A Holistic Approach to Study Non-Addictive Natural Products for Pain Management
Forecasted Federal grant Posted
- Opportunity number
- PAR-28-009
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Public or Indian Housing Auth.
- For Profit Organizations
- Small Businesses
- Independent School Districts
- State Governments
- Higher Education Inst. (Public)
- Higher Education Inst. (Private)
- Tribal Organizations (Not Federally Recognized)
- 501(c)(3) Nonprofits
- Special District Governments
- County Governments
- Non-501(c)(3) Nonprofits
- City/Township Governments
- Tribal Governments (Federally Recognized)
- Other
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health National Center for Complementary and Integrative Health is forecasting a Notice of Funding Opportunity to support collaborative interdisciplinary research on non-addictive natural products for chronic pain management; a NOFO publication date is not specified.
Eligible applicants include public or Indian housing authorities, for-profit organizations, small businesses, independent school districts, state governments, higher education institutions (public and private), tribal organizations (federally and non-federally recognized), 501(c)(3) and non-501(c)(3) nonprofits, special district governments, county and city/township governments, Indian/Native American tribal governments, eligible federal agencies, U.S. territories or possessions, faith-based or community-based organizations, regional organizations, and non-domestic entities.
The research must take a holistic, systems-oriented approach examining how natural products influence chronic pain through coordinated biological pathways across multiple organ systems—including digestive, immune, vascular, musculoskeletal, lymphatic, metabolic/adipose tissue, and nervous systems. In-scope products include botanicals, dietary supplements, and other naturally derived compounds commonly used by the public as well as those with emerging usage or therapeutic potential. Investigators are encouraged to explore dose optimization based on hormesis principles and optimal intervention timing aligned with dynamic phases of pain and inflammation. The program emphasizes rigorous mechanistic studies generating foundational insights to inform future translational research.
This opportunity is assigned to CFDA 93.473 (Complementary and Integrative Health - Research Projects). Applications will undergo two-stage peer review assessing scientific merit, experimental design adequacy, investigator competency, facility and resource adequacy, budget justification, alignment with program objectives, and safeguards for human or animal subjects. Standard NIH timelines project six to ten months from application submission through grant disbursement.
Forecast synopsis
The National Center for Complementary and Integrative Health (NCCIH) intends to publish a Notice of Funding Opportunity (NOFO) to support collaborative interdisciplinary research that advances foundational understanding of non-addictive natural products for chronic pain management through a holistic, system-oriented approach. This initiative aligns with the NIH Helping to End Addiction Long-term (HEAL) Initiative by promoting safe, non-addictive, and prevention-oriented strategies for pain relief.
Chronic pain affects tens of millions of adults in the United States, contributing to disability, diminished quality of life, and significant healthcare costs. Despite widespread public use of natural products, such as botanicals, dietary supplements, and other naturally derived compounds for pain relief, scientific evidence has not kept pace with demand. Existing research often focuses on single molecular targets or isolated pathways, which fail to capture the complex, multisystem actions of these products.
The scope of natural products under this NOFO includes those commonly used by the public as well as those with emerging usage or therapeutic potential. Research is expected to take a holistic approach that examines how these products influence pain through coordinated biological pathways across the multiple organ systems, such as digestive, immune, vascular, musculoskeletal, lymphatic, metabolic/adipose tissues, and nervous system. Studies should also explore dose optimization based on the principle of hormesis, where low doses may elicit beneficial or adaptive effects while higher doses could be ineffective or harmful. In addition, investigators are encouraged to identify optimal intervention timing that aligns with the dynamic phases of pain and inflammation, thereby maximizing therapeutic outcomes and supporting physiological recovery.
This program emphasizes rigorous mechanistic studies that generate foundational insights to inform future translational research and guide the development of safe, evidence-based, non-addictive strategies for pain management.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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