Dietary Supplement Research Program

Active

Assistance listing
93.321
Agency
Grant awards
Not on record

Program facts

Treasury account
  • 75-4084-6-0-000
More information

Program details come from SAM.gov Assistance Listings. Updated .

About this program

The National Institutes of Health Office of Dietary Supplements (CFDA 93.321) funds research and knowledge translation activities related to dietary supplements and natural products, with multiple grant opportunities currently open as of March 2024 and earlier opportunities closed through September 2023.

The program funds pre-clinical, clinical, behavioral, and epidemiological research on dietary supplements and natural products, including characterization of botanical ingredients, validation of analytical methods for supplement constituents, translational research advancing natural products toward clinical trials, and computational approaches to analyze chemical and biological data from natural products. The Office of Dietary Supplements also supports research building capacity for future dietary supplement research and training programs strengthening the field's workforce.

The program's active opportunities reflect a portfolio mix dominated by Project Grants with a smaller share of Cooperative Agreements. Recent solicitations posted in March 2024 include three major components of the Consortium Advancing Research on Botanicals and Other Natural Products (CARBON) Program: RFA-AT-24-007 (Limited Competition for a nuclear magnetic resonance research resource for natural product data, due July 8, 2024); RFA-OD-24-014 (Botanical Dietary Supplements Translational Research Teams using multi-PD/PI collaborative teams to advance botanical products toward clinical trials, due July 8, 2024); and RFA-AT-24-008 (computational tools to aggregate and analyze natural product data using artificial intelligence and machine learning, due June 28, 2024). Earlier administrative supplement opportunities (PA-20-227 and PA-20-252) supported dietary supplement research and validation studies of analytical methods, though those closed in April 2023 and April 2022, respectively.

Award eligibility is broad: domestic public and private nonprofits, for-profit organizations, institutions of higher education, hospitals, laboratories, state and local governments, and federally recognized tribal entities all qualify. Some initiatives accept applications from foreign organizations. Awards are made for at least one year and are subject to three-year record retention requirements. Administrative supplements are non-renewable; other programs may be renewable depending on the specific funding opportunity announcement. Grantees must comply with competitive peer review for scientific merit and program relevance, except administrative supplements, which are reviewed by NIH scientific staff.

Objective and description

Objective

The NIH Office of Dietary Supplements will identify projects that should be conducted or supported by national research institutes; identify multi-disciplinary research related to dietary supplements that should be conducted or supported; and promote

Eligibility

Applicant eligibility

Awards can be made to domestic, public or private, non-profit or profit organization, institution of higher learning, university, hospital, laboratory, or other institution including state and local units of government and tribal entities. Some initiatives will accept applications from foreign organizations. Additional details on eligibility will be specified in the funding opportunity announcement

Beneficiary eligibility

Institutions as described above.

Credentials and documentation

Applications must be submitted in compliance with instructions provided with each initiative.

Uses of assistance

To support research and other projects that strengthen knowledge and understanding of dietary supplements and translation of that knowledge into effective prevention strategies.

Length and time phasing of assistance

Almost all awards are made for at least one year. Applicants should refer to the specific funding opportunity announcement for further detail.

How to apply

Award procedure

Competitive peer reviewed applications are reviewed for scientific and technical merit by a scientific review group; and for program relevance by a national advisory council/board. Administrative supplements are reviewed for merit and relevance by NIH scientific staff.

Renewals

Administrative supplements are not renewable. Other programs may be renewable and applicants must review the funding opportunity announcement for further guidance

Appeals

A principal investigator may question the substantive or procedural aspects of his/her application by communication with the NIH scientific/research contact as provided in the initiative.

Grant opportunities

Opportunity Status Posted Applications due
Limited Competition: Research Resource for Natural Product Nuclear Magnetic Resonance Data (R24 Clinical Trial Not Allowed) RFA-AT-24-007 Closed
Botanical Dietary Supplements Translational Research Teams (RM1 Clinical Trial Required) RFA-OD-24-014 Closed
Leveraging Data at Scale to Understand Natural Product Impacts on Whole Person Health (R01 Clinical Trial Not Allowed) RFA-AT-24-008 Closed
Validation Studies of Analytical Methods for Dietary Supplement Constituents (Admin Supp - Clinical Trial Not Allowed) PA-20-252 Closed
Administrative Supplement for Research on Dietary Supplements (Admin Supp-Clinical Trial Not Allowed) PA-20-227 Closed
Pilot Projects Increasing the Impact of the NIH Centers for Advancing Research on Botanicals and Other Natural Products (PI2 CARBON) (R03 Clinical Trials Not Allowed) PAR-20-228 Closed
NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) PAR-20-217 Closed
NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required) PAR-20-218 Closed
Center for Natural Product Technology, Methodology, and Productivity Optimization (NP-TEMPO) (U41 Clinical Trial Not Allowed) RFA-AT-19-003 Closed
Botanical Dietary Supplements Research Centers (U19 Clinical Trial Optional) RFA-OD-19-001 Closed
Natural Products NMR Open Data Exchange (NP-NODE) (U24 Clinical Trial Not Allowed) RFA-AT-19-002 Closed
Global Noncommunicable Diseases and Injury Across the Lifespan: Exploratory Research (R21 Clinical Trials Optional) PAR-19-059 Closed
Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional) PAR-18-951 Closed
Pre-application: Opportunities for Collaborative Research at the NIH Clinical Center (X02 Clinical Trial Optional) PAR-18-950 Closed
Advancing Translational and Clinical Probiotic/Prebiotic and Human Microbiome Research (R01 Clinical Trial Optional) PA-18-902 Closed
Advancing Mechanistic Probiotic/Prebiotic and Human Microbiome Research (R01 Clinical Trial Not Allowed) PA-18-876 Closed
Administrative Supplements for Validation Studies of Analytical Methods for Dietary Supplement Constituents (Admin Supp - Clinical Trial Not Allowed) PA-18-818 Closed
Administrative Supplements for Research on Dietary Supplements (Admin. Supp.- Clinical Trial Not Allowed) PA-18-817 Closed
Food Specific Molecular Profiles and Biomarkers of Food and Nutrient Intake, and Dietary Exposure (R01 Clinical Trial Optional) PAR-18-727 Closed
Exploratory/Developmental Clinical Research Grants in Obesity (R21 Clinical Trial Optional) PA-18-720 Closed
Opportunities for Collaborative Research at the NIH Clinical Center (U01 - Clinical Trial Optional) PAR-18-646 Closed
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp - Clinical Trial Optional) PA-18-591 Closed
Exploratory/Developmental Clinical Research Grants in Obesity (R21 Clinical Trial Optional) PA-18-104 Closed
Diet and Physical Activity Assessment Methodology (R21 Clinical Trial Optional) PAR-18-112 Closed
Diet and Physical Activity Assessment Methodology (R01 Clinical Trial Optional) PA-18-010 Closed
Maternal Nutrition and Pre-pregnancy Obesity: Effects on Mothers, Infants and Children (R01 Clinical Trial Optional) PA-18-135 Closed
Nutrigenetics and Nutrigenomics Approaches for Nutrition Research (R01 Clinical Trial Optional) PA-18-034 Closed
Advancing Translational and Clinical Probiotic/Prebiotic and Human Microbiome Research (R01 Clinical Trial Optional) PA-18-001 Closed
Administrative supplements for validation studies of analytical methods for dietary supplements and natural products (Admin. Suppl.) PA-17-447 Closed
Global Brain and Nervous System Disorders Research Across the Lifespan (R21) PAR-17-313 Closed
Global Brain and Nervous System Disorders Research Across the Lifespan (R01) PAR-17-314 Closed
Administrative Supplements for Research on Dietary Supplements (Admin Supp) PA-17-307 Closed
Nutrigenetics and Nutrigenomics Approaches for Nutrition Research (R01) PA-16-332 Closed
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp) PA-16-287 Closed
Successor-in-Interest (Type 6 Parent) PA-16-286 Closed
Change of Grantee Organization (Type 7 Parent) PA-16-285 Closed
Diet and Physical Activity Assessment Methodology (R01) PA-16-167 Closed
Global Noncommunicable Diseases and Injury Across the Lifespan: Exploratory Research (R21) PAR-16-052 Closed
Administrative Supplements to NIH Awards for Validation Studies of Analytical Methods for Natural Products (Admin Supp) PA-16-048 Closed
Opportunities for Collaborative Research at the NIH Clinical Center (U01) PAR-15-287 Closed
Administrative Supplements for Research on Dietary Supplements (Admin Supp) PA-15-258 Closed
Diet and Physical Activity Assessment Methodology (R21) PAR-15-171 Closed
Diet and Physical Activity Assessment Methodology (R01) PAR-15-170 Closed
Exploratory/Developmental Clinical Research Grants in Obesity (R21) PA-15-163 Closed
Advancing Mechanistic Probiotic/Prebiotic and Human Microbiome Research (R01) PA-15-135 Closed
Advancing Translational and Clinical Probiotic/Prebiotic and Human Microbiome Research (R01) PA-15-127 Closed
Maternal Nutrition and Pre-pregnancy Obesity: Effects on Mothers, Infants and Children (R01) PA-15-100 Closed
Food Specific Molecular Profiles and Biomarkers of Food and Nutrient Intake, and Dietary Exposure (R01) PAR-15-024 Closed
Global Brain and Nervous System Disorders Research Across the Lifespan (R01) PAR-14-332 Closed
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Quick answers

What is Assistance Listing 93.321?

Assistance Listing 93.321 is Dietary Supplement Research Program, a federal grant program run by National Institutes of Health (Department of Health and Human Services).

What is the CFDA number for Dietary Supplement Research Program?

Its CFDA number is 93.321: Assistance Listing numbers were called CFDA numbers before 2018.

Are there open grant opportunities under 93.321?

No opportunity listed under 93.321 is open now. The latest, Limited Competition: Research Resource for Natural Product Nuclear Magnetic Resonance Data (R24 Clinical Trial Not Allowed), was posted on March 14, 2024.

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