Viral INfections in the Young Lung- The VINYL Clinical Consortium (UG3/UH3 Clinical Trial Optional)
Closed Posted
- Opportunity number
- RFA-HL-26-006
- Agency
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National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
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- 93.838 Lung Diseases Research
- Funding instrument
- Cooperative Agreement
- Category
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- Health
- Eligible applicants
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- State Governments
- Public or Indian Housing Auth.
- City/Township Governments
- Independent School Districts
- Other
- Higher Education Inst. (Public)
- Non-501(c)(3) Nonprofits
- Tribal Organizations (Not Federally Recognized)
- Small Businesses
- Special District Governments
- Higher Education Inst. (Private)
- For Profit Organizations
- County Governments
- Tribal Governments (Federally Recognized)
- 501(c)(3) Nonprofits
- Points of contact
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- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Heart, Lung and Blood Institute (NHLBI), a division of the Department of Health and Human Services National Institutes of Health, is seeking to establish the Viral INfections in the Young Lung (VINYL) Clinical Consortium. The primary objective is to conduct a comprehensive clinical research study involving deep phenotyping of 1,500 children aged 0-2 years hospitalized with viral lower respiratory tract infections (LRTI), including bronchiolitis, pneumonia, and pediatric acute respiratory distress syndrome. The research aims to address critical knowledge gaps in understanding viral infections in young lungs, with a focus on identifying prognostic biomarkers, refining diagnosis and management, and longitudinally tracking pulmonary outcomes through pre-school age. Key evaluation criteria will likely include scientific merit, experimental design, investigator competency, research facilities, budget appropriateness, and potential for advancing medical understanding. The grant opportunity is currently in a forecast stage, with a projected application due date of November 10, 2025, allowing potential applicants time to develop collaborative research proposals.
The grant will utilize UG3/UH3 activity codes to fund one Clinical Coordinating Center (CCC) and Biorepository along with four Clinical Centers (CCs), operating under the Lung Diseases Research Federal Grant Program (CFDA 93.838). While specific award amounts are not detailed, similar NIH research consortia have historically ranged from hundreds of thousands to several million dollars. The longitudinal study will involve comprehensive data collection, including clinical assessments, electronic health record tracking, participant questionnaires, and follow-up evaluations of respiratory status, neurocognitive development, and sleep patterns when participants reach 4-5 years of age. Research will be conducted across selected clinical sites, with a primary focus on understanding the long-term respiratory health implications of early viral infections in infants and toddlers.
Synopsis
The objective of this program is to create a consortium of clinical sites that will perform deep phenotyping in 1500 babies, infants, and toddlers (0-2 years of age) with viral lower respiratory tract infections (LRTI) and hospitalized with acute bronchiolitis, pneumonia and/or pediatric acute respiratory distress syndrome (PARDS), and longitudinal follow up of participants for evidence of lung disease including asthma at age 4-5 years. Bronchiolitis, a condition unique to the young lung, is the leading cause of hospitalization for viral LRTI in 02-year-old children, including those born preterm. There are critical knowledge gaps in defining the condition, predicting its severity, and understanding the reasons for hospitalization, including the immature host respiratory immune response to viral infection, heterogeneity in response to different viruses, current interventions, significant practice variation in diagnosis and management and subsequent impact on lung health. To meet the need for deep phenotyping, identify appropriate subgroups, refine the diagnosis and management of these vulnerable patients during their hospitalization, and identify prognostic biomarkers for future airway and parenchymal disease, we propose the VINYL (Viral INfections in the Young Lung) clinical consortium, a pragmatic observational study, to perform deep phenotypic characterization of 1500 babies, infants and toddlers admitted to the pediatric floor and pediatric intensive care unit with viral LRTI. A longitudinal follow-up of participants after discharge using electronic health records and questionnaires and assessment of respiratory status at age 4-5 years will elucidate pulmonary outcomes from early viral LRTI, specifically asthma. Neurocognitive and general development, and sleep will also be assessed during follow up.
Files
| File | Type | Posted |
|---|---|---|
| RFA-HL-26-006-Full-Announcement.html | HTML file |
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