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All Federal Grant Programs
Biotechnology Risk Assessment Research
Posted
9/3/18
Assistance Listing Number
10.219
Overview
Grant Opportunities
Grant Awards
321
Federal Agency
National Institute of Food and Agriculture
Applicant Types
Not listed
Beneficiary Types
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Additional Information
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Name
Description
Awardee
Assistance Type
Dollars Obligated
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Award Date
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Updated At
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20193352230064
THIS RESEARCH ALIGNS WITH AREA 5E OF THE BRAG RFA, MODELING APPROACHES TO UNDERSTAND THE IMPACT OF GENETIC ENGINEERING FOR POPULATION SUPPRESSION OR ALTERATION (GENE DRIVE, RELEASE OF INSECT CARRY DOMINANT LETHAL, ETC.) ON TARGET POPULATIONS OR NON-TARGET SPECIES THAT INTERACT WITH THE TARGETED SPECIES, ESPECIALLY WHEN INCORPORATING BIOLOGICALLY REALISTIC PARAMETERS (E.G. OF RESISTANCE EVOLUTION, NUMBERS OF INDIVIDUALS RELEASED, ETC.)OUR GOALS ARE (1) TO ASSESS THE RISKS OF GENOME EDITING TECHNOLOGIES, SUCH AS CRISPR-CAS9, WHEN USED TO MAKE GENE DRIVES TO SUPPRESS POPULATIONS OF CROP PESTS; (2) TO ASSESS THE EFFECT OF GENETIC BACKGROUND ON THE SPREAD OF GENE DRIVES; AND, TO IDENTIFY AND CHARACTERIZE DRIVE RESISTANT MUTATIONS PRE-EXISTING IN WILD POPULATIONS OR CREATED BY FEATURES OF CRISPR/CAS 9 ITSELF ; AND, (3) TO INCORPORATE OUR EXPERIMENTAL FINDINGS INTO MODELS OF GENE DRIVE.WE PROPOSE TO CONSTRUCT GENE DRIVES AND INTRODUCE THEM INTO POPULATIONS OF THE FLOUR BEETLE TRIBOLIUM CASTANEUM, A STORAGE GRAIN PEST. WE WILL IDENTIFY KEY FACTORS GOVERNING THE SPREAD OF GENE DRIVES IN WILD POPULATIONS AND IN GENETICALLY SUBDIVIDED POPULATIONS COMPARABLE TO REGIONAL AGRICULTURAL FIELDS. WE WILL DEVELOP GENE DRIVES ON GENETIC BACKGROUNDS SIMILAR TO AND DIVERGENT FROM THE LABORATORY STRAINS AND CHARACTERIZE THE GENETIC FEATURES OF POPULATIONS THAT REDUCE DRIVE EFFICIENCY. OUR RESULTS AND METHODS WILL INFORM THE DEVELOPMENT OF GUIDELINES FOR REGULATORY AGENCIES CHARGED WITH EVALUATING THE LIKELIHOOD OF SUCCESS OF PROPOSED DRIVE RELEASES.WE PROPOSE TO ASSESS THE BIOLOGICAL RISKS ASSOCIATED WITH THE PROPOSED USE OF GENE DRIVES BASED ON CRISPR-CAS9 GENOME EDITING TECHNOLOGY TO CONTROL CROP PESTS. MOREOVER, WE PROPOSE TO CONSTRUCT AND EVALUATE THE EFFICACY OF DRIVE REVERSAL SAFEGUARDS FOR CONTROLLING OR STOPPING THE SPREAD OF ARTIFICIAL GENE DRIVES AND PREVENTING FUTURE SPREAD OF A DRIVE TARGETING THE SAME REGION WITHIN A GENE OF INTEREST.
Trustees Of Indiana University
Project Grant
$350.3k
9/1/19
11/5/24
201333522210971
SILENCING OF NATURALLY OCCURRING GENES CONTROLLING SEED DORMANCY TO REDUCE FITNESS OF TRANSGENE-CONTAMINATED WEEDY RICE
South Dakota State University
Project Grant
$495.7k
9/1/13
8/15/13
201033522217151
RECOMBINASE-MEDIATED TARGETED GENE INTEGRATION AND EXCISION FOR MARKER-FREE TRANSGENIC CROPS
Division Of Agriculture Of The University Of Arkansas
Project Grant
$365.2k
9/1/10
8/31/10
102192003Q46416
RISK ANALYSIS AND ENHANCEMENT OF TRANSGENE STABILITY IN INSECTS FOR BIOLOGICAL CONTROL
None
Project Grant
$295.0k
9/1/03
8/19/03
201533522240991
NUTRITIONALLY-MEDIATED VARIATION IN HELICOVERPA ZEA SUSCEPTIBILITY TO BT TRANSGENIC CROPS
Texas A&M Agrilife Research
Project Grant
$499.0k
9/1/15
9/4/15