PAR-25-374-Full-Announcement.html

This Notice of Funding Opportunity (NOFO) from the Department of Health and Human Services' National Institutes of Health (NIH) seeks applications for research using mouse models to test drugs and drug combinations for Alzheimer's Disease and Related Dementias (AD/ADRD). The funding opportunity, designated as PAR-25-374, falls under the Aging Research grant program (CFDA 93.866) and is structured as an R01 grant that does not allow clinical trials.

The initiative focuses on repurposing existing drugs currently used for other conditions, as well as testing investigational drugs in preclinical development. Eligible applicants include a wide range of organizations, from small businesses and nonprofits to higher education institutions and tribal organizations. The research must establish proof of concept for drug repurposing and combination therapy development, including testing drug candidates in combination with non-pharmacologic interventions. The NOFO specifically emphasizes translational bioinformatics and experimental approaches to advance treatment and prevention strategies for AD/ADRD.