH Pragmatic Trials in Health Care Systems (PAR-28-010, Cooperative Agreement, posted April 29, 2026) supports large-scale trials testing intervention effectiveness in routine clinical care and implementation strategies within health systems, with milestone-driven phased awards for planning and full trial execution. A Holistic Approach to Study Non-Addictive Natural Products for Pain Management (PAR-28-009, posted April 22, 2026) solicits collaborative interdisciplinary research on natural products for chronic pain aligned with the NIH HEAL Initiative. The Collaborative Program Grant for Interdisciplinary Teams (PAR-27-003, posted February 19, 2026, due September 26, 2029) supports highly integrated three-to-six-investigator teams on ambitious shared research objectives. HEAL Initiative: Whole Joint Health Program (PAR-27-045, posted February 17, 2026, due October 30, 2026) supports phased mechanistic clinical research identifying multi-tissue mechanisms of joint pain, then testing non-pharmacological or multimodal interventions; total project duration cannot exceed 5 years. Assessing Feasibility of Incorporating Mechanisms in Multi-site Clinical Trials of Mind and Body Interventions (PAR-28-091, posted July 8, 2025, due November 16, 2029) funds multi-site feasibility studies of mind and body interventions on whole-person health restoration using the Whole Person Health Index as the clinical outcome measure.

Objective and description

Objective

NCCIH is the lead Federal agency for scientific research on the fundamental science, usefulness, and safety of complementary and integrative treatments and practices. NCCIH seeks to build knowledge across disciplines, focusing on the whole person, an

Description

The National Center for Complementary and Integrative Health (NCCIH) provides funding for research into complementary and integrative health approaches. Eligible entities (including, but not limited to: research and academic institutions, private companies) may submit research grant applications using the Grants.gov website. All applications undergo a rigorous, 2-stage, peer-review system, and funding decisions are made based on the review of applications that are most meritorious and responsive to the mission of NCCIH.

Eligibility

Applicant eligibility

Universities, colleges, hospitals, laboratories, and other public or private nonprofit domestic institutions, including State and local units of government, and individuals are eligible to make application for grant support of research by a named principal investigator or a research career development candidate. For-profit organizations are also eligible.

Uses of assistance

Any nonprofit or for-profit organization, company, or institution engaged in biomedical research.

Use restrictions

Research Project Grants (including most Cooperative Agreements): Awards are usually made for a 12-month period with recommendation of up to 4 years of additional support. See the following for information on how assistance is awarded/released: The Notice of Award (NoA) is the legal document issued to notify the grantee that an award has been made and that funds may be requested from the designated HHS payment system or office. A NoA is issued for the initial budget period. If subsequent budget periods are also approved, the NoA will include a reference to those budgetary commitments. Funding for subsequent budget periods are generally provided in annual increments following the annual assessment of progress. This funding is also contingent on the availability of funds. The NoA includes all applicable terms of award either by reference or specific statements. It provides contact information for the assigned program officer and grants management specialist. The grantee accepts an NIH award and its associated terms and conditions by drawing or requesting funds from the Payment Management System, or upon the endorsement of a check from the US Treasury for foreign awardees. Method of awarding/releasing assistance: lump sum

How to apply

Criteria for selecting proposals

Research grants: Single project grant applications must be prepared electronically through grants.gov (http://www.grants.gov) using the SF 424 (Research and Research-Related) and PHS 398 instructions.Multi-project grant applications must be submitted through the A.S.S.I.S.T (Application Submission System & Interface for Submission Tracking) system. Individual funding opportunity announcements will indicate the appropriate application format to be used. A listing of NCCIH and other funding opportunities can be found through the NCCIH web site (http://www.nccih.nih.gov/grants/funding), through the Grants.gov web site (http://www.grants.gov/), or on the NIH Guide to Grants and Contracts (https://grants.nih.gov/funding/searchguide/index.html#/). For applications that require the PHS 398, the most recent version of the form and instructions are available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. Electronic applications are submitted through the Grants.gov website. Completed PHS 398 applications should be submitted to the National Institutes of Health, Center for Scientific Review, 6701 Rockledge Drive, Room 1040 - MSC 7710, Bethesda, MD 20892-7710 or Bethesda, MD 20817 (for express/courier service). For assistance contact GrantsInfo, Telephone: (301) 435-0714, Email: GrantsInfo@nih.gov. National Research Services Awards: Completed application forms should be submitted to the Office of Research Manpower, Center for Scientific Review, Grants, National Institutes of Health, Bethesda, MD 20892. This program is subject to the provisions of 45 CFR, Part 92 for State and local governments and OMB Circular No. A-110 for nonprofit organizations.

Award procedure

The major elements in evaluating proposals include assessments of: (1) the scientific merit innovation and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; (6) the relevance and importance to the announced program objectives and when applicable,and (7) the adequacy of assurances detailing the proposed means for safeguarding human or animal subjects.

Time to approval or disapproval

> 180 Days. Overall from 180 to 300 days. Research Grants and Cooperative Agreements: approximately 6-10 months

Renewals

Research grants: renewals by competitive application and review. Extension by request and administrative action

Appeals

An applicant institution (including the Authorized Organization Representative and the Program Director/Principal Investigator (PD/PI)) may question the substantive or procedural aspects of the review of their application by submitting an appeal. An appeal is a written communication from the applicant that meets the following three criteria: 1) is received after issuance of the summary statement and up to 30 calendar days after the second level of peer review, 2) describes a flaw or perceived flaw in the review process for a particular application, 3) is based on one or more of four allowable issues (described below). The four allowable issues are: (1) evidence of bias on the part of one or more peer reviewers; (2) conflict of interest, as specified in regulation at 42 CFR 52h.5."Scientific Peer Review of Research Grant Applications and Research and Development Contract Projects", on the part of one or more peer reviewers; (3) lack of appropriate expertise within the scientific review group (which performed the peer review); and (4) factual error(s) made by one or more reviewers that could have substantially altered the outcome of review. A description of the NIH Peer Review Policy and Procedures is available at http://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-064.html.

Grant opportunities

Quick answers

What is Assistance Listing 93.473?

Assistance Listing 93.473 is Complementary and Integrative Health - Research Projects, a federal grant program run by National Institutes of Health (Department of Health and Human Services).

What is the CFDA number for Complementary and Integrative Health - Research Projects?

Its CFDA number is 93.473: Assistance Listing numbers were called CFDA numbers before 2018.

Are there open grant opportunities under 93.473?

4 listed opportunities under 93.473 are open or forecasted. The latest, NIH Pragmatic Trials Conducted in Health Care Systems, was posted on April 29, 2026.

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