Viral INfections in the Young Lung- The VINYL Clinical Consortium- Data Analytics and Coordinating Center (DACC)(U24 Clinical Trial Optional)

Closed Posted

Opportunity number
RFA-HL-26-008
Agency
Applications due
Award size
Not on record

Opportunity facts

Assistance listings
Funding instrument
Cooperative Agreement
Category
  • Health
Eligible applicants
  • State Governments
  • Tribal Governments (Federally Recognized)
  • Public or Indian Housing Auth.
  • Non-501(c)(3) Nonprofits
  • City/Township Governments
  • Tribal Organizations (Not Federally Recognized)
  • Special District Governments
  • For Profit Organizations
  • Higher Education Inst. (Private)
  • Higher Education Inst. (Public)
  • Other
  • County Governments
  • Independent School Districts
  • Small Businesses
  • 501(c)(3) Nonprofits
Points of contact
Full announcement

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Heart, Lung and Blood Institute (NHLBI), part of the National Institutes of Health, is seeking to establish the Viral INfections in the Young Lung (VINYL) Clinical Consortium through a cooperative agreement. The primary objective is to create a research network that will perform deep phenotyping on 1,500 children aged 0-2 years with severe viral lower respiratory tract infections (LRTI), focusing on hospitalized cases of bronchiolitis, pneumonia, and pediatric acute respiratory distress syndrome (PARDS). The consortium will track these children longitudinally to assess lung disease development, particularly asthma, at ages 4-5. Eligible applicants include state and tribal governments, non-profits, higher education institutions, small businesses, and other public and private organizations. The evaluation criteria will likely assess scientific merit, technical approach, investigator qualifications, research innovation, and potential for advancing understanding of pediatric respiratory infections.

While specific award amounts are not detailed, the grant will be funded under the Lung Diseases Research Federal Grant Program (CFDA 93.838) and will consist of multiple components: a Data and Analytics Coordinating Center (DACC), a Clinical Coordinating Center (CCC) with a Biorepository, and four Clinical Centers. The research will be conducted across multiple sites, with a focus on addressing critical knowledge gaps in understanding viral respiratory infections in young children. The current notice is a forecast, with the actual application period not yet open, allowing potential applicants time to develop collaborations. The anticipated timeline includes initial research from 0-2 years of age, with follow-up assessments conducted when participants reach 4-5 years old.

Synopsis

The objective of this program is to create a consortium of clinical sites that will perform deep phenotyping in 1500 babies, infants, and toddlers (0-2 years of age) with viral lower respiratory tract infections (LRTI) and hospitalized with acute bronchiolitis, pneumonia and/or the pediatric acute respiratory distress syndrome (PARDS), and longitudinal follow up of participants for evidence of lung disease including asthma at age 4-5 years. Bronchiolitis, a condition unique to the young lung, is the leading cause of hospitalization for viral LRTI in 02-year-old children, including those born preterm. There are critical knowledge gaps in defining the condition, predicting its severity, and understanding the reasons for hospitalization, including the immature host respiratory immune response to viral infection, heterogeneity in response to different viruses, current interventions, significant practice variation in diagnosis and management and subsequent impact on lung health.

Files

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