Translational Bioinformatics and Experimental Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed)
Open Posted
- Opportunity number
- PAR-25-374
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $1,000,000
Opportunity facts
- Assistance listings
-
- 93.866 Aging Research
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Higher Education Inst. (Public)
- Non-501(c)(3) Nonprofits
- Higher Education Inst. (Private)
- State Governments
- Other
- Independent School Districts
- For Profit Organizations
- County Governments
- Public or Indian Housing Auth.
- Small Businesses
- Special District Governments
- Tribal Governments (Federally Recognized)
- 501(c)(3) Nonprofits
- Tribal Organizations (Not Federally Recognized)
- City/Township Governments
- Points of contact
-
- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health is soliciting applications for translational bioinformatics and experimental research using mouse models to test drug repurposing and combination therapies for Alzheimer's Disease and Related Dementias, with applications due May 7, 2028. Clinical trials are not allowed under this R01 mechanism.
Eligible applicants span a broad range: higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, state and local governments, tribal governments and organizations, small businesses, for-profit organizations, Indian housing authorities, and special district governments. Additional eligible applicants include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, HBCUs, AANAPISIs, TCCUs, faith-based and community-based organizations, federal agencies, regional organizations, non-domestic entities, and U.S. territories.
The initiative targets rigorous preclinical testing of drugs or drug combinations currently used for other conditions, investigational drugs at various stages of development, and repurposable or investigational candidates combined with non-pharmacologic interventions. The central goal is establishing robust proof of concept enabling rational drug repurposing and combination therapy development for AD/ADRD treatment and prevention.
The funding opportunity falls under Assistance Listing 93.866 (Aging Research) administered by the National Institute on Aging. Award amounts, the number of awards expected, period of performance, cost share requirements, and specific evaluation criteria are not detailed in the source materials provided. Applicants should consult the full NOFO (PAR-25-374) and application instructions (PKG00289839.pdf) for complete programmatic requirements and submission procedures.
Synopsis
This Notice of Funding Opportunity (NOFO) invites applications that propose to use mouse models to conduct rigorous preclinical testing of drugs or drug combinations currently used for other conditions, as well as investigational drugs at various stages of clinical development, predicted to be efficacious in AD/ADRD. This initiative will also support preclinical testing of repurposable or investigational drug candidates in combination with non-pharmacologic interventions leading to robust translational outcomes. The central goal is to establish robust proof of concept that will enable rational drug repurposing and combination therapy development for the treatment and prevention of AD/ADRD.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-374-Full-Announcement.html | HTML file | |
| PKG00289839.pdf |
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